Browse our APLF Proteins (APLF)

Full name:: Aprataxin and PNKP Like Factor Proteins (APLF)

On www.antibodies-online.com are 5 Aprataxin and PNKP Like Factor (APLF) Proteins from 3 different suppliers available. Additionally we are shipping APLF Antibodies (48) and and many more products for this protein. A total of 55 APLF products are currently listed.

Synonyms:: 2010301N04Rik, AI452191, APFL, APLF, C2orf13, DKFZp459J1223, PALF, RGD1565557, Xip1

list all proteins	Gene Name	GeneID	UniProt
	APLF	200558	Q8IW19
	APLF	72103	Q9D842
Rat APLF	APLF	500247
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APLF Proteins (APLF) by Origin

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Relevant Pathways for APLF Proteins

DNA Damage Repair

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Human Aprataxin and PNKP Like Factor (APLF) interaction partners

characterization of the interaction of the APLF FHA domain with phosphorylated XRCC1 peptides
These data suggest functional requirements for Ku and XRCC4 in APLF-dependent NHEJ and a unique role for Ku as a factor required to facilitate the nuclear retention of APLF.
APLF promotes the assembly and activity of multi-protein Ku-DNA complexes containing all of the Non-homologous end joining (NHEJ) factors required for DNA ligation.
Polynucleotide kinase and aprataxin-like forkhead-associated protein (PALF) acts as both a single-stranded DNA endonuclease and a single-stranded DNA 3' exonuclease and can participate in DNA end joining in a biochemical system.
only a positive association (OR=1.58, 95% CI 1.05-2.46, P=0.027) was obtained for XRCC1 (Arg280His
APLF has a role in chromosomal DNA double-strand break repair.
The poly(ADP-ribose)-regulated protein APLF as a DNA-damage-specific histone chaperone.
The authors present solution structures of the two poly(ADP-ribose)-binding zinc finger modules of aprataxin and PNK-like factor (APLF), revealing a novel type of zinc finger.
These data identify APLF as a novel component of the cellular response to DNA strand breaks in human cells.
PALF is novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses.
APLF is an ATM target that is involved in nonhomologous end-joining and facilitates double-strand break repair, likely via interactions with Ku and XRCC4-DNA ligase IV.
interaction of poly(ADP-ribose) with a PBZ motif in two representative human proteins, APLF (aprataxin PNK-like factor) and CHFR (checkpoint protein with FHA and RING domains)
Study concludes that APLF can accumulate at sites of chromosomal damage via zinc finger-mediated binding to poly(ADP-ribose) and is a novel component of poly(ADP-ribose) signaling in mammalian cells.

Mouse (Murine) Aprataxin and PNKP Like Factor (APLF) interaction partners

the downregulation of histone chaperone Aprataxin PNK-like factor (APLF) promotes reprogramming by augmenting the expression of E-cadherin.
APLF has a role in chromosomal DNA double-strand break repair.

APLF Protein Profile

Protein Summary

C2ORF13 is a component of the cellular response to chromosomal DNA single- and double-strand breaks (Iles et al., 2007

Alternative names and synonyms associated with APLF

aprataxin and PNKP like factor (APLF)
aprataxin and PNKP like factor (aplf)
aprataxin and PNKP like factor (Aplf)

2010301N04Rik protein
AI452191 protein
APFL protein
APLF protein
C2orf13 protein
DKFZp459J1223 protein
PALF protein
RGD1565557 protein
Xip1 protein

Protein level used designations for APLF

aprataxin and PNKP like factor , aprataxin and PNK-like factor-like , PNK and APTX-like FHA domain-containing protein , PNK and APTX-like FHA protein , XRCC1-interacting protein 1 , aprataxin and PNK-like factor , aprataxin- and PNK-like factor , apurinic-apyrimidinic endonuclease APLF

GENE ID	SPECIES
481405	Canis lupus familiaris
705875	Macaca mulatta
100061683	Equus caballus
100127823	Xenopus (Silurana) tropicalis
100173335	Pongo abelii
100342776	Oryctolagus cuniculus
100389227	Callithrix jacchus
100595038	Nomascus leucogenys
200558	Homo sapiens
72103	Mus musculus
507989	Bos taurus
500247	Rattus norvegicus

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