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This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Cas-Br-M (murine) ecotropic retroviral transforming sequence c
, Casitas B-lineage lymphoma c
, Cbl proto-oncogene, E3 ubiquitin protein ligase C
, SH3-binding protein CBL-3
, SH3-binding protein CBL-C
, signal transduction protein CBL-C
, Cas-Br-M (murine) ectropic retroviral transforming sequence c
, RING finger protein 57