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Adcy4 deficiency is a hallmark of the forskolin-resistant phenotype of the adrenocortical tumor mutants studied and Adcy4 is an important target of forskolin action in the Y1 adrenal cell line.
SF1 (show SF1 Proteins) and SP1 (show SP1 Proteins) contribute to Adcy4 promoter activity via interation with conserved region situated 19 bp upstream of the major transcription start site.
AC4 and AC2, both isoforms stimulated by Gbetagamma, are expressed in bronchial nonlipid raft membrane fractions where they colocalize with and couple to prostanoid EP2 (show SPAG11B Proteins) receptors.
The HIV-1 regulatory protein Tat (show TAT Proteins) was shown to inhibit the activity of adenylyl cyclase in rat microglial cells.
This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylate cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals. Alternative splicing results in transcript variants.
adenylate cyclase 4
, adenylate cyclase type 4-like
, ATP pyrophosphate-lyase 4
, adenylate cyclase type 4
, adenylate cyclase type IV
, adenylyl cyclase 4