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Methylmalonic aciduria with homocystinuria cblC is a multisystemic metabolic disease affecting cobalamin metabolism. The presence of retinal alterations in cblC is a common feature and it is reported to develop more frequently and into a more severe form in the early-onset phenotype, suggesting to some extent a correlation with the biochemical phenotype
Data suggest that ubiquitin ligase CBLC controls mostly network organization of the Golgi Apparatus.
Silencing of CBLC causes increased sensitivity to PARP1 (show PARP1 Proteins) inhibitor olaparib in breast cancer cell line models and that defective homologous recombination (HR) DNA repair is the likely cause.
the effects of two pathogenic missense mutations on the the catalytic activities of the human B12 (show NDUFB3 Proteins)-processing chaperone CblC
This retrospective multicentre study evaluates clinical, biochemical and genetic findings in 88 cblC patients
The ubiquitin ligase activity of Cbl (show CBL Proteins)-c by the direct interaction of the LIM (show PDLIM5 Proteins) zinc coordinating domain of Hic5 (show TGFB1I1 Proteins) is demonstrated.
the N terminus of Cbl (show CBL Proteins)-c contributes to the binding to the E2 and phosphorylation of Tyr (show TYR Proteins)-341 leads to a decrease in affinity and an increase in the E3 activity of Cbl (show CBL Proteins)-c
Data demonstrate that two E3 ligases of different classes, CBLC and AIP4 (show ITCH Proteins), can interact and cooperate to down-regulate EGFR (show EGFR Proteins) signaling.
c-Cbl is a negative regulator of hepatocyte growth factor/receptor tyrosine kinase Met signaling in B cells, mediating ubiquitination and, consequently, proteosomal degradation of Met, with a role in Met-mediated tumorigenesis.
Src (show SRC Proteins) is a preferential target of Cbl (show CBL Proteins)-c for degradation
bCblC, a bovine B12 (show TNFAIP1 Proteins) trafficking chaperone, catalyzes elimination of the glutathione ligand from GSCbl by using the reduced form of glutathione (GSH).
This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Cas-Br-M (murine) ecotropic retroviral transforming sequence c
, Cas-Br-M (murine) ectropic retroviral transforming sequence c
, Cbl proto-oncogene, E3 ubiquitin protein ligase C
, RING finger protein 57
, SH3-binding protein CBL-3
, SH3-binding protein CBL-C
, signal transduction protein CBL-C
, Casitas B-lineage lymphoma c
, E3 ubiquitin-protein ligase CBL-C