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anti-Mouse (Murine) Antibodies:
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Mouse (Murine) Polyclonal Arl6ip5 Primary Antibody for IHC (fro), WB - ABIN549007
Lin, Orlov, Ruggiero, Dykes-Hoberg, Lee, Jackson, Rothstein: Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18. in Nature 2001
Show all 3 Pubmed References
Human Polyclonal Arl6ip5 Primary Antibody for ELISA, WB - ABIN249658
Wang, Gong, Chen, Liu, Li, Li, Zhou: JWA regulates XRCC1 and functions as a novel base excision repair protein in oxidative-stress-induced DNA single-strand breaks. in Nucleic acids research 2009
Show all 2 Pubmed References
Glutamate transporter-associated protein 3-18 (GTRAP3-18), an anchor protein that retains interacting proteins in the endoplasmic reticulum, is a critical regulator of food intake and body weight by interacting with POMC. GTRAP3-18-deficient mice showed hypophagia, lean bodies, and lower blood glucose, insulin, and leptin levels with increased serum and brain alpha-MSH levels, leading to AMPK inhibition.
Protective effect of JWA against paraquat neurotoxicity involves regulation of the MEK/PI3K-Nrf2 axis.
the JWA deficiency through cascading FAK-PI3K-Akt-mTOR pathway increases the newborn neurons.
These findings indicated that Arl6ip5 was an anti-catabolic factor by binding with RANKL and disturbing its subcellular trafficking in osteoblast.
Arl6ip5 is a novel regulator of bone formation in osteoblasts.
This study provided evidence that astrocytic JWA expression protects DA neurons from degeneration and plays an important role in neuroprotection via inhibition of ROS and NF-kappaB activation.
The double-fluorescent immunohistochemical analysis revealed that addicsin and TR1 were coexpressed in neurons
Data show the importance of JWA (Arl6ip5) in skin homeostasis and in the process of skin tumor development.
This study demonistrated that GTRAP3-18(-/-) mice performed better in motor/spatial learning and memory tests. The suppression of GTRAP3-18 increases neuronal resistance to oxidative stress by increasing GSH content and also facilitates cognitive function
Arl6ip1 is a novel addicsin-associated partner that promotes EAAC1-mediated glutamate transport activity by decreasing the number of addicsin molecules available for interaction with EAAC1.
98% identity with that of rat GTRAP3-18; upregulated in the amygdala by repeated administration of morphine
Addicsin mRNA is expressed in CNS neurons and may participate in the functional expression of the somatic sensory system by modulation of EAAC1-mediated glutamate transport.
Our studies demonstrated that H(2)O(2) is the primary oxidative product responsible for benzo[a]pyrene (B[a]P)-induced JWA expression, and knockdown of JWA elevates H(2)O(2) (100 microM)- and B[a]P (100 microM)-induced DNA damage.
Expression of GTRAP3-18 delays the ER exit of EAAC1, as well as other members of the excitatory amino acid transporter family.
inhibits EAAT3-mediated glutamate uptake; highly conserved protein and genomic organization amongst vertebrates
These data demonstrated that JWA suppressed the migration/invasion of breast carcinoma cells by downregulating the expression of CXCR4, and suggested that JWA may harbor prognostic and therapeutic potential in patients with breast cancer.
increased RNF185 expression facilitated GC cell migration in vitro and promoted GC metastasis in vivo by downregulating JWA expression.
our results demonstrate that JWA is a novel negative regulator of HER2 expression...in HER2-positive gastric cancer cells
JWA and topoisomerase II alpha regulate each other in tumor cells arrested in G2/M.
the JWA gene may regulate human breast cancer cells through the MAPK signaling pathway using different types of regulation.
This review gives an overview of EAAC1-mediated GSH synthesis, and its regulatory mechanisms by GTRAP3-18 in the brain, and a potential approach against neurodegeneration.
JWA reverses cisplatin resistance via the CK2-XRCC1 pathway in human gastric cancer cells.
data demonstrate that JWA plays a crucial role in HCC progression and suggest JWA may be a potential prognostic biomarker and therapeutic target for HCC.
A significant negative correlation between JWA and ILK in melanoma biopsies.
Loss of JWA expression was strongly correlated with increased gastric cancer angiogenesis.
JWA has an important role in ING4-regulated melanoma angiogenesis, and ING4/JWA/ILK are promising prognostic markers and may be used as anti-angiogenic therapeutic targets for melanoma.
A combined effect of p53 with JWA as efficient prognostic indicators was found for the first time.
JWA plays an important role in the occurrence and progress of human esophageal squamous cell carcinoma (ESCC) and that high expression level of JWA may predict a favorable prognosis in ESCC patients.
JWA and XRCC1 protein levels were downregulated in gastric cancer lesions compared with adjacent noncancerous tissues;JWA and XRCC1 protein expressions in tumor are candidate prognostic markers and predictive factors for benefit from adjuvant platinum-based chemotherapy in resectable gastric carcinoma
The gene polymorphisms at site 76 and GG/CT haploid type of JWA gene were associated with hypertension in workers exposed to high temperature.
PRAF3 plays an important role in the regulation of tumor progression and metastasis and serves as a tumor suppressor in human ESCC. We propose that PRAF3 might be used as a potential therapeutic agent for human ESCC.
JWA night play an important role in neoplastic transformation of HBE cells through regulation of p53 expression.
all-trans retinoic acid increased JWA gene expression in human pulmonary artery smooth muscle cells.
Rsults suggest that JWA can be regulated by oxidative stress and is actively involved in the signal pathways of oxidative stress in the cells.
Expression of this gene is affected by vitamin A. The encoded protein of this gene may be associated with the cytoskeleton. A similar protein in rats may play a role in the regulation of cell differentiation. The rat protein binds and inhibits the cell membrane glutamate transporter EAAC1. The expression of the rat gene is upregulated by retinoic acid, which results in a specific reduction in EAAC1-mediated glutamate transport.
ADP-ribosylation-like factor 6 interacting protein 5
, ADP-ribosylation factor-like 6 interacting protein 5
, ADP-ribosylation factor-like protein 6-interacting protein 5
, ARL-6-interacting protein 5
, PRA1 family protein 3
, glutamate transporter EAAC1-interacting protein
, prenylated Rab acceptor protein 2
, protein JWa
, PRA1 domain family 3
, cytoskeleton related vitamin A responsive protein
, cytoskeleton-related vitamin A-responsive protein
, dermal papilla derived protein 11
, dermal papilla-derived protein 11
, glutamate transporter EEAC1-associated protein
, putative MAPK activating protein PM27
, putative MAPK-activating protein PM27
, glutamate transporter EAAC1 interacting protein
, PRA1 family protein-like protein