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Human Polyclonal Arl6ip5 Primary Antibody for ELISA, WB - ABIN249658
Lin, Orlov, Ruggiero, Dykes-Hoberg, Lee, Jackson, Rothstein: Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18. in Nature 2001
Show all 2 Pubmed References
Human Polyclonal Arl6ip5 Primary Antibody for ELISA, IHC - ABIN184829
Wang, Gong, Chen, Liu, Li, Li, Zhou: JWA regulates XRCC1 and functions as a novel base excision repair protein in oxidative-stress-induced DNA single-strand breaks. in Nucleic acids research 2009
Show all 2 Pubmed References
Glutamate transporter (show SLC1A1 Antibodies)-associated protein 3 (show HSPB3 Antibodies)-18 (GTRAP3-18), an anchor protein (show CELSR3 Antibodies) that retains interacting proteins in the endoplasmic reticulum, is a critical regulator of food intake and body weight by interacting with POMC (show POMC Antibodies). GTRAP3-18-deficient mice showed hypophagia, lean bodies, and lower blood glucose, insulin (show INS Antibodies), and leptin (show LEP Antibodies) levels with increased serum and brain alpha-MSH levels, leading to AMPK (show PRKAA1 Antibodies) inhibition.
Protective effect of JWA against paraquat neurotoxicity involves regulation of the MEK (show MDK Antibodies)/PI3K-Nrf2 (show NFE2L2 Antibodies) axis.
the JWA deficiency through cascading FAK (show PTK2 Antibodies)-PI3K-Akt (show AKT1 Antibodies)-mTOR (show FRAP1 Antibodies) pathway increases the newborn neurons.
These findings indicated that Arl6ip5 was an anti-catabolic factor by binding with RANKL (show TNFSF11 Antibodies) and disturbing its subcellular trafficking in osteoblast.
Arl6ip5 is a novel regulator of bone formation in osteoblasts.
This study provided evidence that astrocytic JWA expression protects DA neurons from degeneration and plays an important role in neuroprotection via inhibition of ROS (show ROS1 Antibodies) and NF-kappaB (show NFKB1 Antibodies) activation.
The double-fluorescent immunohistochemical analysis revealed that addicsin and TR1 (show TXNRD1 Antibodies) were coexpressed in neurons
Data show the importance of JWA (Arl6ip5) in skin homeostasis and in the process of skin tumor development.
This study demonistrated that GTRAP3-18(-/-) mice performed better in motor/spatial learning and memory tests. The suppression of GTRAP3-18 increases neuronal resistance to oxidative stress by increasing GSH content and also facilitates cognitive function
Arl6ip1 (show ARL6IP1 Antibodies) is a novel addicsin-associated partner that promotes EAAC1 (show SLC1A1 Antibodies)-mediated glutamate (show GRIN1 Antibodies) transport activity by decreasing the number of addicsin molecules available for interaction with EAAC1 (show SLC1A1 Antibodies).
These data demonstrated that JWA suppressed the migration/invasion of breast carcinoma cells by downregulating the expression of CXCR4 (show CXCR4 Antibodies), and suggested that JWA may harbor prognostic and therapeutic potential in patients with breast cancer.
increased RNF185 (show RNF185 Antibodies) expression facilitated GC cell migration in vitro and promoted GC metastasis in vivo by downregulating JWA expression.
our results demonstrate that JWA is a novel negative regulator of HER2 (show ERBB2 Antibodies) expression...in HER2 (show ERBB2 Antibodies)-positive gastric cancer cells
Protective effect of JWA against paraquat neurotoxicity involves regulation of the MEK (show MAP2K1 Antibodies)/PI3K (show PIK3CA Antibodies)-Nrf2 (show GABPA Antibodies) axis.
JWA and topoisomerase II (show TOP2 Antibodies) alpha regulate each other in tumor cells arrested in G2/M.
the JWA gene may regulate human breast cancer cells through the MAPK (show MAPK1 Antibodies) signaling pathway using different types of regulation.
This review gives an overview of EAAC1 (show SLC1A1 Antibodies)-mediated GSH synthesis, and its regulatory mechanisms by GTRAP3-18 in the brain, and a potential approach against neurodegeneration.
JWA reverses cisplatin resistance via the CK2 (show CSNK2A1 Antibodies)-XRCC1 (show XRCC1 Antibodies) pathway in human gastric cancer cells.
data demonstrate that JWA plays a crucial role in HCC (show FAM126A Antibodies) progression and suggest JWA may be a potential prognostic biomarker and therapeutic target for HCC (show FAM126A Antibodies).
A significant negative correlation between JWA and ILK (show ILK Antibodies) in melanoma biopsies.
Expression of this gene is affected by vitamin A. The encoded protein of this gene may be associated with the cytoskeleton. A similar protein in rats may play a role in the regulation of cell differentiation. The rat protein binds and inhibits the cell membrane glutamate transporter EAAC1. The expression of the rat gene is upregulated by retinoic acid, which results in a specific reduction in EAAC1-mediated glutamate transport.
ADP-ribosylation-like factor 6 interacting protein 5
, ADP-ribosylation factor-like 6 interacting protein 5
, ADP-ribosylation factor-like protein 6-interacting protein 5
, ARL-6-interacting protein 5
, PRA1 family protein 3
, glutamate transporter EAAC1-interacting protein
, prenylated Rab acceptor protein 2
, protein JWa
, PRA1 domain family 3
, cytoskeleton related vitamin A responsive protein
, cytoskeleton-related vitamin A-responsive protein
, dermal papilla derived protein 11
, dermal papilla-derived protein 11
, glutamate transporter EEAC1-associated protein
, putative MAPK activating protein PM27
, putative MAPK-activating protein PM27
, glutamate transporter EAAC1 interacting protein
, PRA1 family protein-like protein