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Full name:: Calcium/calmodulin-Dependent Protein Kinase IV Proteins (CAMK4)

On www.antibodies-online.com are 17 Calcium/calmodulin-Dependent Protein Kinase IV (CAMK4) Proteins from 9 different suppliers available. Additionally we are shipping CAMK4 Antibodies (165) and CAMK4 Kits (4) and many more products for this protein. A total of 202 CAMK4 products are currently listed.

Synonyms:: A430110E23Rik, AI666733, caMK, CaMK-GR, CAMK4, camk4-A, CaMK IV, CaMKIV, CaMKIV/Gr, Ccdpk, D18Bwg0362e, IV, RATCCDPK, wu:fj42a03, zgc:110275

list all proteins	Gene Name	GeneID	UniProt
	CAMK4	814	Q16566
	CAMK4	12326
	CAMK4	25050	P13234
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Human Calcium/calmodulin-Dependent Protein Kinase IV (CAMK4) interaction partners

vanillin binds strongly to the active site cavity of CAMKIV and stabilized by a large number of non-covalent interactions.
Genotype and allele frequencies of CAMKIV gene SNPs differed significantly between alcohol dependence patients and control subjects. The results of the present study suggest that CAMKIV might be a candidate alcohol dependence gene.
hTau accumulation impairs synapse and memory by CaN-mediated suppression of nuclear CaMKIV/CREB (show CREB1 Proteins) signaling.
Within the pH range 5.0-11.5, CAMK4 maintained both its secondary and tertiary structures, along with its function, whereas significant aggregation was observed at acidic pH (2.0-4.5).
A positive association was not observed between rs10491334 in the CAMK4 gene and longevity in a Chinese population.
The T-allele of rs10491334 in CAMK4 was associated with hypertension in the Uygur group.
Expression of CaMKIV inhibits autophosphorylation and activation of CaMKII (show CAMK2G Proteins), and elicits G0/G1cell cycle arrest,impairing cell proliferation.
An imbalance of specific isoforms of CYFIP1 (show CYFIP1 Proteins), an FMRP (show FMR1 Proteins) interaction partner, and CAMK4, a transcriptional regulator of the FMRP (show FMR1 Proteins) gene, modulates risk for autism spectrum disorders.
CaMK4-dependent activation of AKT (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) and CREM (show CREM Proteins)-alpha underlies autoimmunity-associated Th17 imbalance.
CaMK4 regulates beta-cell proliferation and apoptosis in a CREB (show CREB1 Proteins)-dependent manner and CaMK4-induced IRS-2 (show IRS2 Proteins) expression is important in these processes

Pig (Porcine) Calcium/calmodulin-Dependent Protein Kinase IV (CAMK4) interaction partners

Data suggest that Tyr (show TYR Proteins)(99) phosphorylated calmodulin, as compared to non-phosphorylated, binds with a higher affinity at the calmodulin binding site (rich in basic amino acids) of CaM kinase IV leading to increased activation of CaM kinase IV.
conclude that the hypoxia-induced increased activation of CaM kinase IV cascade increases with the increase in the degree of cerebral tissue hypoxia as measured by cerebral tissue high energy phosphates in a curvilinear manner

Mouse (Murine) Calcium/calmodulin-Dependent Protein Kinase IV (CAMK4) interaction partners

CaMKIV can act as an immunostimulation molecule and enhances the acute muscle inflammatory responses.
CaMKIV knockdown selectively inhibits pro-inflammatory cytokines/chemokines, and co-stimulatory molecules expression in IFN-gamma (show IFNG Proteins) treated myoblasts and myotubes and abolishes IFN-gamma induced (show SAMHD1 Proteins) CREB (show CREB1 Proteins) pathway molecules accumulation in differentiated myotubes.
Activation of CaMKIV by soluble amyloid-beta1-42 impedes trafficking of axonal vesicles and impairs activity-dependent synaptogenesis.
CaMKIV is a key regulator of neuronal intracellular HDAC4 (show HDAC5 Proteins) trafficking during stroke
Pharmacological inhibition of CaMK4 recapitulated the observed defects in Cryptococcus neoformans phagocytosis. Furthermore, mice deficient in CaMK4 showed increased survival compared to wild-type mice upon infection with Cryptococcus neoformans. This increase in survival correlated with decreased expression of pattern recognition receptors on host phagocytes known to recognize Cryptococcus neoformans.
results imply that CaMKIV plays a role in maintenance the structure of chromatoid body by regulating the associations of proteins in it
CaMK4 activity is increased in T cells from systemic lupus erythematosus mice compared with the control group.
Results demonstrated that genetically inhibiting the CaMKK (show CAMKK2 Proteins) pathway via CaMKKbeta or CaMK IV is detrimental in the response of female mice to cerebral ischemia
CaMKIV-mTOR (show FRAP1 Proteins)-dependent autophagy is conserved in both immune and nonimmune/parenchymal cells and is fundamental for the respective functional and adaptive responses to septic insult.
CaMK4-dependent activation of AKT (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) and CREM (show CREM Proteins)-alpha underlies autoimmunity-associated Th17 imbalance.

Zebrafish Calcium/calmodulin-Dependent Protein Kinase IV (CAMK4) interaction partners

We identified the zebrafish homologue of CaMKIV (zCaMKIV) on the basis of biochemical characterization. zCaMKIV showed similar biochemical properties as well as tissue and subcellular distributions to rat CaMKIV (rCaMKIV)

CAMK4 Protein Profile

Protein Summary

The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells.

Alternative names and synonyms associated with CAMK4

calcium/calmodulin dependent protein kinase IV (CAMK4)
calcium/calmodulin-dependent protein kinase IV (Camk4)
calcium/calmodulin-dependent protein kinase IV L homeolog (camk4.L)
calcium/calmodulin-dependent protein kinase IV (camk4)

A430110E23Rik protein
AI666733 protein
caMK protein
CaMK-GR protein
CAMK4 protein
camk4-A protein
CaMK IV protein
CaMKIV protein
CaMKIV/Gr protein
Ccdpk protein
D18Bwg0362e protein
IV protein
RATCCDPK protein
wu:fj42a03 protein
zgc:110275 protein

Protein level used designations for CAMK4

CAM kinase IV , CAM kinase- GR , brain Ca(2+)-calmodulin-dependent protein kinase type IV , brain Ca++-calmodulin-dependent protein kinase type IV , caM kinase-GR , calcium/calmodulin-dependent protein kinase type IV , calcium/calmodulin-dependent protein kinase type IV catalytic chain , calcium/calmodulin-dependent protein kinase IV , calcium/calmodulin-dependent protein kinase type IV-like , CAM kinase-GR , Ca2+/calmodulin-dependent protein kinase type IV/Gr , caMK IV , Calmodulin-dependent protein kinase IV , calspermin , zCaMKIV

GENE ID	SPECIES
814	Homo sapiens
712322	Macaca mulatta
100388410	Callithrix jacchus
100461605	Pongo abelii
100473015	Ailuropoda melanoleuca
100515364	Sus scrofa
100583900	Nomascus leucogenys
12326	Mus musculus
25050	Rattus norvegicus
373837	Xenopus laevis
461992	Pan troglodytes
550270	Danio rerio
723973	Gallus gallus
100684140	Canis lupus familiaris
100337083	Bos taurus

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