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FZR1 antibody (AA 1-496)
FZR1
Reactivity: Human
WB
Host: Mouse
Monoclonal
1621CT637-76-67
unconjugated
Product Details anti-FZR1 Antibody
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Target
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FZR1
(Fizzy/cell Division Cycle 20 Related 1 (FZR1))
Binding Specificity
All epitopes for FZR1 antibodies
AA 1-496
Reactivity
All reactivities for FZR1 antibodies
Human
Host
All hosts for FZR1 antibodies
Mouse
Clonality
All clonalities for FZR1 antibodies
Monoclonal
Conjugate
All conjugates for FZR1 antibodies
This FZR1 antibody is un-conjugated
Application
All applications for FZR1 antibodies
Western Blotting (WB)
Purification
This antibody is purified through a protein G column, followed by dialysis against PBS.
Immunogen
This FZR antibody is generated from a mouse immunized with a recombinant protein between1-496 amino acids from human FZR.
Clone
1621CT637-76-67
Isotype
IgG1 kappa
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Alternatives
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Application Details
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Application Notes
WB: 1:2000
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Expiry Date
6 months
Target Details for FZR1
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Target
FZR1
(Fizzy/cell Division Cycle 20 Related 1 (FZR1))
Alternative Name
FZR (FZR1 Products )
Synonyms
CDH1-C antibody, FYR antibody, FZR antibody, CDH1 antibody, fzr1 antibody, CDC20C antibody, FZR2 antibody, HCDH antibody, HCDH1 antibody, AW108046 antibody, Cdh1 antibody, Fyr antibody, zgc:55450 antibody, fizzy and cell division cycle 20 related 1 antibody, fizzy/cell division cycle 20 related 1 antibody, fizzy-related protein homolog antibody, fizzy/cell division cycle 20 related 1 (Drosophila) antibody, fizzy/cell division cycle 20 related 1a antibody, Fzr1 antibody, CDH1-C antibody, FZR1 antibody, LOC100027495 antibody, LOC100179951 antibody, fzr1a antibody
Background
Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.
Molecular Weight
55179
UniProt
Q9UM11
Pathways
DNA Replication , Synthesis of DNA
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