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anti-Human Adenosine a1 Receptor Antibodies:
anti-Mouse (Murine) Adenosine a1 Receptor Antibodies:
anti-Rat (Rattus) Adenosine a1 Receptor Antibodies:
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Human Polyclonal Adenosine a1 Receptor Primary Antibody for WB - ABIN611319
Bowery, Brown: The cloning of GABA(B) receptors. in Nature 1997
Show all 3 Pubmed References
Human Polyclonal Adenosine a1 Receptor Primary Antibody for IF (p), IHC (p) - ABIN719396
Cao, Dai, Wei, Han, Guan, Li, Liu, Xiao, Li: Effects of cordycepin on spontaneous alternation behavior and adenosine receptors expression in hippocampus. in Physiology & behavior 2017
Cow (Bovine) Polyclonal Adenosine a1 Receptor Primary Antibody for ELISA - ABIN314251
Funakoshi, Chan, Good, Libonati, Piuhola, Chen, MacDonnell, Lee, Herrmann, Zhang, Martini, Palmer, Sanbe, Robbins, Houser, Koch, Feldman: Regulated overexpression of the A1-adenosine receptor in mice results in adverse but reversible changes in cardiac morphology and function. in Circulation 2006
Data suggest that activation of adenosine A1 receptors elicit receptor-operated Ca(2+) entry in porcine afferent arterioles, the level of which is dependent on postnatal maturation of TRPC3 channels.
mRNA for adenosine A(1), A(2A), A(2B (show ADRA2B Antibodies)), and A(3) receptors was expressed in arterioles and venules. Protein for A(1), A(2A), and A(2B (show ADRA2B Antibodies)), but not A(3), was detected in both microvessel types and was further demonstrated on vascular endothelial cells
ADORA1 is not a common risk factor or causal gene for Parkinson's disease or dementia with Lewy bodies in the European population
monocyte-derived macrophages from ankylosing spondylitis patients expressed increased levels of A2AAR (show ADORA2A Antibodies) and reduced levels of A1 and A2BAR (show ADORA2B Antibodies) compared to healthy controls
studies revealed individual trait characteristics for being either vulnerable or resilient to both alcohol and to sleep deprivation. Both interventions induce gradual increases in cerebral A1AR availability, pointing to a potential common molecular response mechanism.
Data suggested that adenosine A1 receptor might potentiate glycinergic transmission through Galphai/PKA/alpha3 and Gbetagamma/alpha1ins pathways in inflamed rat.
Elevated A1 adenosine receptor is associated with sleep deprivation.
Mutation in ADORA1 may be associated with early-onset parkinsonism and cognitive dysfunction.
This study showed that increased neuronal A1R expression in Rasmussen Encephalitis may be involved in prevention of seizures spread and seizures-induced damage, limitation of both seizures and inflammation atrophy in 1 cerebral hemisphere.
A1R signaling enhances A2AR (show ADORA2A Antibodies)-mediated neurodegeneration [review]
Mutational and computational analysis of A1-AR revealed a distinct conformation of the second extracellular loop and a wider extracellular cavity with a secondary binding pocket that can accommodate orthosteric and allosteric ligands.
this study highlights a key role for extracellular loop 2 in A1AR orthosteric ligand binding and receptor activation.
Loss of A1AR expression results in an increased susceptibility to noise-induced cochlear neural injury and hearing loss.
Expression of the SENP2 (show SENP2 Antibodies) gene was suppressed by theobromine. In vivo knockdown studies showed that AR1 (show TCF20 Antibodies) knockdown in mice attenuated the anti-adipogenic effects of theobromine in younger mice. Theobromine suppresses adipocyte differentiation and induced C/EBPbeta (show CEBPB Antibodies) degradation by increasing its sumoylation.
The three receptor sets considered (mAChR (show CHRM3 Antibodies), AR and TrkB (show NTRK2 Antibodies) receptors) intervene in modulating the conditions of the competition between nerve endings.
Systemic inflammatory response syndrome-associated lymphopenia is initiated by A1R desensitization and adenosine-mediated inhibition of IL-15 (show IL15 Antibodies) production is part of the mechanism that accounts for the delay in leukopenia recovery in patients with severe sepsis.
Results demonstrated a significant downregulation of adenosine A1 receptors in the cortex and striatum, concomitant to striatal D2R (show DRD2 Antibodies) downregulation in iron deficient mice and rats.
Adenosine A1A receptor and adenosine A3A receptor agonists and adenosine 5'-monophosphate cause regulated hypothermia that was characterized by a drop in total energy expenditure, physical inactivity, and preference for cooler environmental temperatures, indicating a reduced body temperature set point.
over-expression of sEH (show EPHX2 Antibodies) enhances A1AR-dependent contraction and reduces KATP channel-dependent relaxation in MAs (show MAS1 Antibodies). These results suggest a possible interaction between sEH (show EPHX2 Antibodies), A1AR, and KATP channels in regulating vascular tone.
Results indicate that the adenosine A1 receptor is an important molecular component mediating hypoxic depression in adult mice and it appears to stabilize respiration of neonatal mice
The findings of this study implicated a glial-neuronal circuit, mediated by Ado (show ADO Antibodies), neuronal AdoRA1, and glial AdK (show ADK Antibodies) that can modulate sleep homeostasis in a manner influenced by glial metabolic state.
Adenosine A1 receptor knockout mice displayed increased depressive-like behavior.
Data suggest that that ADORA1 forms homomers/homodimers in brain cortex.
Adenosine A1 receptors promote vasa vasorum endothelial cell barrier integrity via Gi and Akt-dependent actin cytoskeleton remodeling.
The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene.
adenosine A1 receptor
, A1 adenosine receptor
, adenosine receptor A1