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the p130Cas (show BCAR1 ELISA Kits) FAT domain uniquely confers a mechanosensing function.
These results uncover a new role for p120 catenin bound to the N-cadherin (show CDH2 ELISA Kits) precursor ensuring its trafficking through the biosynthetic pathway towards the cell surface.
The BC cells showed the coexpression of E- and P-cadherins, as well as release of the molecules b- and p120-catenins into the cytoplasm of tumor cells, which leads to the activation of intracellular mechanisms for changing the structure of the cytoskeleton and the level of proliferation
recent results describing actions of p120-catenin in different phases of this pathway
The mTOR (show FRAP1 ELISA Kits)-dependent, epithelial phenotype of TSC (show SLC12A3 ELISA Kits) astrocytes suggests TSC1 (show TSC1 ELISA Kits)/2 and mTOR (show FRAP1 ELISA Kits) tune the phosphorylation level of catenin delta-1 by controlling PKCe (show PRKCE ELISA Kits) activity, thereby regulating the mesenchymal-epithelial-transition (MET)
Src (show SRC ELISA Kits)-dependent phosphorylation of p120(ctn) can respond rapidly to negative pressure and contribute to E-cadherin (show CDH1 ELISA Kits) downregulation.
p120 (show HNRNPU ELISA Kits) participates in the progress of gastric cancer through regulating Rac1 and Pak1 (show PAK1 ELISA Kits).
The overexpression of P120ctn led to a decrease in both invasion and migration capacity of HN12 cells accompanied by a decrease in EMT (show ITK ELISA Kits) markers. Knockdown of P120ctn led to an increase in both invasion and migration capacity accompanied by an increase in EMT (show ITK ELISA Kits) markers.
Tyrosine phosphorylation of focal adhesion kinase (FAK) and p130 (show RBL2 ELISA Kits) Crk-associated substrate (CAS (show BCAR1 ELISA Kits)) was found to be correlated with pancreatic cancer cell invasiveness.
Full-length and truncated p130Cas (show BCAR1 ELISA Kits) phosphorylated substrate domain molecules were expressed in breast cancer cells. Breast cancer cells expressing the full-length SD and the functional smaller SD fragment (spanning SD motifs 6-10) were injected into the mammary fat pads of mice. Both the complete and truncated SD significantly increased the occurrence of metastases to multiple organs.
p120 Catenin underexpression is associated with Invasive Pancreatic Neoplasia.
We conclude that p120ctn is not only an adaptor and regulator of E-cadherin (show CDH1 ELISA Kits), but is also indispensable for proper lineage commitment
p120 is required for dietary calcium suppression of oral carcinogenesis.
p120ctn has a critical role in biliary differentiation and is a potent suppressor of liver tumor growth.
a mechanistic link between E-cadherin (show CDH1 ELISA Kits) loss and subsequent control of Rho-driven anoikis resistance through p120- and Kaiso (show ZBTB33 ELISA Kits)-dependent expression of Wnt11 (show WNT11 ELISA Kits), is reported.
Delta-catenin (show CTNND2 ELISA Kits) activates Rac1 and Cdc42 (show CDC42 ELISA Kits) but inhibits RhoA (show RHOA ELISA Kits) in lymphatic endothelial cells.
p120-catenin regulates REST and CoREST (show Rcor2 ELISA Kits) and modulates mouse embryonic stem cell differentiation.
Data indicate that p120 catenin is required for proper pancreatic tubulogenesis and branching morphogenesis.
p120-RhoA-GTPase-mediated signaling can differentially regulate the migratory behavior of epidermal cells, which has potential implications for chronic wound responses and cancer.
p120 functions as a differential regulator of TLR4 signaling pathways by facilitating TLR4 endocytic trafficking in macrophages, and support a novel role for p120 in influencing the macrophages in the lung inflammatory response to endotoxin.
Upregulation of Rac1 activity by Wnt3a (show WNT3A ELISA Kits) temporally correlated with enhanced p120-catenin binding to Rac1 and Vav2 (show VAV2 ELISA Kits).
p120ctn signaling in motor neurons promotes nerve-muscle interaction and neuromuscular junction assembly
Dyrk1A (show DYRK1A ELISA Kits) positively and selectively modulates p120-catenin protein levels, thus having an impact on p120-catenin and Kaiso (show ZBTB33 ELISA Kits) (and canonical Wnt (show WNT2 ELISA Kits)) gene targets such as siamois and wnt11.
The degradation machinery of the canonical Wnt (show WNT2 ELISA Kits) pathway modulates p120-catenin protein stability through mechanisms shared with those regulating beta-catenin (show CTNNB1 ELISA Kits).
delta-catenin (show CTNND2 ELISA Kits) has an essential role in amphibian development, and has functional links to cadherins and Rho-family GTPases
This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined. Read-through transcription also exists between this gene and the neighboring upstream thioredoxin-related transmembrane protein 2 (TMX2) gene.
cadherin-associated Src substrate
, catenin delta-1
, p120 catenin
, catenin src
, catenin (cadherin-associated protein), delta 1
, catenin delta-1 isoform 1AC
, catenin, delta 1
, catenin delta-1-like