BARD1 Proteins

Protein Summary

This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer.

Alternative names and synonyms associated with BARD1

• BRCA1 associated RING domain 1 (BARD1) antibody
• BRCA1 associated RING domain 1 (bard1) antibody
• BRCA1 associated RING domain 1 (Bard1) antibody

• BARD1 antibody
• ENSMUSG00000060893 antibody
• ENSMUSG00000073653 antibody
• LOC100147913 antibody

Protein level used designations for BARD1

BRCA1 associated RING domain 1 , BRCA1-associated RING domain protein 1-like , BRCA1 associated RING domain 1 isoform alfa , BRCA1 associated RING domain 1 isoform beta , BRCA1 associated RING domain 1 isoform delta , BRCA1 associated RING domain 1 isoform epsilon , BRCA1 associated RING domain 1 isoform eta , BRCA1 associated RING domain 1 isoform gamma , BRCA1 associated RING domain 1 isoform phi , BRCA1-associated RING domain gene 1 , BRCA1-associated RING domain protein 1 , BARD-1