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anti-Human SLC38A2 Antibodies:
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Cow (Bovine) Polyclonal SLC38A2 Primary Antibody for WB - ABIN2777727
Zhang, Grewer: The sodium-coupled neutral amino acid transporter SNAT2 mediates an anion leak conductance that is differentially inhibited by transported substrates. in Biophysical journal 2007
Show all 3 Pubmed References
there is a disulfide bond between Cys245 and Cys279 in SNAT2 which has no effect on cell surface trafficking, as well as transporter function
In the absence of SLC1A5 (show SLC1A5 Antibodies) there is a crucial role of SNAT1 (show SLC38A1 Antibodies) in supplying glutamine (show GFPT1 Antibodies) for glutaminolysis with SNAT2 acting as a "backup" for glutamine (show GFPT1 Antibodies) transport.
Propose regulation of placental SNAT2/LAT1 (show LAT Antibodies) ubiquitination by mTORC1 and Nedd4-2 (show NEDD4L Antibodies).
Decreased placental mTOR (show FRAP1 Antibodies) activity causes down-regulation of placental system A activity by shifting SNAT-2 trafficking towards proteasomal degradation, thereby contributing to decreased fetal amino acid availability and restricted fetal growth in IUGR.
GADD34 (show PPP1R15A Antibodies) promotes cell survival and adaptation to increased extracellular osmolarity by increasing the uptake of small neutral amino acids via the amino acid transporter (show SLC43A2 Antibodies) SNAT2.
Increased availability of unsaturated fatty acids can compromise the stress-induced induction/adaptation in SNAT2 expression.
SLC38A1 (show SLC38A1 Antibodies) and SLC38A2 transcript levels are altered in placental malaria with intervillositis.
SNAT2 mRNA levels were significantly decreased in intrauterine growth-restricted placentas with reduced umbilical blood flows.
Placental mRNA expression of system A transporter isoforms SLC38A1 (show SLC38A1 Antibodies) and -2 was lower in teenagers than in adults which may underlie their susceptibility to delivering small-for-gestational-age infants.
findings show methylation status of rRNA differentially influenced the mechanism of 80S complex formation on IRES elements from SNAT2)versus the hepatitis C virus mRNA
Changes in transporter expression likely reflect different amino acid requirements during development. Findings include the differential expression of SNAT1 (show SLC38A1 Antibodies) in the inner and outer cells of the compacted morula and nuclear localisation of SNAT2 in the trophectoderm and placental lineages.
GADD34 (show PPP1R15A Antibodies) promotes cell survival and adaptation to increased extracellular osmolarity by increasing the uptake of small neutral amino acids via the amino acid transporter (show SLC38A7 Antibodies) ATA2.
These data reveal an unexpected role for amino acid uptake and the amino acid transporter (show SLC38A7 Antibodies) SNAT2 in regulation of pluripotent cells in culture.
The inward current of Na(+) associated with the function of SNAT2 leads to membrane depolarization and activation of voltage-sensitive Ca(2 (show CA2 Antibodies)+) channels that mediate Ca(2 (show CA2 Antibodies)+) influx, thereby leading to an increase in the [Ca(2 (show CA2 Antibodies)+)](i) in enteroendocrine cells.
Insulin (show INS Antibodies) promotes the cell surface recruitment of the SAT2/ATA2 system A amino acid transporter (show SLC38A7 Antibodies) from an endosomal compartment in skeletal muscle cells. (ATA2 or SAT2 (show SAT2 Antibodies))
crosstalk between an imprinted growth demand gene (Igf2) and placental supply transporter genes (Slc38a4 (show SLC38A4 Antibodies), Slc38a2, and Slc2a3 (show SLC2A3 Antibodies)) may be a component of the genetic control of nutrient supply and demand during mammalian development
ATA2 on the plasma membrane is subject to polyubiquitination by Nedd4-2 (show NEDD4L Antibodies) with consequent endocytotic sequestration and proteasomal degradation
the insulin (show INS Antibodies)-stimulated translocation pathways for ATA2 and GLUT4 (show SLC2A4 Antibodies) in adipocytes are distinct, involving different storage sites
SNAT2 not only regulates mTOR (show FRAP1 Antibodies) but also regulates proteolysis through PI3K and provides a link among acidosis, insulin (show INS Antibodies) resistance, and protein wasting in skeletal muscle cells.
Despite increased ATF4 (show ATF4 Antibodies) binding at the C/EBP (show CEBPA Antibodies)-ATF composite site following activation of the unfolded protein response, system A transporter 2 (show SLC38A1 Antibodies) (SNAT2) transcription activity is repressed
Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1 (By similarity).
solute carrier family 38, member 2
, Amino acid transporter A2
, sodium-coupled neutral amino acid transporter 2
, sodium-coupled neutral amino acid transporter 2-like
, amino acid transporter A2
, system A amino acid transporter 2
, system A transporter 1
, system N amino acid transporter 2
, amino acid transporter 2
, protein 40-9-1
, solute carrier family 38 member 2
, amino acid system A transporter
, amino acid transporter cationic 2
, amino acid transporter system A2
, amino acid transporter, cationic 2 (low affinity)
, Sodium-coupled neutral amino acid transporter 2
, Solute carrier family 38 member 2
, System A amino acid transporter 2
, System A transporter 1
, System N amino acid transporter 2