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Results suggest that zebrafish may be used as a model organism to address the function of PLCepsilon 1 during the development of organs.
Our results demonstrate that PLCE1 haplotypes (including rs2274223 and rs3765524) and expression combined with serum AFP (show AFP Proteins) level may predict postoperative outcome of HBV-related HCC (show FAM126A Proteins) patients.
high expression of both PLCE1 and PRKCA (show PKCa Proteins) is significantly associated with poor outcomes of the patients with esophageal cancers.
rs10882379 and rs829232 SNPs in the PLCE1 gene may contribute to the esophageal squamous cell carcinoma (ESCC) susceptibility in Chinese Han population. Also the gene-gene and gene-environment interactions play a certain crucial role in the ESCC progression.
No association between PLCE1 genotype and early viremia level in dengue patients.
PLCE1 single-nucleotide polymorphism is associated with migraine.
PLCE1 expression was found in the invasive carcinoma but not in the carcinoma in situ samples. Snail (show SNAI1 Proteins) expression in the human ESCC samples significantly correlated with the PLCE1 protein level, and expression of Snail (show SNAI1 Proteins) target genes in human esophageal cancer samples were also correlated with the PLCE1 abundance.
results have shown a novel role of PLCepsilon in the maintenance of endothelial barrier function, via its CDC25 GEF domain and lipase activity, and subsequent up-regulation of Rap1 activity
High PLC (show HSPG2 Proteins) epsilon expression is associated with breast cancer.
The mRNA expressions of PPP3CB (show PPP3CB Proteins) and MEF2C (show MEF2C Proteins) were significantly up-regulated, and CAMK1 (show CAMK1 Proteins) and PPP3R1 (show PPP3R1 Proteins) were significantly down-regulated in mitral regurgitation(MR) patients compared to normal subjects. Moreover, MR patients had significantly increased mRNA levels of PPP3CB (show PPP3CB Proteins), MEF2C (show MEF2C Proteins) and PLCE1 compared to aortic valve disease patients
Two novel putatively deleterious PLCE1 variants were identified in children with steroid-resistant nephrotic syndrome.
The first SNP rs29972765 is located in a gene desert on chromosome 18, about 72 kb upstream of Skor2 . The second SNP rs30415957 resides in the intron of Plce1.The remaining two SNPs (rs30768258 and rs31216810) are close to each other on chromosome 19, in the vicinity of Sorbs1 (show SORBS1 Proteins). Knockdown of Sorbs1 (show SORBS1 Proteins) by siRNA attenuates the induction of differentiation marker gene Prl8a2
2-arachidonoylglycerol (2-AG) is an endogenous cannabinoid that depresses synaptic transmission through stimulation of CB1 (show CNR1 Proteins) receptors. Among the six isoforms of phospholipase C (PLC (show PLC Proteins); PLCbeta, PLCgamma, PLCdelta, PLCepsilon, PLCzeta (show PLCz1 Proteins), PLCeta), only PLCbeta has been linked to 2-AG synthesis. Here we demonstrate that 8-CPT (show DHDDS Proteins)-2Me-cAMP, a selective agonist of the cAMP sensor protein Epac (show RAPGEF3 Proteins), enhances 2-AG-mediated synaptic depress...
study shed light on a novel role of PLCepsilon in wound healing and provided new therapeutic approaches to target PLCepsilon for diminishing scar formation after injury
PLCepsilon is crucial for N-butyl-N-(4-hydroxybutyl) nitrosamine induced bladder carcinogenesis.
Thrombin (show F2 Proteins) promotes sustained signaling and inflammatory gene expression through the CDC25 (show CDC25C Proteins) and Ras-associating domains of phospholipase C epsilon.
PLCepsilon plays an important role in the pathogenesis of bronchial asthma through upregulating inflammatory cytokine production by the bronchial epithelial cells.
a new pathway for TRPC6 (show TRPC6 Proteins) activation by Phospholipase C epsilon
findings reveal a pathway initiated by GPCR (show GPBAR1 Proteins) agonist-induced RhoA (show RHOA Proteins) activation, in which PLCepsilon signals to PKD1 (show PKD1 Proteins)-mediated phosphorylation of cytoskeletal proteins
Activity of PLCepsilon contributes to chemotaxis of fibroblasts towards PDGF (show PDGFA Proteins).
PLCepsilon links G protein-coupled receptors (GPCR (show GPBAR1 Proteins)) to sustained PKD (show PRKD1 Proteins) activation, providing a means for GPCR (show GPBAR1 Proteins) ligands that couple to RhoA (show RHOA Proteins) to induce NF-kappaB (show NFKB1 Proteins) signaling and promote neuroinflammation.
This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome\; characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
phospholipase C, epsilon 1
, pancreas-enriched phospholipase C
, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon-1
, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon-1-like
, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
, phosphoinositide phospholipase C-epsilon-1
, phosphoinositide-specific phospholipase C epsilon-1
, phospholipase C-epsilon-1
, phospholipase C epsilon