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anti-Rat (Rattus) FZR1 Antibodies:
anti-Human FZR1 Antibodies:
anti-Mouse (Murine) FZR1 Antibodies:
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Human Monoclonal FZR1 Primary Antibody for ELISA, WB - ABIN4273099
Yamamoto, Takano, Ishiwata, Ohmura, Nagahata, Matsuura, Kamata, Sakamoto, Nakanishi, Kubo, Hishiki, Suematsu: Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway. in Nature communications 2014
Human Polyclonal FZR1 Primary Antibody for ICC, IF - ABIN4312933
Fuchsberger, Martínez-Bellver, Giraldo, Teruel-Martí, Lloret, Viña: Aβ Induces Excitotoxicity Mediated by APC/C-Cdh1 Depletion That Can Be Prevented by Glutaminase Inhibition Promoting Neuronal Survival. in Scientific reports 2016
Human Polyclonal FZR1 Primary Antibody for ICC, IF - ABIN4312932
Giráldez, Galindo-Moreno, Limón-Mortés, Rivas, Herrero-Ruiz, Mora-Santos, Sáez, Japón, Tortolero, Romero: G1/S phase progression is regulated by PLK1 degradation through the CDK1/βTrCP axis. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017
Cow (Bovine) Polyclonal FZR1 Primary Antibody for WB - ABIN2784494
Hu, Li, Li, Tan, Wan, Zhu, Zhang, Zhang, Yao: Downregulation of Cdh1 signalling in spinal dorsal horn contributes to the maintenance of mechanical allodynia after nerve injury in rats. in Molecular pain 2016
porcine FZR1 and CDC20 (show CDC20 Antibodies) work on the maintenance of meiotic arrest at the first meiotic prophase and on the exit from M1
Data show that FZR1 (Fzr), a cofactor of the multi-subunit E3 ligase complex anaphase-promoting complex/cyclosome (APC (show APC Antibodies)/C), represents
CHD1 (show CHD1 Antibodies) loss is associated with an increased sensitivity to PARP (show COL11A2 Antibodies) inhibition and anti-cancer drugs that induce DNA intercross-strand links in prostate tumors.
APC (show APC Antibodies)/C and pRB (show RB1 Antibodies) interact with each other via the co-activator of APC (show APC Antibodies)/C, FZR1, providing an alternative pathway of regulation of G1 to S transition by pRB (show RB1 Antibodies) using a post-translational mechanism. Both pRB (show RB1 Antibodies) and FZR1 have complex roles and are implicated not only in regulation of cell proliferation but also in differentiation, quiescence, apoptosis, maintenance of chromosomal integrity and metabolism.
FZR1 inhibits BRAF (show BRAF Antibodies) oncogenic functions via both APC (show APC Antibodies)-dependent proteolysis and APC (show APC Antibodies)-independent disruption of BRAF (show BRAF Antibodies) dimers, whereas hyperactivated ERK (show EPHB2 Antibodies) and CDK4 (show CDK4 Antibodies) reciprocally suppress APC (show APC Antibodies)(FZR1) E3 ligase activity
These findings identify a dynamic interplay between FZR1 and BRAF (show BRAF Antibodies) with strong implications for cell-fate determination and the tumor suppressor role of FZR1
results suggest that reduction of FZR1 increases therapeutic sensitivity of B-ALL and that transient rather than tonic inhibition of FZR1 may be a therapeutic strategy.
results define a new APC (show APC Antibodies)/C(Cdh1 (show CDH1 Antibodies)) function that prevents cell cycle resumption after prolonged replication stress by inhibiting origin firing, which may act as an additional mechanism in safeguarding genome integrity.
APC (show APC Antibodies)(Cdh1 (show CDH1 Antibodies)) inactivation is the commitment point when cells lose the ability to return to quiescence and decide to progress through the cell cycle.
Data show that CDC20 (show CDC20 Antibodies) homolog 1 (Cdh1 (show CDH1 Antibodies)) is O-GlcNAcylated in cultured cells.
Cdh1 (show CDH1 Antibodies) contributes to spatiotemporal organization of AurB (show AURKB Antibodies) activity, and organization of FHOD1 (show FHOD1 Antibodies) activity by AurB (show AURKB Antibodies) contributes to daughter cell spreading after mitosis.
CHD1 (show CHD1 Antibodies) loss is associated with an increased sensitivity to PARP (show PARP1 Antibodies) inhibition and anti-cancer drugs that induce DNA intercross-strand links in prostate tumors.
loss of Cdh1 (show CDH1 Antibodies) leads to increased and extended S phase progression possibly due to the upregulation of cyclin D1 (show CCND1 Antibodies).
Both catalytic and non-catalytic APC (show APC Antibodies)/C-Fzr1/Cdh1-mediated activities of PTEN are required for stalk cells' proliferative arrest. Findings implicate the PTEN-APC (show APC Antibodies)/C-Fzr1/Cdh1 hub in angiogenesis.
Loss of APC (show APC Antibodies)/C(FZR1) activity in the male germline led to both a mitotic and a meiotic testicular defect resulting in infertility due to the absence of mature spermatozoa.
Fzr1 is a surprisingly essential gene involved in the establishment of a single spindle from the two pronuclei in 1-cell embryos as well as being involved in the maintenance of genomic integrity during the mitotic divisions of early mammalian embryos.
This study implicates FZR1 as a major regulator of prometaphase whose activity helps to prevent chromosome nondisjunction.
When a neuronal cell enters S phase, Cdk5 (show CDK5 Antibodies) is transported to the cytoplasm where it is ubiquitinated by the E3 ligase APC (show APC Antibodies)-Cdh1 (show CDH1 Antibodies)
Cdh1 (show CDH1 Antibodies)-APC (show APC Antibodies) appears to play a role in regulating axonal growth and patterning in the developing brain that may also limit the growth of injured axons in the adult brain.
FZR1 activity is required to repress cyclin B1 (show CCNB1 Antibodies) levels in oocytes during prophase I arrest in the ovary, thereby maintaining meiotic quiescence until hormonal cues trigger resumption
Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage leads to the ubiquitination of PLK1, preventing entry into mitosis (By similarity).
fizzy-related protein homolog
, fizzy/cell division cycle 20 related 1 (Drosophila)
, fizzy-related protein FZR
, Fizzy-related protein-like protein
, fizzy/cell division cycle 20 related 1
, CDC20-like 1b
, CDC20-like protein 1
, cdh1/Hct1 homolog
, cell division cycle 20 related 1