No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Select your origin of interest
DNA of the impulsive but not the calm subjects was methylated at one DAT SNP.
nitrative damage accumulates in midbrain neurons with age; The capacity of a dopamine neuron to accumulate more cytosolic DA, as inferred from DA transporter expression, is related to accumulation of nitrative damage
Two C-terminal motifs dictate synaptic localization of DAT-1.
Endogenous dopamine actions in C. elegans are tightly regulated by synaptic DAT-1.
loss of UNC-64/DAT-1 interactions leads to enhanced synaptic dopamine release
T23G5.5-transfected HeLa transports dopamine. Weaker activity for other biogenic amines (tyramine, octopamine, serotonin, norepinephrine). Inhibitors include the tricyclics imipramine and desipramine, cocaine, nomifensine, nisoxetine, and D-amphetamine.
Dopamine transporter plays an important role in controlling ethanol intake and nucleus accumbens dopamine transporter contributes to reinforcing effects of ethanol.
DAT knockdown in the nucleus accumbens, but not in the caudate putamen, improve anxiety- and depression-like symptoms in adult mice and the data illustrate the complex way DAT contributes to emotional behavior.
snapin/DAT interaction represents a direct link between exocytotic and reuptake mechanisms.
PREP regulates the function of dopamine transporter, possibly by controlling the phosphorylation and transport of dopamine transporter into the striatum or synaptic membrane.
Melatonin MT1 and MT2 receptors interact with dopamine transporter (DAT) in striatum.
Study generated a transgenic rat model that overexpresses the mouse DAT gene via pronuclear microinjection. These rats specifically exhibited behavioral and pharmaco-therapeutic phenotype of repetitive disorders. Together, findings suggest that the DAT rat model will constitute a valuable tool for studying the pathological role of DAT overexpression on neural systems relevant to relevant to neuropsychiatric disorders.
The findings of thuis study indicated that the DAT Val559 variant induces impulsivity behaviors that are dependent upon the reward context, with increased impulsive action observed when mice are required to delay responding for a reward.
These results suggest that DAT expression affects TH expression and phosphorylation largely in DA terminal field compartments.
These behavioral and molecular phenotypes indicate that a genetic-driven DAT hypofunction alters neurodevelopmental trajectories consistent with ADHD, but not with schizophrenia and bipolar disorders.
An exquisite microanatomical regulation of dopamine by the dopamine transporter was identified in striosomes relative to the matrix in the corpus striatum.
Data suggest that environment pollutants methylmercury and 1-methyl-4-phenylpyridinium decrease release of dopamine from dopaminergic neurons; this mechanism involves down-regulation of expression of Slc6a3.
This study show that Dopamine transporter is enriched in filopodia and induces filopodia formation.
The sigma-1R deficiency through suppressing NR2B function and DAT expression can reduce MPTP-induced death of dopaminergic neurons and parkinsonism.
DAT gene knockout in mice results dendritic spine loss in pyramidal neurons in the CA1 field of the hippocampus.
Results show that moderate increases in DAT function cause spontaneous dopaminergic cell loss, oxidative stress and fine motor impairment that is reversed by l-DOPA treatment
Chronic and acute reductions of DAT functioning in mice impaired decision-making.
These results demonstrate that the presence of the N-terminal tag leads to impaired DAT protein expression in vivo due in part to improper trafficking of the tagged transporter.
studies demonstrate an in vivo functional impact of the DAT Val559 variant, providing support for the ability of DAT dysfunction to impact risk for mental illness.
The data of this study imply that individual differences in DAT expression (either genetically or pharmacologically induced) may affect susceptibility to addiction of different types of psychostimulants.
findings support the idea that altered DAT and VMAT2 expression affect age-related changes in dopaminergic function.
DAT-mediated dopamine uptake plays a role in the absorption and distribution of dopamine following intranasal administration
Study found individual differences in reinforcement learning behavior were related to DAT binding potential in ventral striatum and resting-state functional connectivity between ventral striatum and orbitofrontal cortex.
Findings suggest that peripheral DAT1 promoter methylation may be predictive of striatal DAT availability in adults with attention-deficit hyperactivity disorder.
Dopamine transporter forms stable dimers in the live cell plasma membrane in a phosphatidylinositol 4,5-bisphosphate-independent manner.
The results reveal that patients homozygous for the 10-repeat DAT1allele showed significantly greater thickness in right cingulate gyrus and right BA 24 compared with 9-repeat carriers. Conclusion: These findings suggest that thickness of cingulate cortex is influenced by the presence of the 10-repeat dat1 allele in ADHD.
results do not support an association of the analysed SLC6A3 and MBP gene polymorphisms with PTSD in war traumatized individuals; there is a possibility for a correlation of the T allele rs12458282 within the MBP gene with higher CAPS scores in lifetime PTSD patients which would need to be tested in a sample providing more statistical power
In women, there was an association between the DAT1 polymorphism and childhood experiences of emotional abuse, such that women with the 9R9R genotype reported less emotional abuse experiences than women with the 9R10R or 10R10R genotypes. No other associations between the DAT1 polymorphism and childhood experiences of abuse and neglect were found. In sum, the results suggested that some genetic components might predispose
these results reveal a multimodal regulatory mechanism in SLC6A3.
This is the first study analyzing the affective temperament in an obese population in the context of dopaminergic genes polymorphisms, including COMT Val158Met, DRD4, and DAT1. The results of our study indicate the connection between the irritable and cyclothymic dimensions in COMT heterozygotes only.
DAT1-related GMV alterations in the posterior cortical regions may contribute to visual memory performance in children with ADHD.
Genetic variations in SLC6A3 are not associated with smoking cessation.
The SLC6A3 intron 8 VNTR polymorphism and the combinatorial effect can modulate the time estimate in the domain of supra seconds.
Dephosphorylation of human dopamine transporter at threonine 48 by protein phosphatase PP1/2A up-regulates transport velocity.
t is defined by a "half-open and inward-facing" state (HOIF) of the intracellular gate that is stabilized by a network of interactions conserved phylogenetically, as we demonstrated in hDAT by Rosetta molecular modeling and fine-grained simulations, as well as in its bacterial homolog leucine transporter by electron paramagnetic resonance analysis and X-ray crystallography.
Data demonstrate that dopamine transporter (DAT) availability in ventral striatum (VS) is negatively related to impulsivity and suggest a particular influence of DAT regulation of dopamine signaling in VS.
Polymorphisms near or within key genes regulating dopaminergic synapse, including SLC6A3, have been associated with altered reward circuitry responsivity related to a spectrum of Addictive Behaviors.
Genetic variations in SLC6A3 and DRD2 may play an important role in pain expression among the elderly prior to orthopedic surgery
Two months of OROS-MPH treatment decreased DAT availability in both the right caudate and putamen. Adolescents with ADHD who showed a robust response to OROS-MPH had greater reduction of DAT density in the right putamen. However,our findings did not support an association between homozygosity for a 10-repeat allele in the DAT1 gene and DAT density, assessedusing[Tc-99m] TRODAT-1SPECT.
DAT1 9R carriers have more traffic accidents than 10R homozygotes.
results of study show that there is no difference in l-dopa induced dyskinesias prevalence among carriers of the two DAT gene polymorphisms.
(AZI2)3'UTR confers variant-dependent transcriptional regulation of SLC6A3, a potential risk factor for substance abuse disorders.
This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence.
dopamine transporter variant II
, sodium-dependent dopamine transporter
, solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
, sodium-dependent dopamine transporter-like
, DA transporter
, dopamine transporter 1
, solute carrier family 6 member 3
, solute carrier family 6, member 3