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Study suggested that RAD51 (show RAD51 Proteins), XRCC1 (show XRCC1 Proteins), and XRCC3 polymorphisms may be predictive factors for radiation-induced acute toxicity in rectal cancer patients treated with preoperative combined therapy.
XRCC1 Arg399Gln Gln/Gln genotype, Gln allele, and homozygote variants of XRCC3 Thr241Met polymorphism may be a risk factor for predisposition of Oral Squamous Cell Carcinoma in Turkish. In addition, XRCC3 Thr241Met genotype could be associated with tumor size and level of daily smoking.
The combined AA/AA (show TEAD1 Proteins) genotype and GG/GA genotype frequencies for rs1799794 and rs709399 polymorphisms were significantly higher in thyroid cancer patients compared to control group when compared with combined AA/GG genotype as reference.
the association of six non-synonymous coding variants from XRCC1 (show XRCC1 Proteins), XRCC3 and XPD (show ERCC2 Proteins) genes with hepatocellular carcinoma risk, was assessed.
The analysis results showed that the following polymorphisms were correlated with susceptibility to lung cancer: rs4646903 in CYP1A1 (show CYP1A1 Proteins) (P < 0.001), rs1048943 in CYP1A1 (show CYP1A1 Proteins) (P < 0.001), rs1695 in GSTP1 (show GSTP1 Proteins) (P < 0.05), rs13181 in ERCC2 (show ERCC2 Proteins) (P < 0.001), and rs25487 in XRCC1 (show XRCC1 Proteins) (P < 0.05); no such correlation existed in rs861539 in XRCC3 (P > 0.05).
based on the evidence from the large-scale case-control study and meta-analysis, the rs861539 within XRCC3 gene was associated with the risk of NPC (show NPC1 Proteins) under recessive model.
our study suggested that the polymorphism of rs861539 in XRCC3 was associated with increased risk of PTC (show F9 Proteins).
XRCC3-Met allele seems to contribute to the development of OSCC, metastases and more advanced stages in these lesions.
This meta-analysis suggested that the XRCC3 rs861539 polymorphism was not a risk factor for cutaneous melanoma susceptibility. [meta-analysis]
Results indicate that eight polymorphisms of XRCC1 (show XRCC1 Proteins), XRCC2 (show XRCC2 Proteins), and XRCC3 gene might be related to individual susceptibility to differentiated thyroid cancer (DTC) in Chinese population suggesting that XRCC1 (show XRCC1 Proteins) (rs25487, rs25489, rs1799782), XRCC2 (show XRCC2 Proteins) (rs3218536), and XRCC3 (rs1799794, rs56377012, rs1799796, rs861539) are novel genetic risk markers for DTC.
the RAD51C-XRCC3-associated Holliday junction resolvase complex associates with crossovers and may play an essential role in the resolution of recombination intermediates prior to chromosome segregation
This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified.
DNA repair protein XRCC3
, X-ray repair cross-complementing protein 3
, X-ray repair complementing defective repair in Chinese hamster cells 3
, DNA-repair protein XRCC3