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The authors herein prove, for the first time, that the transcriptional repressor Blimp1 (show PRDM1 Proteins) is a novel mediator of p130Cas/ErbB2 (show ERBB2 Proteins)-mediated invasiveness. Indeed, high Blimp1 (show PRDM1 Proteins) expression levels are detected in invasive p130Cas/ErbB2 (show ERBB2 Proteins) cells and correlate with metastatic status in human breast cancer patients.
the results of our study identify BCAR1 as a prognostic biomarker with potential clinical value for risk stratification of ERG (show ERG Proteins)-negative prostate cancer.
Silencing of p130Cas and inhibition of FAK (show PTK2 Proteins) activity both strongly reduced imatinib and nilotinib stimulated invasion.
the p130Cas FAT domain uniquely confers a mechanosensing function.
Tyrosine phosphorylation of focal adhesion kinase (FAK) and p130 (show RBL2 Proteins) Crk-associated substrate (CAS) was found to be correlated with pancreatic cancer cell invasiveness.
Full-length and truncated p130Cas phosphorylated substrate domain molecules were expressed in breast cancer cells. Breast cancer cells expressing the full-length SD and the functional smaller SD fragment (spanning SD motifs 6-10) were injected into the mammary fat pads of mice. Both the complete and truncated SD significantly increased the occurrence of metastases to multiple organs.
Elevated levels of p130Cas is associated with trastuzumab resistance in breast cancer.
blockade of GD3-mediated growth signaling pathways by siRNAs might be a novel and promising therapeutic strategy against malignant melanomas, provided signaling molecules such as p130Cas and paxillin (show PXN Proteins) are significantly expressed in individual cases.
expression quantitative trait loci studies implicate BCAR1 as the causal gene of coronary artery disease Carotid intima-media thickness
p130(Cas) exon 1 variants display altered functional properties; shorter 1B isoform exhibited diminished FAK (show PTK2 Proteins) binding activity + reduced cell migration + invasion; longest variant 1B1 exhibited the most efficient FAK (show PTK2 Proteins) binding + greatly enhanced migration
Data suggest that the first LD motif (LD1; leucine-rich motif) of paxillin (show PXN Proteins) binds to the CCHD (C-terminal region of Cas (show CTNND1 Proteins) family homology domain) of p130Cas/Bcar1 (in a 1:1 stoichiometry with Kd approximately 4.2 uM); p130Cas/Bcar1 CCHD is stabilized by forming complex with paxillin (show PXN Proteins) LD1; these studies utilized chicken paxillin (show PXN Proteins) and mouse p130Cas/Bcar1. (p130Cas/Bcar1 = breast cancer anti-estrogen resistance protein 1)
reduction of p130Cas levels by siRNA affects process outgrowth, the thickness of cellular processes and migration behavior of Oli (show TOMM22 Proteins)-neu cells. long term p130Cas reduction results in increased apoptosis in cultured primary oligodendrocytes.
CRP2 (show CEBPB Proteins) sequesters p130Cas at focal adhesions, thereby reducing lamellipodia formation and blunting vascular smooth muscle cell migration.
p130Cas plays pivotal roles in osteoclastic bone resorption.
31-kDa caspase (show CASP3 Proteins)-generated cleavage product of p130Cas inhibited MyoD (show MYOD1 Proteins)-induced transcriptional activation of muscle-specific (show EIF3K Proteins) genes.
beta1-Integrin signaling within migrating ganglion cell layer cells requires Cas (show CTNND1 Proteins) signaling-adaptor proteins
Crk-associated substrate -vinculin (show VCL Proteins) binding significantly affects the dynamics of Crk-associated substrate and vinculin (show VCL Proteins) within focal adhesions as well as the size of focal adhesions.
we provide evidence that exercise-induced p38 MAPK (show MAPK14 Proteins) signaling is not impaired by the muscle-specific (show EIF3K Proteins) deletion of p130Cas. We conclude that p130Cas plays a limited role in mechanical-stress-induced skeletal muscle adaptation.
study described a molecular complex of PTPalpha (show PTPRA Proteins)-BCAR3 (show BCAR3 Proteins)-Cas (show CTNND1 Proteins)-Src (show SRC Proteins); this complex forms in response to PTPalpha (show PTPRA Proteins) Tyr789 phosphorylation and mediates Cas (show CTNND1 Proteins) localization to focal adhesions and Cas (show CTNND1 Proteins) downstream signaling to promote cell migration
p130Cas phosphorylation, mediated by integrin beta3, facilitates cofilin inactivation and promotes myogenic differentiation through modulating actin cytoskeleton remodelling
bcar3 gene is expressed downstream of Gata2 (show GATA2 Proteins) during gastrulation, and is co-expressed with gata2 (show GATA2 Proteins) but is more broadly expressed during later development; its binding partner, bcar1 shows overlapping expression patterns
BCAR1, or CAS, is an Src (MIM 190090) family kinase substrate involved in various cellular events, including migration, survival, transformation, and invasion (Sawada et al., 2006
Cas scaffolding protein family member 1
, Crk-associated substrate p130Cas
, breast cancer anti-estrogen resistance protein 1
, CRK-associated substrate
, p130 Cas
, v-crk-associated tyrosine kinase substrate
, breast cancer anti-estrogen resistance 1
, breast cancer anti-estrogen resistance protein 1-like