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Full name:: X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) Proteins (XRCC5)

On www.antibodies-online.com are 4 X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5) Proteins from 3 different suppliers available. Additionally we are shipping XRCC5 Antibodies (253) and XRCC5 Kits (20) and many more products for this protein. A total of 293 XRCC5 products are currently listed.

Synonyms:: AI314015, KARP-1, KARP1, KU80, Ku86, KUB2, Kup80, NFIV, XRCC5, xrcc5-a

list all proteins	Gene Name	GeneID	UniProt
	XRCC5	22596	P27641
Rat XRCC5	XRCC5	363247
	XRCC5	7520	P13010
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XRCC5 Proteins (XRCC5) by Origin

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Relevant Pathways for XRCC5 Proteins

DNA Damage Repair

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More Proteins for XRCC5 Interaction Partners

Mouse (Murine) X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5) interaction partners

RT-PCR and immunobloting data show that inhibitory effect of sodium butyrate takes place at the level of Rad51 (show RAD51 Proteins) and XRCC5 gene transcription and the content of Rad51 (show RAD51 Proteins) and Ku80 proteins.
Ku (ku70 (show XRCC6 Proteins)/ku80 heterodimer)roles in nonhomologous end joining and base excision repair pathways of DNA repair are overviewed.
the downregulation of Ku80 and an impairment of repair activity in squamous cells, which are mediated by miR (show MLXIP Proteins)-31.
Inactivation of Ku80 and DNA-PKCS (show PRKDC Proteins) causes reduced lifespan and bodyweight.
A novel role for free Ku70 (show XRCC6 Proteins) and free Ku80 in altering base excision repair.
Ku80 plays an important role in base excision repair.
Ku70/80 binds to DNA double strand breaks (DSB) in all cell cycle stages and is likely actively displaced from DSB ends to free the DNA ends for DNA end resection and thus homologous recombination to occur.
There was a dose-dependent and time-dependent increase in Ku80 mRNA levels in nude mice that were inoculated with A549 cells and exposed to varying doses of irradiation.
Ku70 (show XRCC6 Proteins)/86 binds to the Apaf1 (show APAF1 Proteins) promoter and represses its activity.
Mobility of a major portion of Ku80 is not affected by DNA double strans breaks (DSBs) in order to find other DSBs in hamster cells.

Human X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5) interaction partners

ATM (show ATM Proteins)-dependent phosphorylation of CtIP (show RBBP8 Proteins) and the epistatic and coordinated actions of MRE11 (show MRE11A Proteins) and CtIP (show RBBP8 Proteins) nuclease (show DCLRE1C Proteins) activities are required to limit the stable loading of Ku on single-ended DNA double-strand breaks.
these results suggest that polymorphisms of XRCC5 play an important role in astrocytoma prognosis in the Chinese Han population which could be used in the determination of astrocytoma prognosis in clinical researches
SAF-A (show HNRNPU Proteins), in concert with Ku, temporally regulates base damage repair in irradiated cell genome.
High XRCC5 expresiion is associated with medullary thyroid carcinoma.
Ku80 can be cleaved by caspases-2 at D726 upon a transient etoposide treatment. Caspase-2 (show CASP2 Proteins)-mediated Ku80 cleavage promotes Ku80/DNA-PKcs (show PRKDC Proteins) interaction as the D726A mutation diminished Ku80 interaction with DNA-PKcs (show PRKDC Proteins)
m-calpain translocated as the result of calcium influx was involved in DNA double-strand breaks repair, especially in the non-homologous end-joining pathway through proteolysis of nuclear Ku80. Cleaved Ku80 was still able to form a heterodimer with Ku70 and enhance DNA repair activity.
Ku80 CTR (show CALCR Proteins) (C-terminal region) is required for interaction with DNA-PKcs (show PRKDC Proteins) on short segments of blunt ended 25bp dsDNA or 25bp dsDNA with a 15-base poly dA ssDNA extension, but this requirement is less stringent on longer dsDNA molecules (35bp blunt ended dsDNA) or 25bp duplex DNA with either a 15-base poly dT or poly dC ssDNA extension. Moreover, DNA-PKcs (show PRKDC Proteins)-Ku complex forms on 25 bp DNA with poly-pyrimidine ssDNA extension.
Ku80 could predict the probability of resistance to neoadjuvant chemotherapy in lung adenocarcinoma, and reduced cisplatin and pemetrexed-induced apoptosis in A549 cells
results demonstrated that XRCC5 promoted colon cancer growth by cooperating with p300 (show EP300 Proteins) to regulate COX-2 expression, and suggested that the XRCC5/p300 (show EP300 Proteins)/COX-2 signaling pathway was a potential target in the treatment of colon cancers
Ku antigen displays the AP lyase (show APEX1 Proteins) activity on a certain type of double-stranded DNA.

Xenopus laevis X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5) interaction partners

VCP/p97 (show vcp Proteins) extracts sterically trapped Ku70 (show XRCC6 Proteins)/80 rings from DNA in double-strand break repair.
Double strand break (DSB)-induced ubiquitylation of Ku80 provides a mechanism to efficiently eliminate Ku from DNA for pre- and postrepair processes.

XRCC5 Protein Profile

Protein Summary

The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.

Alternative names and synonyms associated with XRCC5

X-ray repair cross complementing 5 (XRCC5)
X-ray repair complementing defective repair in Chinese hamster cells 5 (Xrcc5)
X-ray repair cross complementing 5 (Xrcc5)
X-ray repair complementing defective repair in Chinese hamster cells 5 L homeolog (xrcc5.L)

AI314015 protein
KARP-1 protein
KARP1 protein
KU80 protein
Ku86 protein
KUB2 protein
Kup80 protein
NFIV protein
XRCC5 protein
xrcc5-a protein

Protein level used designations for XRCC5

, , , , , , , , , , , , , , , , , , , , , , , , , , Ku autoantigen X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80kDa) X-ray repair protein X-ray repair cross-complementing protein 5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) ATP-dependent DNA helicase II ATP-dependent DNA helicase 2 subunit 2-like x-ray repair cross-complementing protein 5-like ATP-dependent DNA helicase 2 subunit 2 ATP-dependent DNA helicase II 80 kDa subunit CTC box-binding factor 85 kDa subunit CTC85 CTCBF DNA repair protein XRCC5 Ku p80 ku autoantigen protein p86 homolog nuclear factor IV Ku autoantigen, 80kD) X-ray repair cross complementation (double-strand-break rejoining X-ray repair cross complementation (double-strand-break rejoining; Ku autoantigen, 80kD) 86 kDa subunit of Ku antigen Ku autoantigen, 80kDa Ku86 autoantigen related protein 1 TLAA lupus Ku autoantigen protein p86 thyroid-lupus autoantigen X-ray repair complementing defective repair in Chinese hamster cells 5

GENE ID	SPECIES
449614	Pan troglodytes
478902	Canis lupus familiaris
574279	Macaca mulatta
100173343	Pongo abelii
100347656	Oryctolagus cuniculus
100409742	Callithrix jacchus
100484832	Ailuropoda melanoleuca
100514133	Sus scrofa
100603811	Nomascus leucogenys
22596	Mus musculus
363247	Rattus norvegicus
7520	Homo sapiens
394397	Xenopus laevis
424222	Gallus gallus
531945	Bos taurus

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