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Human SOX9 Protein expressed in HEK-293 Cells - ABIN2732475
Shi, Chiang, Labhart, Zhao, Yang, Mistretta, Henning, Maity, Mori-Akiyama: Context-specific role of SOX9 in NF-Y mediated gene regulation in colorectal cancer cells. in Nucleic acids research 2015
Our results demonstrate that the linc-ROR-miRNA-SOX9 regulatory network may represent a novel therapeutic target for esophageal squamous cell carcinoma
These results indicate that THRAP3 negatively regulates SOX9 transcriptional activity as a cofactor of a SOX9 transcriptional complex during chondrogenesis.
MiR (show MLXIP Proteins)-19a could promote cell viability and migration of chondrocyte via positively regulating SOX9 expression through NF-kappaB (show NFKB1 Proteins) signaling pathway.
miR (show MLXIP Proteins)-185 inversely regulates SOX9 expression in non-small cell lung cancer.
Data suggest that the SOX9 transcription factor (SOX9)-fibroblast growth factor receptor 2 (show FGFR2 Proteins) (FGFR2b) feed-forward loop has a lineage dependency role in pancreatic ductal adenocarcinoma (PDAC).
Depletion of KDM6A (show KDM6A Proteins) inhibits the expression of SOX9, Col2a1 (show COL2A1 Proteins), ACAN (show ACAN Proteins) and results in increased H3K27me3 and decreased H3K4me3 levels.
Our results demonstrate that SOX9 plays a crucial role in chordoma. Targeting SOX9 provides a new rationale for treatment of chordoma
Odd-skipped related 1 (OSR1 (show OSR1 Proteins)) downregulated the activity of the Wnt (show WNT2 Proteins) signaling pathway by suppressing the expression of sex-determining region Y (show SRY Proteins)-box 9 (SOX9) and beta-catenin (show CTNNB1 Proteins).
Sex determining region Y (show SRY Proteins) box 9 (Sox9) plays an important role in chemoresistance by the induction of stemness in pancreatic cancer cells.
Knockdown of SOX9 expression by RNA interference reduces cell proliferation and induces apoptosis of lung cancer cells, which was consistent with the results obtained from silencing the expression of LASP-1 (show LASP1 Proteins) in NCIH1650 cells.
Analysis of tissue maturation markers showed an increase in COLL II and a decrease in SOX9 expression in the swine tibial menisci with age.
The expression of the differentiation and stemness genes, FN1 (show FN1 Proteins) and SOX9, is accompanied by cell proliferation.
data presented here demonstrate that the 18 bp indel in the porcine SOX9 5'-UTR is of functional importance and may therefore indeed be a causative variation in SOX9 associated traits
HIF-1alpha (show HIF1A Proteins) activates Sox9 expression and enhances Sox9-mediated transcriptional activity.
a novel regulatory relationship between the retinal pigmented epithelium (RPE (show RPE Proteins)) transcription factors Pax6 (show PAX6 Proteins) and Sox9 that controls the timing of RPE (show RPE Proteins) differentiation and the adjacent choroid maturation, is reported.
enhancer 13, a 557-base pair element located 565 kilobases 5' from the transcriptional start site, is essential to initiate mouse testis development; its deletion results in XY females with Sox9 transcript levels equivalent to those in XX gonads.
Sox9 is identified as important factor of VSMC function by modulation the extracellular matrix composition and calcium deposition, which are important processes in plaque development.
these findings widen our current knowledge of SOX9 targets in early chondrogenesis and call for new studies to identify the pioneer and transactivating factors that act upstream of or along with SOX9 to prompt chromatin remodeling and specific gene activation at the onset of chondrogenesis and other processes.
The data support a model of SOX9-GLI (show GLI1 Proteins)-FOXA phasic gene regulatory network in chondrocyte development. Together, SOX9-GLI (show GLI1 Proteins) auto-regulate and cooperate to activate and repress genes in proliferating chondrocytes. Upon hypertrophy, FOXA competes with SOX9, and control toward terminal differentiation passes to FOXA, RUNX, AP1 (show JUN Proteins) and MEF2 (show MEF2C Proteins) factors.
Ctgf (show CTGF Proteins) is the direct target gene of SOX9 in chondrocytes and nucleus pulposus cells.
MOB1 (show HOPX Proteins)-dependent YAP1 (show YAP1 Proteins)/TAZ (show TAZ Proteins)-TEAD complex functions as a transcriptional repressor of SOX9 and thereby negatively regulates chondrogenesis.
the novel role of Tgfb2 (show TGFB2 Proteins), Fbxl18 (show FBXL18 Proteins), and Tle3 in formation of Sox5 (show SOX5 Proteins), Sox6, and Sox9 dependent tissues.
A critical level of endogenous active SOX9 needed to maintain colorectal tumor cell growth.
The protein encoded by this gene recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. It acts during chondrocyte differentiation and, with steroidogenic factor 1, regulates transcription of the anti-Muellerian hormone (AMH) gene. Deficiencies lead to the skeletal malformation syndrome campomelic dysplasia, frequently with sex reversal.
SRY (sex determining region Y)-box 9
, SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal)
, transcription factor SOX-10
, SRY (sex-determining region Y)-box 9 protein
, SRY-related HMG-box, gene 9
, transcription factor SOX-9
, SRY-box containing protein 9
, SRY-box containing gene 9
, transcription factor SOX9