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This study demonstrated that the Cerebellar Abiotrophy associated single nucleotide polymorphism introduces a new binding site for a novel transcription factor (Myelin Transcription Factor-1 Like protein, MYT1L). and Cerebellar Abiotrophy-affected horses show differential expression of a specific isoform of MUTYH as well as different localization in the Purkinje and granular neurons of the cerebellum.
qPCR analysis of cDNA from the cerebella of affected and unaffected horses suggested that MUTYH expression is down-regulated in affected horses.
The MUTYH gene presents downregulation in the more advanced stages of colorectal cancer
MUTYH variants among Japanese colorectal polyposis patients.
Our results suggest that p.(Gly396Asp) in MUTYH, and potentially other mutations in additional members of the same DNA excision-repair pathway (such as the OGG1 (show OGG1 Proteins) gene) might be involved in driving the tumorigenesis leading to familial and sporadic small intestinal neuroendocrine tumors .
Knockdown of MYH in pancreatic cancer cells reduces tumor growth and sensitizes cells to antineoplastic agents.
Rheumatoid arthritis is associated with increased serum level of the MUTYH protein.
Inactivating MUTYH germline mutations are associated with high-grade midline gliomas.
this review focuses on multifaceted roles of MUTYH in the cell, both in the prevention of mutagenesis and tumorigenesis
Acetohexamide exerted this protective function by antagonizing expression of the DNA glycosylase, MUTYH. Together, our data reveal the existence of an NER (show NR1H2 Proteins)-independent mechanism to remove UV-induced DNA damage and prevent cell death.
Data indicate that DNA glycosylases MYH, UNG2 (show CCNO Proteins), MPG (show MPG Proteins), NTH1, NEIL1 (show NEIL1 Proteins), 2 and 3 on nascent DNA.
No biallelic mutation carriers for the MUTYH variants c.536A.G p.Tyr179Cys (Y179C) in exon 7 and c.1187G.A p.Gly396Asp (G396D) in exon 13 was found, after screening with a novel high resolution melt curve (HRM) analysis assay.
results suggested that MYH, which interacts with TRADD (show TRADD Proteins), inhibits TNF-alpha (show TNF Proteins) necroptotic signaling. Therefore, MYH inactivation is essential for necroptosis via the downregulation of caspase-8 (show CASP8 Proteins).
Ogg1 (show OGG1 Proteins) and Mutyh regulate hippocampal gene expression related to cognition and behavior, suggesting a role for the glycosylases in regulating adaptive behavior.
MUTYH loss is associated with an increase in inflammation associated colorectal cancer risk, which involves immunosuppression and altered inflammatory response.
Results show that MYH is a vital DNA repair enzyme (show LIG4 Proteins) that protects cells from oxidative DNA damage and is critical for a proper cellular response to DNA damage.
a 5-methylcytosine glycosylase activity for the murine DNA base excision repair enzyme Myh is described and shown that it is critically involved in remodeling the IL-2 (show IL2 Proteins) Promoter for transcription.
Data indicate that maternal folate depletion during pregnancy and high-fat feeding from weaning altered gene expression of Ogg1 (show OGG1 Proteins), Neil1 (show NEIL1 Proteins), Mutyh and Xrcc1 (show XRCC1 Proteins) in the brain of adult offspring.
The action of MUTYH, which initiates excision repair of adenine opposite 8-oxoG, triggers neurodegeneration in mice.
OGG1 (show OGG1 Proteins) and MYH appear to be dispensable for antimutator function in mitochondria.
Mutyh plays a major role in maintaining intestinal integrity by affecting the inflammatory response.
Aim of this study was to characterize the biological effects, in a mammalian cell background, of human MUTYH mutations identified in MUTYH-associated polyposis patients
This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
mutY homolog (E. coli)
, A/G-specific adenine DNA glycosylase
, A/G-specific adenine DNA glycosylase-like
, mutY homolog
, adenine-DNA glycosylase
, mutY homolog alpha
, the full-length form type A, 5' region