Browse our SSH1 Proteins (SSH1)

The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

• slingshot homolog 1 (Drosophila) (Ssh1)
• slingshot protein phosphatase 1 (SSH1)

• AW551225 protein
• Gm1394 protein
• Gm1395 protein
• mSSH-1L protein
• SSH-1 protein
• Show all synonym aliases
• SSH1L protein

SSH-1L , SSH-like protein 1 , protein phosphatase Slingshot homolog 1 , slingshot 1L , slingshot-like 1 , hSSH-1L , slingshot homolog 1