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Notwithstanding their clearly established importance for RAD51-dependent homologous recombination, XRCC2, RAD51B and RAD51D thus also participate in Single-Strand Annealing recombination.
The genome stability of the Arabidopsis thaliana mutants deficient in ATM (show ATM Proteins) (communication between DNA strand break recognition and the repair machinery), KU80 (show XRCC5 Proteins) (deficient in NHEJ) and RAD51B (deficient in HR repair) genes, was investigated.
The roles of RAD51B and XRCC2 in recombination are thus not limited to mitotic cells.
Results suggest that AtRAD51B gene product is involved in the repair of double-strand DNA breaks via homologous recombination. [Rad51B]
Our study shows that a miR (show MLXIP Proteins)-590/Acvr2a (show ACVR2A Proteins)/Rad51b signaling axis ensures the stabilization of mESCs by balancing DNA damage repair and rapid proliferation during self-renewal.
hypermethylation of homologous recombination DNA repair genes including RAD51B and XRCC3 (show XRCC3 Proteins) is associated with an inflamed phenotype in squamous cell cancers of the head and neck, lung and cervix.
our study suggested that miRNA-binding site genetic variants of RAD51B may modify the susceptibility to cervical cancer, which is important to identify individuals with differential risk for this malignancy and to improve the effectiveness of preventive intervention.
over-expression of RAD51B promoted cell proliferation, aneuploidy, and drug resistance, while RAD51B knockdown led to G1 arrest and sensitized cells to 5-fluorouracil
The aim of the present study was to evaluate the relationship between prostate cancer risk and the presence of single nucleotide polymorphisms in the genes involved in Homologous recombination repair, RAD51 (show RAD51 Proteins), RAD51B, XRCC2 (show XRCC2 Proteins) and XRCC3 (show XRCC3 Proteins).
a novel germ line RAD51B nonsense mutation, and reduced expression of RAD51B in melanoma cells indicating inactivation of RAD51B
Mutations in epithelial ovarian cancer cases were more frequent in RAD51C (show RAD51C Proteins) (14 occurrences, 0.41%) and RAD51D (12 occurrences, 0.35%) than in RAD51B (two occurrences, 0.06%).
the risk of developing AMD (show AMD1 Proteins) exhibits dose dependency as well as an epistatic combined effect in rs17105278 T>C and rs4902566 C>T carriers and that the elevated risk for rs17105278 T>C carriers may be due to decreased transcription of RAD51B.
Relative excess risk of breast cancer due to interaction between RAD51L1 single-nucleotide polymorphism and BMI.
Data indicate that complement factor H (CFH (show CFH Proteins)) R1210C and common variants in COL8A1 (show COL8A1 Proteins) and RAD51B plus six genes contribute predictive information for advanced macular degeneration (AMD (show AMD1 Proteins)) beyond macular and behavioral phenotypes.
It confirms that RAD51 (show RAD51 Proteins) paralog mutations confer breast and ovarian cancer predisposition and are rare events.
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. At least three alternatively spliced transcript variants encoding distinct isoforms have been observed. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata.
Rad51 DNA recombinase 2
, DNA repair protein RAD51 homolog 2
, RAD51-like 1
, RAD51-like protein 1
, RAD51 homolog B
, RecA-like protein
, recombination repair protein