Browse our anti-VSX2 (VSX2) Antibodies

Human Visual System Homeobox 2 (VSX2) interaction partners

1. In conclusion, targeted sequencing for SOX2 (show SOX2 Antibodies) and VSX2 identified the etiology in two patients (7.4%) and this is the first report of SOX2 (show SOX2 Antibodies) mutation from Egypt.

2. Regulation of WNT (show WNT2 Antibodies) signaling by VSX2 during optic vesicle patterning in human induced pluripotent stem cells has been described.

3. The phenotype of this girl is unique and suggests a normal regulatory role for VSX2 in iris, zonule, and cone-rod development.

4. The role of visual system homeobox 2 (VSX2), using human induced pluripotent stem cells derived from a patient with microphthalmia caused by an R200Q mutation in the VSX2 homeodomain region, is reported.

5. Mutations in VSX2 represent an important cause of autosomal recessive microphthalmia in consanguineous pedigrees.

6. study identified 3 recessive VSX2 mutations associated with isolated congenital anophthalmia or severe microphthalmia; also identified a novel inner retinal dystrophy (show MERTK Antibodies) in 2 carrier parents suggesting a semidominant effect for this particular VSX2 mutation

7. major differentiation factors of the NK-cell lineage, including HOXA9, HOXA10 and ID2, were (de)regulated via PRC2 which therefore contributes to T-cell leukemogenesis.

8. CHX10 regulates RdCVF (show NXNL1 Antibodies) promoter activity in the inner retina.

9. CHX10 and VSX1 (show VSX1 Antibodies) may control retinal bipolar cell specification or differentiation by repressing genes required for the development of other cell types

10. CHX10 may target specific motifs to inhibit rod photoreceptor gene expression in bipolar cells

Mouse (Murine) Visual System Homeobox 2 (VSX2) interaction partners

1. Vsx2 represses Mitf (show MITF Antibodies) in a cell-autonomous way. It also uses cell-nonautonomous mechanisms to regulate progenitor properties in the embryonic retina. Vsx2's role in regulating Mitf (show MITF Antibodies) is in part separable from its role in promoting proliferation.

2. The results of this study suggested that Lhx3/Chx10 medullary reticular formation neurons are involved in locomotion.

3. Our data suggest that the phenotypic severity of the CVC mutant depends on the weakened DNA binding activity elicited by the CVC mutation and a previously unknown protein interaction between Vsx2 and its regulatory target Mitf (show MITF Antibodies).

4. analysis of the regulatory role of a conserved motif adjacent to the homeodomain of Hox10 proteins

5. Reducing GDF11 (show GDF11 Antibodies) levels might promote restoration of retinal development in the microophthalmic Vsx2 mutant mouse.

6. Data demonstrate that Hox10 genes play a critical role in the developing kidney.

7. Blimp1 may play a role in photoreceptor development by repressing genes involved in bipolar cell fate specification and retinal cell proliferation in differentiating precursors; Blimp1 can bind to the Chx10 enhancer and repress Chx10 enhancer activity

8. CHX10 regulates RdCVF (show NXNL1 Antibodies) promoter activity in the inner retina.

9. Genetic rescue of cell number in a mouse model of microphthalmia: interactions between Chx10 and G1-phase cell cycle regulator p27(Kip1 (show CDKN1B Antibodies)).

10. results have shown that the Hox10 and Hox11 (show TLX1 Antibodies) paralogous genes are global regulators of the lumbosacral region of the axial skeleton and are integral in patterning principal limb elements

Zebrafish Visual System Homeobox 2 (VSX2) interaction partners

1. These data support a model by which vsx2, operating through the effector gene opo, acts as a central transcriptional node that coordinates neural retina patterning and optic cup invagination in zebrafish.

2. Mutual antagonism of the paired-type homeobox (show PRRX1 Antibodies) genes, vsx2 and dmbx1, regulates retinal progenitor cell cycle exit upstream of ccnd1 (show CCND1 Antibodies) expression.

3. Vsx2-positive RPCs are fully multipotent retinal progenitors and that when Vsx2 is downregulated, Vsx2-negative progenitors escape Vsx2 repression and so are able to express factors that restrict lineage potential.