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increased expression of ALDH1A1-RDH10-RARalpha- PPARbeta/delta pattern could be considered as adverse prognostic factor associated with a higher concentration of paraprotein and worst overall survival of patients with newly diagnosed multiple myeloma.
research, verifies the significance of the ALDH1A isoforms in multidrug resistance of human colorectal cancer cells and its potential as a cancer stem cell marker
ALDH expression in decidual mesenchymal stem cells is required for cellular resistance to oxidative stress.
NGFR and ALDH1A1+ cells are lost during tumourigenesis
These data revealed crucial roles of ALDH(-) cancer stem cell in Papillary thyroid carcinoma biology and suggested that cancer stem cell subpopulations function cooperatively to control Papillary thyroid carcinoma initiation and progression.
ALDH1 and tumor infiltrating lymphocytes as predictors for neoadjuvant chemotherapy response in breast cancer
the expression of the ALDH1A1 protein in colorectal cancer (CRC) tissues was significantly associated with the presence of lymph node metastases and might be a potential prognostic marker in patients with CRC.
High ALDH1A1 expression may be a prognostic indicator of survival in patients with gastric neuroendocrine carcinoma
In this review, we elevated the role of ALDH to be a potential marker to define and distinguish hematopoietic stem cells and leukemia stem cells and its importance in prognosis and target therapy in AML patients
Quercetin suppressed breast cancer stem cell proliferation, self-renewal, and invasiveness. It also lowered the expression levels of proteins related to tumorigenesis and cancer progression, such as aldehyde dehydrogenase 1A1, C-X-C chemokine receptor type 4, mucin 1, and epithelial cell adhesion molecules.
Basing on the available evidence, this meta-analysis showed that high levels of ALDH1 expression correlate with worse OS and PFS in ovarian cancer patients.
Data suggested that ALDH1A1 may be an independent prognostic indicator and a new molecular biomarker for diagnosis in B-cell non-Hodgkin's lymphoma.
findings suggested that ALDH1 played an important role in treatment response and the tumor-promoting microenvironment in OSCC
NFATc2 enhances tumor-initiating phenotypes through the NFATc2/SOX2/ ALDH1A1 axis in lung adenocarcinoma.
significant association between ALDH1A1 expressions with Gleason score indicates the potential role of this protein in PCa tumorigenesis and aggressive behavior; therefore, this cancer stem cell marker can be used as a promising candidate for targeted therapy of PCa, especially those with high Gleason score
this study identified TAZ as a novel inducer of lung cancer stem cells and the first transcriptional activator of the stem cell marker ALDH1A1
these findings indicate that ALDH1 can be prognosis prediction markers for urinary tract carcinomas
Circulating tumor cells expressing cytokeratin and tumor-initiating cell markers, including ALDH, CD133, and CD44, were identified in patients with pancreatic adenocarcinoma. These TIC-like CTCs were associated with poor prognosis after surgical resection and with an increased incidence of tumor recurrence
approximately 25% of all acute myeloid leukemias expressed low or undetectable levels of ALDH1A1 and this ALDH1A1(-) subset of leukemias correlates with good prognosis cytogenetics
These findings suggest that ALDH1 expression in malignant melanoma has a favorable effect on patient survival
analysis of bioactivation of nitroglycerin by purified mitochondrial and cytosolic aldehyde dehydrogenases ALDH1 and ALDH2
Data indicate involvement of non-POU domain-containing octamer-binding protein (NONO)/paraspeckle protein component 1 (PSPC1)-aldehyde dehydrogenase 1 (NONO/PSPC1-ALDH1A1) in the modulation of Sertoli cells (SCs) response to mono-(2-ethylhexyl) phthalate (MEHP) challenge.
In ovaries lacking ALDH1A1, the onset of germ cell meiosis is delayed.
Dioxin receptor regulates aldehyde dehydrogenase to block melanoma tumorigenesis and metastasis
these experiments reveal an evolutionarily conserved GABA synthesis pathway mediated by aldehyde dehydrogenase 1a1 (ALDH1a1).
Respiratory tract epithelial cells express retinaldehyde dehydrogenase ALDH1A and enhance IgA production by stimulated B cells in the presence of vitamin A.
Dkk-1 enhances resistance of osteosarcoma cells to stress by tipping balance of Wnt signaling in favor of the non-canonical Jun-mediated Wnt pathways. In turn, this results in transcriptional activation of ALDH1 through Jun-responsive promoter elements.
Deletion of Aldh1a1 exacerbated alpha-synuclein-mediated DA neurodegeneration and alpha-synuclein aggregation, whereas Aldh1a1-null and control DA neurons were comparably susceptible to 1-methyl-4-phenylpyridinium-, glutamate-, or camptothecin-induced cell death.
Our findings indicated that increased expression of ALDH1A1 in nasopharyngeal carcinoma was associated with enhanced invasiveness in the nude mouse.
PSMB8, ALDH1A1, and HSPA4 were identified to be located in ovarian tissues, to regulate 12 cellular pathways, and demonstrate age-dependent dynamic changes in expression profiling.
beta-escin inhibits tobacco carcinogen-induced lung tumor formation by modulating ALDH1A1-positive cells and RhoA/Rock signaling
ALDH1A1 deficiency induces BMP2 and increases bone mass in vivo.
retinoic acid-producing enzyme aldehyde dehydrogenase 1a1 (Aldh1a1) is an oncogene suppressor in specific B cell populations.
Expression of ALDH1A1 isozyme transcripts was highest in ALDH(very-br) cells, intermediate in ALDH(br) cells, and lowest in ALDH(dim) cells.
high fat diet mediates visceral fat formation through a sex-specific autocrine Aldh1 switch.
Retinaldehyde dehydrogenase 1 coordinates hepatic gluconeogenesis and lipid metabolism
analysis of neurodegeneration and motor dysfunction in mice lacking cytosolic and mitochondrial aldehyde dehydrogenases
This result demonstrates the critical role of stress resistance in myogenic cell therapy as well as confirms the role of ALDH as a marker for rapid isolation of murine and human myogenic progenitors for cell therapy.
data establish Aldh1a1 and its substrate Rald as previously unrecognized determinants of adipocyte plasticity and adaptive thermogenesis, which may have potential therapeutic implications
ALDH1A1 deficiency increases ALDH3A1 expression. Mice deficient in both ALDH3A1 & ALDH1A1 have fewer HSCs, aberrant cell-cycle distribution, increased reactive oxygen species, p38 MAP kinase activity & sensitivity to DNA damage.
expression can be detected in canals of Hering and bile duct epithelial cells and is increased on liver injury
The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet.
ALDH class 1
, RALDH 1
, acetaldehyde dehydrogenase 1
, aldehyde dehydrogenase 1, soluble
, aldehyde dehydrogenase, liver cytosolic
, retinal dehydrogenase 1
, retinaldehyde dehydrogenase 1
, aldehyde dehydrogenase 1A1
, aldehyde dehydrogenase family 1 member A1
, aldehyde dehydrogenase, cytosolic
, cytosolic aldehyde dehydrogenase
, chromosome 1 GSS clone AHT1-34
, aldehyde dehydrogenase 1 family, member A1
, aldehyde dehydrogenase 1, subfamily A1
, aldehyde dehydrogenase 2
, aldehyde dehydrogenase family 1, member A1
, aldehyde dehydrogenase family 1, subfamily A1
, aldehyde dehydrogenase class 1
, retinal dehydrogenase 1-like
, alcohol dehydrogenase family 1, subfamily A1
, alcohol dehydrogenase family 1, subfamily A2
, aldehyde dehydrogenase 1, liver cytosolic (class 1)
, aldehyde dehydrogenase
, Aldehyde dehydrogenase family 1 member A1
, Aldehyde dehydrogenase, cytosolic