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RMI1 knockdown cells exhibit accumulation of broken DNAs after being released from hydroxyurea treatment. Moreover, we demonstrate that RMI1 facilitates the recovery from activated checkpoint and resuming the cell cycle after replicative stress.
RMI1 protein level does not change through G1, S and G2 phases, but significantly increases in M phase.
a model that maps all functionally important structural features for yeast Rmi1 and structure-prediction-based alignment with the recently established crystal structure of the N-terminus of human Rmi1, is proposed.
The results show that Topo IIIalpha stimulates DNA unwinding by BLM in a manner that is potentiated by RMI1-RMI2, and that the processivity of resection is reliant on the Topo IIIalpha-RMI1-RMI2 complex.
two proteins that interact with BLM, RMI1 and RMI2, are phosphorylated upon SAC activation, and, like BLM, RMI1, and RMI2, are phosphorylated in an MPS1-dependent manner.
RMI1 is required to promote normal replication fork progression
Crystal structures of RMI1 and RMI2, two OB-fold regulatory subunits of the BLM complex
human topoisomerase IIIalpha functions as a decatenase with the assistance of BLM and RMI1 to facilitate the processing of homologous recombination intermediates without crossing over as a mechanism to preserve genome integrity
No evidence was found for an association between RMI1 S455N (rs1982151) and colorectal cancer risk.
BLAP75/RMI1 acts by recruiting TOPO IIIalpha to double Holliday junctions
BLM, Topo IIIalpha, and BLAP75 constitute a dissolvasome complex that processes HR intermediates to limit DNA crossover formation
BLM is stably associated with RMI1 protein.
Genetic variant of the human homologous recombination-associated gene RMI1 is associated with acute myeloid leukemia, myelodysplatic syndromes and malignant melanoma
evolutionarily conserved N-terminal third of BLAP75 mediates complex formation with BLM and Topo IIIalpha and that the DNA binding activity resides in the C-terminal third of this novel protein.
Individuals carrying genetic variants of the BLM-TOP3A-RMI1 complex have an increased risk of acute myeloid leukemia/myelodysplatic syndromes, malignant melanoma, bladder and breast cancer.
results demonstrate the importance of RMI1 in maintaining genome integrity and normal embryonic development
Glucose regulates RMI1 expression through the E2F pathways in adipose cells.
These results demonstrated a dual-role of RMI1 in embryonic development and tumor suppression.
results suggest that the regulation of energy balance by RMI1 is attributable to the regulation of food intake and E2F8 expression in adipose tissue.
RMI1 is a component of protein complexes that limit DNA crossover formation via the dissolution of double Holliday junctions (Raynard et al., 2006
BLM-associated polypeptide, 75 kDa
, BLM-associated protein 75 kDa
, RMI1, RecQ mediated genome instability 1, homolog
, homolog of yeast RecQ-mediated genome instability 1 (RMI1)
, recQ-mediated genome instability protein 1
, RecQ mediated genome instability 1