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Together, our results suggest that KLF4 regulates asthma development in a TSLP- and fibrocyte-dependent manner.
Pronounced correlations between KLK10/KLK11 (rs = 0.647) and between KLK9/KLK15 (rs = 0.716) mRNA, but not between other combinations, indicate coordinate expression of distinct pairs of peptidases
Variations in KLK15, but not KLK11 expression were significantly associated with prognosis in gastric cancer
KLK11 mRNA expression could be considered as a new molecular prognostic biomarker in colorectal adenocarcinoma
hK11 expression in gastric cancer appears to be associated with a better prognosis. hK11 may be a prognostic biomarker of gastric cancer.
The aim of this study was to monitor serum levels of two microRNAs (miR-21 and miR-141) and three kallikreins (hK3/PSA, hK11, and hK13) before and 1, 5, and 30 days after radical prostatectomy.
Our data showed that UVB-induced TSLP might increase secretion of the T-helper type 2-attracting chemokine (c-c motif) ligand 17 by human dendritic cells.
HOXB8 and KLK11 may be classified as valuable biomarkers, as they can predict the effects of FOLFOX4 chemotherapy in primary advanced colorectal cancer patients
Human airway trypsin-like protease can stimulate mucin5AC hypersecretion through a PAR2-mediated signaling pathway in 16HBE cells.
Patients harboring KLK11-positive tumors had a significantly decreased risk of death.
Low KLK11 protein expression is associated with gastric cancer.
For the first time, we report lower expression of KLK11 in CaP compared to BPH and slight upregulation of KLK11 in advanced tumors compared to localized ones
the up-regulation of TMPRSS2 and the down-regulation of KLK11 in advanced and more aggressive tumors may open the feasibility of being used as biomarkers distinguishing the tumor aggressiveness as well as novel prognostic indicators for prostate cancer.
hK11 may be another prognostic biomarker of low rectal carcinoma. Strong positive hK11 staining associated with various clinicopathologic features. Patients with weak hK11 positive expression showed better survival rates.
Data show that it was unable to distinguish men with and without prostate cancer using multiple kallikreins as urinary biomarkers.
may be useful marker for distinguishing prostate cancer and benign prostatic hypertrophy
Human kallikrein 11: a new biomarker of prostate and ovarian carcinoma.
Hippostasin isoform 3 may play a role in the prostate, including reproductive and/or tumorigenic functions.
There is a significant association between lower expression of prostate-type KLK11 and higher tumor stage, Gleason score, and tumor grade.
hK11 is a novel, independent marker of favorable prognosis in patients with ovarian cancer
KLK11 expression may play an important role in ovarian cancer development
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in multiple transcript variants encoding distinct isoforms which are differentially expressed.
kallikrein-related peptidase 11
, kallikrein 11
, protease, serine, 20
, serine protease 20
, trypsin-like protease