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These results revealed that N3-ethylthymidine , but not other DNA lesions, could be repaired by Alkbh2 and Alkbh3 (show ALKBH3 Proteins) in mammalian cells.
studies reveal the ALKBH2 binding interface of PCNA (show PCNA Proteins) and indicate that both germline and somatic ALKBH2 variants could have cellular effects on ALKBH2 function in DNA repair.
It was shown for first time that DNA glycosylase ALKBH2 can repair DNA adduct 1,N2-ethenoguanine.
ABH2 knockdown impairs rDNA transcription and leads to increased single-stranded and double-stranded DNA breaks in the rDNA genes.
Overexpression of ALKBH2 is associated with enhanced resistance to temozolomide in glioblastoma.
ALKBH2 is an upstream molecule of the oncoprotein, MUC1 (show MUC1 Proteins), and regulates cell cycle and EMT (show ITK Proteins), resulting in progression of urothelial carcinomas.
combination of duplex interrogation and oxidation chemistry allows ALKBH2 to detect and process diverse lesions efficiently and correctly
The non-enzymatic binding of AAG (show MPG Proteins) to 3,N(4)-ethenocytosine specifically blocks ALKBH2-catalyzed repair of 3,N(4)-ethenocytosine but not that of methylated ALKBH2 substrates.
X-ray absorption spectroscopy structural investigation of early intermediates in the mechanism of DNA repair by human ABH2
ABH2 is downregulated in a subset of gastric cancers, and might be involved in the molecular mechanism of gastric cancer through inhibiting the proliferation of gastric cancer cells.
ALKBH2 and ALKBH3 (show ALKBH3 Proteins) provide cancer protection similar to that of the DNA glycosylase AAG (show C16orf35 Proteins) and display apparent epistasis with Aag (show C16orf35 Proteins)
Although both Alkbh2 and Alkbh3 (show ALKBH3 Proteins) can protect against methyl methanesulfonate-induced cell death, only Alkbh2 shows statistically significant protection against mutations following treatment with this exogenous methylating agent.
The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 (MIM 610603) are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002
alkB, alkylation repair homolog 2 (E. coli)
, alpha-ketoglutarate-dependent dioxygenase alkB homolog 2
, alpha-ketoglutarate-dependent dioxygenase alkB homolog 2-like
, 2OG-Fe(II) oxy DC1
, DNA oxidative demethylase ALKBH2
, alkylated DNA repair protein alkB homolog 2
, oxy DC1
, AlkB homolog 2