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The crystal structures of the Ku-binding motifs (KBM) of the non-homologous end joining (NHEJ) proteins APLF (A-KBM) and XLF (X-KBM) bound to a Ku-DNA complex are discussed.
The acidic domain of APLF is a histone chaperone that can bind both the histone H2A-H2B dimer and H3-H4 tetramer.
Data provided novel evidence for enrichment of APLF in breast tumors, which could regulate metastasis-associated epithelial-to-mesenchymal transition in invasive breast cancer.
characterization of the interaction of the APLF FHA domain with phosphorylated XRCC1 peptides
These data suggest functional requirements for Ku and XRCC4 in APLF-dependent NHEJ and a unique role for Ku as a factor required to facilitate the nuclear retention of APLF.
APLF promotes the assembly and activity of multi-protein Ku-DNA complexes containing all of the Non-homologous end joining (NHEJ) factors required for DNA ligation.
Polynucleotide kinase and aprataxin-like forkhead-associated protein (PALF) acts as both a single-stranded DNA endonuclease and a single-stranded DNA 3' exonuclease and can participate in DNA end joining in a biochemical system.
only a positive association (OR=1.58, 95% CI 1.05-2.46, P=0.027) was obtained for XRCC1 (Arg280His
APLF has a role in chromosomal DNA double-strand break repair.
The poly(ADP-ribose)-regulated protein APLF as a DNA-damage-specific histone chaperone.
The authors present solution structures of the two poly(ADP-ribose)-binding zinc finger modules of aprataxin and PNK-like factor (APLF), revealing a novel type of zinc finger.
These data identify APLF as a novel component of the cellular response to DNA strand breaks in human cells.
PALF is novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses.
APLF is an ATM target that is involved in nonhomologous end-joining and facilitates double-strand break repair, likely via interactions with Ku and XRCC4-DNA ligase IV.
interaction of poly(ADP-ribose) with a PBZ motif in two representative human proteins, APLF (aprataxin PNK-like factor) and CHFR (checkpoint protein with FHA and RING domains)
Study concludes that APLF can accumulate at sites of chromosomal damage via zinc finger-mediated binding to poly(ADP-ribose) and is a novel component of poly(ADP-ribose) signaling in mammalian cells.
the downregulation of histone chaperone Aprataxin PNK-like factor (APLF) promotes reprogramming by augmenting the expression of E-cadherin.
C2ORF13 is a component of the cellular response to chromosomal DNA single- and double-strand breaks (Iles et al., 2007
aprataxin and PNKP like factor
, aprataxin and PNK-like factor-like
, PNK and APTX-like FHA domain-containing protein
, PNK and APTX-like FHA protein
, XRCC1-interacting protein 1
, aprataxin and PNK-like factor
, aprataxin- and PNK-like factor
, apurinic-apyrimidinic endonuclease APLF