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Human Protein Tyrosine Phosphatase Receptor Type F (PTPRF) interaction partners

1. Data show that protein tyrosine phosphatase receptor type F (PTPRF) activity suppressed CD133/transmembrane 4L six family member 5 (TM4SF5)-mediated sphere growth.

2. transferred nuclear Overhauser effects (trNOEs) have been employed in the docking program HADDOCK to generate models for the LAR-fondaparinux complex. These models are further analyzed by postprocessing energetic analysis to identify key binding interactions.

3. PTPRF may have value as a predictive marker to identify which patients can obtain the greatest benefit from erlotinib in the post-first-line setting.

4. Homozygous truncating PTPRF mutation causes athelia.

5. PTPRF is down-regulated in hepatocellular carcinoma-facilitated tumor development.

6. Interaction between the tripartite NGL-1, netrin-G1 and LAR adhesion complex promotes development of excitatory synapses.

7. LAR functions as a negative regulator of adipogenesis.

8. Trans-synaptic adhesions between netrin-G ligand-3 (NGL-3) and receptor tyrosine phosphatases LAR, protein-tyrosine phosphatase delta (PTPdelta), and PTPsigma via specific domains regulate excitatory synapse formation.

9. regulation of expression by cell density through functional E-cadherin complexes

10. interactions between RPTP-domain1s and RPTP-domain 2s are a common but specific mechanism that is likely to be regulated- domain2s and the wedge structures are crucial determinants of binding specificity, thus regulating cross-talk between RPTPs

11. LAR PTPase domains play distinct functional roles in phosphorylation and dephosphorylation

12. LAR as a crucial regulator of the sensitivity of two key insulin signalling pathways to insulin

13. Results identify a protein tyrosine phosphatase as a potential substrate of TACE and describe proteolytic processing of PTP-LAR as a means of regulating phosphatase activity downstream and thus under the control of EGFR-mediated signaling pathways.

14. PS/gamma-secretase-mediated cleavage of LAR controls LAR-beta-catenin interaction, suggesting an essential role for PS/gamma-secretase in the regulation of LAR signaling

15. Regulated degradation of liprinalpha1 is important for proper LAR receptor distribution, and could provide a mechanism for localized control of dendrite and synapse morphogenesis by activity and CaMKII.

16. LAR and Src are identified as Death-associated protein kinase (DAPK) regulators through their reciprocal modification of DAPK Y491/492 residues and establishes a functional link of this DAPK-regulatory circuit to tumor progression.

17. the PTPase activity in patients with insulin receptor gene mutation and severe insulin resistance may differ from that in ordinary type 2 diabetes

Mouse (Murine) Protein Tyrosine Phosphatase Receptor Type F (PTPRF) interaction partners

1. We show that PTP-3, a LAR homolog in Caenorhabditis elegans, participates in Sema2A-regulated axon guidance. PTPdelta, a member of vertebrate LAR class PTPs, is involved in Sema3A-regulated cortical dendritic growth. In Sema3A signaling, PTPdelta activates Fyn and Src kinases by dephosphorylating their C-terminal Tyr residues.

2. loss of LAR activity resulted in reduced activity of CDK1.

3. Study has identified LAR as a regulator of key signaling pathways, including mTOR and JNK, and has significantly expanded the number of proteins regulated downstream of LAR phosphatase activity.

4. Chondroitin Sulfate Proteoglycans Negatively Modulate Spinal Cord Neural Precursor Cells by Signaling Through LAR and RPTPsigma and Modulation of the Rho/ROCK Pathway.

5. This study demonstrates the crucial role of LAR in restricting regrowth of injured CNS axons

6. Ptprs and Ptprf deficiency affects mandibular cell proliferation.

7. Inhibition of LAR attenuates palmitate-induced insulin resistance in myotubes.

8. Deletion of LAR in knock-out mice or blockade of LAR with sequence-selective peptides significantly overcomes neurite growth restrictions of chondroitin sulfate proteoglycan in neuronal cultures.

9. the crystal structures of the first and second immunoglobulin-like domains of the Drosophila type IIa receptor Dlar and its mouse homolog LAR were reported.

10. LAR reduces the basal c-Abl activity thereby allowing for platelet derived growth factor beta receptor kinase activation

11. LAR deficiency affected the differentiation & expansion of immature thymocytes, positive & negative selection, & a lower Ca2+ response. LAR is an important modulator of TCR signaling that controls thymocyte differentiation.

12. LAR PTPase domains play distinct functional roles in phosphorylation and dephosphorylation

13. PTP alpha is required for integrin-proximal events and phosphorylates FAK

14. In conclusion, behavioural testing of the LAR tyrosine phosphatase-deficient mice revealed a spatial learning impairment and a significant increase in activity.

15. LAR enhances retinal ganglion cell neurite initiation whilst suppressing retinal ganglion cell survival

16. Results introduce leukocyte common antigen-related (LAR) protein tyrosine phosphatase (PTP) as the first PTP found to be expressed in dentate progenitors and point to inhibition of LAR as a potential strategy for promoting neurogenesis.

17. Here, we report rapid and efficient construction of PTPRF and NWC TgVs without using restriction endonucleases.

Zebrafish Protein Tyrosine Phosphatase Receptor Type F (PTPRF) interaction partners

1. Presynaptic PTPsigma controls the number of olfactory sensory neuron and mitral cell synapses by suppressing excessive increase of axon terminals.