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Full name:: Protein tyrosine Phosphatase, Receptor Type, J Proteins (PTPRJ)

On www.antibodies-online.com are 13 Protein tyrosine Phosphatase, Receptor Type, J (PTPRJ) Proteins from 6 different suppliers available. Additionally we are shipping PTPRJ Antibodies (138) and PTPRJ Kits (10) and many more products for this protein. A total of 162 PTPRJ products are currently listed.

Synonyms:: AI450271, BET, Byp, CD148, DEP-1, DEP1, HPTPeta, Ptpb2, PTPbeta2, PTPRJ, R-PTP-ETA, RPTPJ, Scc-1, Scc1

list all proteins	Gene Name	GeneID	UniProt
	PTPRJ	29645
	PTPRJ	5795	Q12913
	PTPRJ	19271	Q64455
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Human Protein tyrosine Phosphatase, Receptor Type, J (PTPRJ) interaction partners

Short variant of the receptor protein phosphatase PTPRJ generated by an alternative splicing promotes angiogenesis in HUVEC cells and tumor angiogenesis.
study reveals the crucial role of miR (show MLXIP Proteins)-155/PTPRJ/AKT (show AKT1 Proteins) axis in proliferation and migration of colorectal cancer cells and suggests a therapeutic potential of PTPRJ.
Authors demonstrate that mtp53 prevents the COP1 (show CARD16 Proteins)/DET1 complex from ubiquitinating ETS2 (show ETS2 Proteins) and thereby marking it for destruction. Authors show that mtp53 destabilizes DET1 and also disrupts the DET1/ETS2 (show ETS2 Proteins) complex thereby preventing ETS2 (show ETS2 Proteins) degradation.
These data support that PTPN22 (show PTPN22 Proteins) 1858C/T, PTPRJ 2965C/G and 1176 A/C polymorphisms and ACP1 A (show ACP1 Proteins), B and C alleles are not associated with a higher risk of immune thrombocytopenia P in adults.
Loss of PTPRJ expression may predict an aggressive clinical course in ESCC patients.
The strongest association with frailty was observed in the Protein Tyrosine Phosphatase (show ACP1 Proteins), Receptor type, J (PTPRJ) (rs1566729, P = 0.001372, beta = 0.09397) gene.
the combination of CD200 (show CD200 Proteins) and CD148 may have a potential differential diagnostic value in leukemic B-CLPDs, especially between CLL and MCL (show FH Proteins).
These results demonstrated Ptprj as a physiological enzyme that attenuates insulin (show INS Proteins) signalling in vivo, and indicate that an inhibitor of Ptprj may be an insulin (show INS Proteins)-sensitizing agent.
CD148 tyrosine phosphatase promotes e-cadherin (show CDH1 Proteins) cell adhesion.
The studies suggest induction of MMP-9 (show MMP9 Proteins) expression promoted by DEP-1 deficiency.

Mouse (Murine) Protein tyrosine Phosphatase, Receptor Type, J (PTPRJ) interaction partners

This study demonstrated that the protein-tyrosine phosphatase (show ACP1 Proteins) DEP-1 promotes migration and phagocytic activity of microglial cells in part through negative regulation of fyn (show FYN Proteins) tyrosine kinase (show TYRO3 Proteins).
our results established DEP-1 as an essential driver of VEGF (show VEGFA Proteins)-dependent permeability, angiogenesis, and metastasis
These results demonstrated Ptprj as a physiological enzyme that attenuates insulin (show INS Proteins) signalling in vivo, and indicate that an inhibitor of Ptprj may be an insulin (show INS Proteins)-sensitizing agent.
DEP-1 acts as an endogenous antagonist of the insulin receptor (show INSR Proteins), and downregulation of DEP-1 results in an improvement of insulin (show INS Proteins) sensitivity.
Data indicate that CD148 mRNA is upregulated in diseased joints of with collagen-induced arthritis.
The large ectodomains of CD45 and CD148 modulate their inhibitory effect by enabling their passive, size-based segregation from ligated TCR, supporting the kinetic-segregation model of TCR triggering.
phosphatase CD148 promotes airway hyperresponsiveness through SRC (show SRC Proteins) family kinases
These data indicate that PTPRJ may regulate differentiation of normal mammary epithelia and that dysregulation of protein localisation may be associated with tumorigenesis.
CD148 plays a dominant role in activating Src (show SRC Proteins) family kinases in platelets relative to PTP-1B (show PTPN1 Proteins). Both PTPs (show PTS Proteins) are required for optimal platelet activation and aggregate formation under high arterial shear rates.
CD45 and CD148 preferentially target different SFK members (Hck and Fgr versus Lyn, respectively) to positively and negatively regulate GPCR pathways.

PTPRJ Protein Profile

Protein Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with PTPRJ

protein tyrosine phosphatase, receptor type, J (Ptprj)
protein tyrosine phosphatase, receptor type J (PTPRJ)
protein tyrosine phosphatase, receptor type, J (PTPRJ)
protein tyrosine phosphatase, receptor type, J (EUBREC_2762)

AI450271 protein
BET protein
Byp protein
CD148 protein
DEP-1 protein
DEP1 protein
HPTPeta protein
Ptpb2 protein
PTPbeta2 protein
PTPRJ protein
R-PTP-ETA protein
RPTPJ protein
Scc-1 protein
Scc1 protein

Protein level used designations for PTPRJ

, , , , , , , , , , , , , , , , , , receptor-type tyrosine-protein phosphatase eta density enhanced phosphatase-1 protein tyrosine phosphatase, receptor type, J receptor-type tyrosine-protein phosphatase eta-like CD148 antigen DEP-1 HPTP eta R-PTP-J density-enhanced phosphatase 1 human density enhanced phosphatase-1 protein tyrosine phosphatase, receptor type, J polypeptide protein-tyrosine phosphatase eta protein-tyrosine phosphatase receptor type J susceptibility to colon cancer 1, mouse, homolog of HPTP beta-like tyrosine phosphatase R-PTP-eta colon tumor susceptibility 1 susceptibility to colon cancer 1 supporting-cell antigen

GENE ID	SPECIES
29645	Rattus norvegicus
451181	Pan troglodytes
483617	Canis lupus familiaris
527664	Bos taurus
7964783	Eubacterium rectale ATCC 33656
100058689	Equus caballus
100082831	Ornithorhynchus anatinus
100219143	Taeniopygia guttata
100347798	Oryctolagus cuniculus
100401167	Callithrix jacchus
100484047	Ailuropoda melanoleuca
5795	Homo sapiens
19271	Mus musculus
395330	Gallus gallus

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