Protein Summary

This gene encodes a member of the bicoid subfamily of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and plays a role in brain, craniofacial, and sensory organ development. The encoded protein also influences the proliferation and differentiation of dopaminergic neuronal progenitor cells during mitosis. Mutations in this gene cause syndromic microphthalmia 5 (MCOPS5) and combined pituitary hormone deficiency 6 (CPHD6). This gene is also suspected of having an oncogenic role in medulloblastoma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Pseudogenes of this gene are known to exist on chromosomes two and nine.

Alternative names and synonyms associated with Orthodenticle Homeobox 2 (OTX2)

• orthodenticle homeobox 2 (OTX2) antibody
• orthodenticle homeobox 2 (Otx2) antibody
• orthodenticle homeobox 2 S homeolog (otx2.S) antibody
• orthodenticle homeobox 2 (otx2) antibody

• CPHD6 antibody
• E130306E05Rik antibody
• id:ibd2915 antibody
• MCOPS5 antibody
• otx-2 antibody
• Show all synonym aliases
• otx2 antibody
• Xotx-2 antibody
• Xotx2 antibody
• zgc:136535 antibody
• zotx-2 antibody
• zOtx2 antibody

Protein level used designations for OTX2

homeobox protein OTX2 , orthodenticle homolog 2 , orthodenticle homeobox protein 2 , homeobox Otx2 , homeobox protein OTX2-A , orthodenticle 2-A , orthodenticle-A-like protein A , xOTX2-A , etID309955.17