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anti-Mouse (Murine) RAD51 Antibodies:
anti-Human RAD51 Antibodies:
anti-Rat (Rattus) RAD51 Antibodies:
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Caenorhabditis elegans (C. elegans) Monoclonal RAD51 Primary Antibody for ChIP, ICC - ABIN151080
Chen, Chen, Chen, Xiao, Sharp, Lee: The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment. in Proceedings of the National Academy of Sciences of the United States of America 1998
Show all 39 Pubmed References
Human Polyclonal RAD51 Primary Antibody for - ABIN966937
Liang, Caporaso, McMaster, Ng, Landgren, Yeager, Chanock, Goldin: Common genetic variants in candidate genes and risk of familial lymphoid malignancies. in British journal of haematology 2009
Show all 4 Pubmed References
Human Monoclonal RAD51 Primary Antibody for WB - ABIN1944894
Shinohara, Ogawa, Matsuda, Ushio, Ikeo, Ogawa: Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA. in Nature genetics 1993
Show all 5 Pubmed References
Human Monoclonal RAD51 Primary Antibody for IHC, WB - ABIN151942
Gultice, Kulkarni-Datar, Brown: Hypoxia-inducible factor 1alpha (HIF1A) mediates distinct steps of rat trophoblast differentiation in gradient oxygen. in Biology of reproduction 2008
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Human Polyclonal RAD51 Primary Antibody for ICC, IF - ABIN4349123
Gabriel, Roedl, Gordon, Djabali: Sulforaphane enhances progerin clearance in Hutchinson-Gilford progeria fibroblasts. in Aging cell 2015
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Human Polyclonal RAD51 Primary Antibody for IF, IP - ABIN2452096
Vaz, Hanenberg, Schuster, Barker, Wiek, Erven, Neveling, Endt, Kesterton, Autore, Fraternali, Freund, Hartmann, Grimwade, Roberts, Schaal, Mohammed, Rahman, Schindler, Mathew: Mutation of the RAD51C gene in a Fanconi anemia-like disorder. in Nature genetics 2010
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Human Polyclonal RAD51 Primary Antibody for IHC (p), WB - ABIN519604
Jeyasekharan, Liu, Hattori, Pisupati, Jonsdottir, Rajendra, Lee, Sundaramoorthy, Schlachter, Kaminski, Ofir-Rosenfeld, Sato, Savill, Ayoub, Venkitaraman: A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization. in Nature structural & molecular biology 2013
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Human Polyclonal RAD51 Primary Antibody for IF, IP - ABIN2668603
Bennett, Knight: Cellular localization of human Rad51C and regulation of ubiquitin-mediated proteolysis of Rad51. in Journal of cellular biochemistry 2005
Yeast (Saccharomyces cerevisiae) Polyclonal RAD51 Primary Antibody for ChIPSeq, IF - ABIN2452090
Ribeyre, Shore: Anticheckpoint pathways at telomeres in yeast. in Nature structural & molecular biology 2012
Human Polyclonal RAD51 Primary Antibody for ChIPSeq, IP - ABIN2452091
Tashiro, Walter, Shinohara, Kamada, Cremer: Rad51 accumulation at sites of DNA damage and in postreplicative chromatin. in The Journal of cell biology 2000
The anti-recombinase (show RAG1 Antibodies) activity of BLM (show BLM Antibodies) is of general importance for normal retention of RAD51 at DNA double strand break sites and regulation of homologous recombination.
involvement of ZNF281 (show ZNF281 Antibodies) in the cellular response to genotoxic stress through the control exercised on the expression of genes that act in different repair mechanisms
Our results thus help establish the functional relevance of the trimeric RAD51-SWI5-SFR1 (show SFR1 Antibodies) complex and provide insights into the mechanistic underpinnings of homology-directed DNA repair in mammalian cells.
Unlike directly induced DSBs, secondary DSBs were not efficiently repaired, although Rad51 and 53BP1 (show TP53BP1 Antibodies) were recruited to these sites. H2AX (show H2AFX Antibodies) was dramatically stabilized in response to DSBs directly caused by gamma-rays, enabling gammaH2AX (show H2AFX Antibodies) foci formation and DSB repair, whereas H2AX (show H2AFX Antibodies) was barely stabilized in response to secondary DSBs, in which gammaH2AX (show H2AFX Antibodies) foci were small and DSBs were not efficiently repaired
HOP2 (show PSMC3IP Antibodies)-MND1 (show MND1 Antibodies) enhances the interaction of RAD51 with nucleotide cofactors and modifies its DNA-binding specificity.
Rad51 repaired DNA damage.
BRCA2 (show BRCA2 Antibodies)-mediated sequestration of nuclear RAD51 serves to prevent inappropriate DNA interactions.
increased Rad51 concentration and homology length interact synergistically to promote 3' extension, presumably as a result of enhanced Brca2 (show BRCA2 Antibodies)-mediated Rad51 polymerization
Results suggest that cellular levels of Brca2 (show BRCA2 Antibodies) and Rad51 are mutually dependent on each other, and that low levels of these proteins provide selective pressure for reduction of p53 (show TP53 Antibodies), which permits cell growth
FBH1 (show FBXO18 Antibodies) restraining RAD51 DNA binding under unperturbed growth conditions to prevent unwanted or unscheduled DNA recombination.
Although the presence of RAD51 protein provides essential support for the action of DMC1 (show DMC1 Antibodies), these results show no significant effect of the absence of RAD51 strand-exchange activity on meiotic crossing-over rates or patterns in different chromosomal regions or across the whole genome of Arabidopsis, strongly supporting the argument that DMC1 (show DMC1 Antibodies) catalyses repair of all meiotic DNA breaks, not only non-sister cross-overs.
The authors find that RBR1 is also required for RAD51 localization to DNA lesions.
RAD51 forms a protein complex with AtRAD51C (show RAD51C Antibodies)-AtXRCC3 to facilitate RAD51 localization on chromosomes for meiotic recombination.
Our data demonstrate that RAD51 plays a supporting role for DMC1 (show DMC1 Antibodies) in meiotic recombination in the flowering plant, Arabidopsis.
The present study demonstrates for the first time the involvement of a host RAD51 protein in mungbean yellow mosaic India virus replication.
Results demonstrate that DMC1 functions independently and spatially separated from RAD51 during meiosis and that ATR is an integral part of the regular meiotic program.
Establishment and stabilisation of pairing of homologous centromeric and pericentromeric regions depends principally upon DMC1 (show DMC1 Antibodies), while pairing and synapsis of euchromatic chromosome arms of homologues requires the presence of RAD51
AtRAD51 is required to ensure the fidelity of homologous recombination during interchromosomal exchanges. It may also be required to ensure the fidelity of homologous recombination in the interchromosomal exchanges initiated by AtDMC1.
AtBRCA2 is required for proper meiotic synapsis and mediates the recruitment of AtRAD51 and AtDMC1.
Study provides the molecular evidence showing that the BRCA2 (show BRCA2 Antibodies)-RAD51 complex, known for its function in HR, also plays a direct and specific role in transcription regulation during plant immune responses.
The complete cDNA sequences of the pig RAD51, RAD52 (show RAD52 Antibodies), and RAD54 (show RAD54L Antibodies) genes, which are closely related to homologous recombination events, arae identified using molecular cloning technique in pigs.
Meiosis progression and female age affect expression profile of DNA repair RAD51 gene in bovine oocytes.
RAD51 plays a crucial role in halting cell death program induced by ionizing radiation in bovine oocytes.
Histone deacetylases 1 and 2 cooperate in regulating BRCA1, CHK1 (show CHEK1 Antibodies), and RAD51 expression in acute myeloid leukemia (show BCL11A Antibodies) cells.
BRCA1-BARD1 (show BARD1 Antibodies) mutants with weakened RAD51 interactions show compromised DNA joint formation and impaired mediation of homologous recombination and DNA repair in cells; results identify a late role of BRCA1-BARD1 (show BARD1 Antibodies) in homologous recombination, an attribute of the tumour suppressor complex that could be targeted in cancer therapy
Our data suggest that in both BRCA1-mutant and BRCA1-wild-type TNBCs, CSCs are relatively resistant to PARP (show COL11A2 Antibodies) inhibition. This resistance is mediated by RAD51, suggesting that strategies aimed at targeting RAD51 may increase the therapeutic efficacy of PARPi
Data show that the combination of targeting RAD51 and p38 (show CRK Antibodies) inhibits cell proliferation both in vitro and in vivo, which was further enhanced by targeting of PARP1 (show PARP1 Antibodies).
Data suggest that oleandrin may be a potential anti-tumor agent by suppressing the expression of RAD51 recombinase (show RAG1 Antibodies).
we demonstrated that Y54 phosphorylation enhances the RAD51 recombinase activity by at least two different mechanisms, modifies the RAD51 nucleoprotein filament formation, and allows RAD51 to compete efficiently with ssDNA binding protein RPA.
Mutations F86L & E258A affect the multimerization/BRCA2 (show BRCA2 Antibodies) binding region of RAD51.Both variants exhibit altered thermal stability,reduced DNA binding affinity,reduced ATPase (show DNAH8 Antibodies) activity compared to wild-type. F86L efficiently catalyzes DNA strand exchange reactions,whereas strand exchange activity of E258A is severely reduced.Mixtures of either variant with wild-type RAD51 exhibit strong defects in DNA strand exchange activity
Data indicate that lupus autoantibody 3E10 directly binds to the N-terminus of RAD51 recombinase (show RAG1 Antibodies), sequesters RAD51 in the cytoplasm, and impedes RAD51 binding to DNA.
Study suggested that RAD51, XRCC1 (show XRCC1 Antibodies), and XRCC3 (show XRCC3 Antibodies) polymorphisms may be predictive factors for radiation-induced acute toxicity in rectal cancer patients treated with preoperative combined therapy.
n metastatic high grade clear cell carcinoma, this expression was more pronounced. Though we could not demonstrate direct correlation, we showed that epigenetic modification by methylation is associated with decreased genomic translation of Rad51.
Brca2 (show BRCA2 Antibodies) and Rad51 prevent formation of abnormal DNA replication intermediates, whose processing by Smarcal1 (show SMARCAL1 Antibodies) and Mre11 (show MRE11A Antibodies) predisposes to genome instability.
Data show that MRE11 (show MRE11A Antibodies)- and RAD51-dependent fork repair leading to reloading of the GINS onto the MCM-CDC45 (show CDC45 Antibodies) complex still engaged with the DNA could be sufficient to restore a functional CDC45 (show CDC45 Antibodies)-MCM-GINS (CMG (show CASK Antibodies)) helicase (show DNA2 Antibodies) complex.
By promoting CtIP (show RBBP8 Antibodies)-dependent resection of double-strand break (DSB) ends while preventing Rad51 chromatin assembly, Cdk1 (show CDK1 Antibodies) inhibits both the nonhomologous and homologous modes of DSB repair during mitosis.
Rad51 has a role at the replication fork protecting DNA from Mre11 (show MRE11A Antibodies)-dependent degradation.
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene.
DNA repair protein XRCC2
, X-ray repair cross-complementing protein 2
, recA/RAD51 family protein
, DNA repair protein RAD51 homolog 1
, RAD51 homolog A
, RAD51 homolog (RecA homolog, E. coli)
, homolog to S.cerevisiae
, DNA repair protein RAD51
, DNA repair protein RAD51-like 1
, BRCA1/BRCA2-containing complex, subunit 5
, RecA, E. coli, homolog of
, RecA-like protein
, recombination protein A
, RAD51 homolog
, DNA repair protein RAD51 homolog A
, RAD51 homolog (RecA homolog)