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anti-Human Kallikrein 8 Antibodies:
anti-Rat (Rattus) Kallikrein 8 Antibodies:
anti-Mouse (Murine) Kallikrein 8 Antibodies:
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Human Polyclonal Kallikrein 8 Primary Antibody for IF (p), IHC (p) - ABIN759116
Hadamitzky, Herring, Kirchhof, Bendix, Haight, Keyvani, Lückemann, Unteroberdörster, Schedlowski: Repeated Systemic Treatment with Rapamycin Affects Behavior and Amygdala Protein Expression in Rats. in The international journal of neuropsychopharmacology 2019
Study findings provide a comprehensive picture of the molecular mechanisms underlying the enzyme activity of recombinant human KLK8. Enzyme kinetics with optimized substrates showed stimulation by Ca2+ and inhibition by Zn2+, which are physiological regulators. Crystal structures of KLK8 with a ligand-free active site and with the inhibitor leupeptin explain the subsite specificity and display Ca2+ bound to the 75-loop.
KLK8 levels are higher in female brain and female sex hormone increases KLK8 in neuronal/glial cells. Hippocampal KLK8 protein levels were drastically increased in women patients.
Telbivudine treatment resulted in increased levels of serum KLK8 protein. Furthermore, eGFR increase was associated with body height-adjusted, post-treatment KLK8 levels
mRNA expression levels of KLK6 and KLK8 in advanced serous ovarian cancer
elevated KLK8 expression was correlated with the progression of colorectal cancer.
KLK8 mRNA expression is associated with aggressive tumor characteristics and it can serve as a novel independent biomarker of unfavorable prognosis for BC patients.
Occurring independently of cyclophilins and of furin that mediate human papillomavirus 16 L2 exposure, KLK8-mediated cleavage of L1 likely facilitated access to L2, located in the capsid lumen, and potentially uncoating.
It dissects a schizophrenic susceptibility gene, NRG1.
KLK8 and KLK14 can signal differentially via the PARs to affect tissue function
KLK8 as a new active serine protease in human stratum corneum and sweat
The results of this study indicate that most salivary gland tumors show high levels of expression of KLK8.
The KLK8-T4 alternative splice variant, alone or in combination, may be a new independent marker of unfavorable prognosis in lung cancer.
Cervical cancer expressed high level of TADG-14. May play important role in invasion and metastasis. Appears only in abundance in tumor tissue and contains secretion signal sequence. Possible diagnostic use or as therapeutic target.
Expression of hK8 is increased during the development of ovarian cancer and down-regulated during ovarian cancer progression.
Amino-terminal sequencing of the activated enzyme demonstrated the cleavage of a 9-aa propeptide from the pro-enzyme; substrate specificiy and effect of metal ions and pH is demonstrated
KLK8 expression confers a favorable clinical outcome in non-small cell lung cancer by suppressing tumor cell invasiveness.
analysis of how a mutation leads to the origin of a novel splice form of neuropsin (KLK8), a gene involved in learning and memory
kallikreins 5, 7, 8, and 10 are abundantly expressed in human OSCC and may be implicated in malignant progression
The processed end-point enzymes are the same for both type I and type II kallikrein 8, suggesting that the emergence of type II kallikrein 8 in the human brain likely leads to functional modifications of kallikrein 8.
Combination of KLK2, 3, 13, and 14 and KLK1, 2, 5, 6, 7, 8, 10, 13, and 14 showed very strong discriminatory potential for semen liquefaction and viscosity, respectively.
Letter: NGF-p75 and neuropsin/KLK8 pathways may cooperate in regulation of epidermal homeostasis in inflamed skin.
Klk8 is involved in the proliferation and migration of keratinocytes through Klk6 in the early stages of wound healing, and possibly in keratinocyte differentiation associated with the upregulation of PAR2 in the late stages of wound healing.
KLK8 is involved in synaptic tagging during LTP at basal and apical dendritic inputs.
the serine protease neuropsin is critical for stress-related plasticity in the amygdala by regulating the dynamics of the EphB2-NMDA-receptor interaction, the expression of Fkbp5 and anxiety-like behaviour
Klk8 might thus be involved in tissue development and rearrangement.
role of loop structures in the activity of serine protease and regulated secretion
Neuropsin was localized extracellularly in neuronal cell bodies and their neurites in mouse hippocampus. Neuropsin may be involved in neurite outgrowth during the development of the nervous system.
gene expression of a serine-protease neuropsin in the mouse vagina, and as a marker of the estrogen-independent persistent proliferation and cornification of the vaginal epithelium
Neuropsin is the first extracellular protease to show the evident induction of expression and activity by decidualization and might contribute to the remodeling of extracellular components after decidualization.
mouse MCs store at least two distinct families of tryptic-like proteases in their secretory granules, including PRSS19
Presynaptic adhesion molecule L1 is a substrate for neuropsin in the hippocampus.
study demonstrates changes in the expression of neuropsin and protease M/neurosin in oligodendrocytes following hemisection of the spinal cord
Neuropsin-/- mice showed attenuated demyelination and delayed oligodendroglial death early during the course of autoimmune encephalomyelitis
Nrpn is necessary for establishment of LTP and has a significant role in memory acquisition.
These observations suggest that neuropsin is involved in the secondary phase of the pathogenesis of SCI mediated by demyelination, oligodendrocyte death, and axonal degeneration.
Neuropsin-dependent late associativity is particularly important in nonstressful associative memory.
Increased anxiety-like behavior in neuropsin (kallikrein-related peptidase 8) gene-deficient mice.
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in four transcript variants encoding four different isoforms. The isoforms exhibit distinct patterns of expression that suggest roles in brain plasticity and ovarian cancer.
, serine protease 19
, serine protease TADG-14
, tumor-associated differentially expressed gene 14 protein
, brain serine protease 1
, kallikrein 8 (neuropsin/ovasin)
, kallikrein-related peptidase 8
, kallikrein 8
, Brain Serine protease 1
, protease, serine, 19 (neuropsin)