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characterization of the interaction of the APLF FHA (show CRY2 Proteins) domain with phosphorylated XRCC1 (show XRCC1 Proteins) peptides
These data suggest functional requirements for Ku and XRCC4 (show XRCC4 Proteins) in APLF-dependent NHEJ and a unique role for Ku as a factor required to facilitate the nuclear retention of APLF.
APLF promotes the assembly and activity of multi-protein Ku-DNA complexes containing all of the Non-homologous end joining (NHEJ) factors required for DNA ligation.
Polynucleotide kinase and aprataxin-like (show APTX Proteins) forkhead-associated protein (PALF) acts as both a single-stranded DNA endonuclease and a single-stranded DNA 3' exonuclease (show EXO1 Proteins) and can participate in DNA end joining in a biochemical system.
only a positive association (OR=1.58, 95% CI 1.05-2.46, P=0.027) was obtained for XRCC1 (show XRCC1 Proteins) (Arg280His
APLF has a role in chromosomal DNA double-strand break repair.
The poly(ADP-ribose)-regulated protein APLF as a DNA-damage-specific histone chaperone.
The authors present solution structures of the two poly(ADP-ribose)-binding zinc finger modules of aprataxin and PNK-like factor (APLF), revealing a novel type of zinc finger.
These data identify APLF as a novel component of the cellular response to DNA strand breaks in human cells.
PALF is novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses.
the downregulation of histone chaperone Aprataxin (show APTX Proteins) PNK (show PNKP Proteins)-like factor (APLF) promotes reprogramming by augmenting the expression of E-cadherin (show CDH1 Proteins).
C2ORF13 is a component of the cellular response to chromosomal DNA single- and double-strand breaks (Iles et al., 2007
aprataxin and PNKP like factor
, aprataxin and PNK-like factor-like
, PNK and APTX-like FHA domain-containing protein
, PNK and APTX-like FHA protein
, XRCC1-interacting protein 1
, aprataxin and PNK-like factor
, aprataxin- and PNK-like factor
, apurinic-apyrimidinic endonuclease APLF