CrkL Products
(V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian)-Like (CRKL))
Categories
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009].
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Featured CrkL Categories
CrkL Antibodies
High quality antibodies with extensive validation data.
CrkL ELISA Kits
Reliable ELISA kits for a wide range of species.
CrkL Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended CrkL Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF, PLA
Validations
- (1)
- (7)
Cat. No.
ABIN514605
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, PLA, RNAi
Validations
- (2)
- (8)
Cat. No.
ABIN514606
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, FACS
Validations
- (1)
- (3)
Cat. No.
ABIN969064
Quantity
100 μL
Datasheet
Datasheet
Recommended CrkL ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6960414
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6960415
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380116
Quantity
2 x 96 tests
Datasheet
Datasheet
Recommended CrkL Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1350367
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1350369
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN667314
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our CrkL products
: "Increased Soluble CrkL in Serum of Breast Cancer Patients Is Associated with Advanced Disease." in: Cancers, Vol. 11, Issue 7, (2019) (PubMed).: "CRKL promotes lung cancer cell invasion through ERK-MMP9 pathway." in: Molecular carcinogenesis, Vol. 54 Suppl 1, pp. E35-44, (2015) (PubMed).
: "CRKL protein overexpression enhances cell proliferation and invasion in pancreatic cancer." in: Tumour biology, Vol. 36, Issue 2, pp. 1015-22, (2015) (PubMed).
: "Clinical significance and biological roles of CRKL in human bladder carcinoma." in: Tumour biology, Vol. 35, Issue 5, pp. 4101-6, (2014) (PubMed).
: "Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma." in: Molecular & cellular proteomics : MCP, Vol. 12, Issue 5, pp. 1335-49, (2013) (PubMed).
: "Escherichia coli virulence protein NleH1 interaction with the v-Crk sarcoma virus CT10 oncogene-like protein (CRKL) governs NleH1 inhibition of the ribosomal protein S3 (RPS3)/nuclear factor κB ..." in: The Journal of biological chemistry, Vol. 288, Issue 48, pp. 34567-74, (2013) (PubMed).
: "Genomic and functional analysis identifies CRKL as an oncogene amplified in lung cancer." in: Oncogene, Vol. 29, Issue 10, pp. 1421-30, (2010) (PubMed).
: "Structural and functional basis of a role for CRKL in a fibroblast growth factor 8-induced feed-forward loop." in: Molecular and cellular biology, Vol. 29, Issue 11, pp. 3076-87, (2009) (PubMed).
: "PI3K links NKG2D signaling to a CrkL pathway involved in natural killer cell adhesion, polarity, and granule secretion." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 11, pp. 6933-42, (2009) (PubMed).
: "Active (p)CrkL is overexpressed in human malignancies: potential role as a surrogate parameter for therapeutic tyrosine kinase inhibition." in: Oncology reports, Vol. 15, Issue 2, pp. 353-9, (2006) (PubMed).
Synonyms and alternative names related to CrkL
CRK like proto-oncogene, adaptor protein (CRKL), v-crk avian sarcoma virus CT10 oncogene homolog-like (crkl), v-crk avian sarcoma virus CT10 oncogene homolog-like (Crkl), 1110025F07Rik, AA589403, AI325100, CRKL, Crkol, wu:fa55g05, wu:fj60e01, zgc:63469Protein level used designations for CrkL
- v-crk sarcoma virus CT10 oncogene homolog (avian)-like
- crk-like protein
- v-crk sarcoma virus CT10 oncogene homolog-like
- v-crk avian sarcoma virus CT10 oncogene homolog-like
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