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Human Monoclonal RAD54L Primary Antibody for CyTOF, FACS - ABIN257916
Srivastava, Modi, Tripathi, Mudgal, De, Sengupta: BLM helicase stimulates the ATPase and chromatin-remodeling activities of RAD54. in Journal of cell science 2009
Human Polyclonal RAD54L Primary Antibody for ICC, IF - ABIN4349162
Bai, Wang, Huo, Xie, Xie, Xu, Wang: Serine/Threonine Kinase CHEK1-Dependent Transcriptional Regulation of RAD54L Promotes Proliferation and Radio Resistance in Glioblastoma. in Translational oncology 1970
Data show that the RAD54 (show ATRX Antibodies) N-terminal domain (NTD) is responsible for initiation of branch migration (BM) through two coupled, but distinct steps; specific binding to Holliday junctions and RAD54 (show ATRX Antibodies) oligomerization.
Nap1 (show IL8 Antibodies) binds to RAD54 (show ATRX Antibodies).
TAF12 (show TAF12 Antibodies) and NFYC (show NFYC Antibodies) are transcription factors that regulate the epigenome, whereas RAD54L (show ATRX Antibodies) plays a central role in DNA repair
support a model in which RAD54L (show ATRX Antibodies) and RAD54B (show RAD54B Antibodies) counteract genome-destabilizing effects of direct binding of RAD51 (show RAD51 Antibodies) to dsDNA in tumor cells
The RAD54L (show ATRX Antibodies) polymorphism (2290C/T) can be used as a genetic marker inside the consensus deletion region at 1p32 in human meningiomas.
Shortened telomeres in murine scid (show PRKDC Antibodies) cells expressing mutant RAD54L (show ATRX Antibodies) coincide wirth reduction in recombination at telomeres.
hRad54, a Swi2/Snf2 (show SMARCA2 Antibodies) protein, binds HJ-like structures with high specificity and promotes their bidirectional branch migration in an ATPase (show DNAH8 Antibodies)-dependent manner
Some immortal cells use the alternative lengthening of telomeres (ALT) pathway to maintain their telomeres instead of telomerase. This is the first genetic evidence that Rad54 is dispensable for the ALT pathway.
RAD54 (show ATRX Antibodies) is recruited by RAD51 (show RAD51 Antibodies)-ssDNA filament to the chromatin of the intact chromosome and it remodels that chromatin to facilitate accessibility for strand exchange
analysis of human rad54 (show ATRX Antibodies) protein interactions with branched DNA molecules
Our study highlights the importance of the cooperation between Rad54 and Mus81 (show MUS81 Antibodies) for mediating DNA DSB repair and restraining chromosome missegregation.
Rad54 is not required for either transgene isotype switching or transgene hypermutation.
Rad54-mediated homologous recombination is not essential for somatic hypermutation. In addition, the finding that the ablation of RAD51 (show RAD51 Antibodies) paralogues causes an increase in SHM (show CNTNAP1 Antibodies) argues against a direct involvement of HR in promoting SHM (show CNTNAP1 Antibodies).
Rad54 has a role in telomere length maintenance
Rad54 cooperates with DNA Ligase IV (show LIG4 Antibodies) to support cellular proliferation, dna repair, and prevent chromosome and single chromatid aberrations
Mus81 (show MUS81 Antibodies)-Eme1- and Rad54-mediated homologous recombination are involved in the same DNA replication-dependent interstrand crosslinks repair pathway
These results reveal a differential interaction of the ATM (show ATM Antibodies)-mediated DNA damage response and Rad54 paralog-mediated homologous recombination depending on the DNA damaging agent that initiates the response.
Rad54 structure suggests that SWI2/SNF2 (show SMARCA4 Antibodies) proteins use a mechanism analogous to helicases to translocate on dsDNA
The protein encoded by this gene belongs to the DEAD-like helicase superfamily, and shares similarity with Saccharomyces cerevisiae Rad54, a protein known to be involved in the homologous recombination and repair of DNA. This protein has been shown to play a role in homologous recombination related repair of DNA double-strand breaks. The binding of this protein to double-strand DNA induces a DNA topological change, which is thought to facilitate homologous DNA paring, and stimulate DNA recombination. Alternative splicing results in multiple transcript variants encoding the same protein.
DNA repair and recombination protein RAD54-like
, RAD54 homolog
, putative recombination factor GdRad54
, RAD54-like protein
, RAD54-like (S. cerevisiae)