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Human SOX9 Protein expressed in HEK-293 Cells - ABIN2732475
Shi, Chiang, Labhart, Zhao, Yang, Mistretta, Henning, Maity, Mori-Akiyama: Context-specific role of SOX9 in NF-Y mediated gene regulation in colorectal cancer cells. in Nucleic acids research 2015
Biomarker expression in pancreatic ductal adenocarcinoma (PDAC) of CXCR4, SMAD4, SOX9 and IFIT3 will be prospectively assessed by immunohistochemistry and verified by rt.-PCR from tumor and adjacent healthy pancreatic tissue of surgical specimen.
A critical level of endogenous active SOX9 needed to maintain colorectal tumor cell growth.
ERG (show ERG Proteins) and SOX9 are potential biomarkers for prediction of response to docetaxel treatment in metastatic castration-resistant prostate cancer patients.
We have provided evidence that truncating mutations in SOX9 (particularly exon 3 truncating mutations) are recurrent in colorectal carcinoma
This study suggested that G allele at rs12941170 was protective, which could decrease the risk for NSOCs from Western Han Chinese population.
HSP60 (show HSPD1 Proteins) regulation of SOX9 ubiquitination mitigates the development of knee osteoarthritis.
Data show that SOX9 regulates CEACAM1 (show CEACAM1 Proteins) primarily via Sp1 (show PSG1 Proteins) and ETS1 (show ETS1 Proteins).
Sox9 confers stemness properties of hepatocellular carcinoma through Frizzled-7 mediated Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway.
Data show that the gene encoding the transcription factor SOX9 was identified by a global transcriptomic approach as an HDAC9 (show HDAC9 Proteins) target gene.
SOX9 is a proliferation and stem cell factor (show KITLG Proteins) in hepatocellular carcinoma and possess widespread prognostic significance in different cancer types
The expression of the differentiation and stemness genes, FN1 (show FN1 Proteins) and SOX9, is accompanied by cell proliferation.
data presented here demonstrate that the 18 bp indel in the porcine SOX9 5'-UTR is of functional importance and may therefore indeed be a causative variation in SOX9 associated traits
HIF-1alpha (show HIF1A Proteins) activates Sox9 expression and enhances Sox9-mediated transcriptional activity.
The spatiotemporal expression of Sox9 suggested its possible involvement during mouse incisor development.
both the local oxygen environment and WT1 (show WT1 Proteins), which enhances KDR (show KDR Proteins) expression, contribute to sex-specific Sox9 expression in developing murine gonads
This resulted in a delay in the birth of OPCs and subsequent developmental aberrations in these cells in the Sox9-deficient mice.
NF-alpha1 is critical for regulating antiproliferation and cell fate determination, through differentiating embryonic stem cells to GFAP (show GFAP Proteins)-positive astrocytes for normal neurodevelopment.
Interactions between the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) and the Kras/ERK (show EPHB2 Proteins)/Foxm1 (show FOXM1 Proteins) pathways are essential to restrict SOX9 expression in basal cells during lung morphogenesis
Hypomethylation in the Sox9 promoter is correlated to increased Sox9 expression in db/db (show LEPR Proteins) IESCs. Although there is increased expression of Sox9 in db/db (show LEPR Proteins) IESCs, the loss of Sox9 transcriptional activation in specific repressors of the Wnt (show WNT2 Proteins) signaling pathway might result in abnormalities in this pathway.
Concluding, this study shows that, in addition to its crucial role in testis development, Sox9, together with Sox8 (show SOX8 Proteins) and coordinately with Dmrt1 (show DMRT1 Proteins), also controls adult testis maintenance.
SOX9 regulation of ETV5 (show ETV5 Proteins) contributes to the control of male fertility
The protein encoded by this gene recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. It acts during chondrocyte differentiation and, with steroidogenic factor 1, regulates transcription of the anti-Muellerian hormone (AMH) gene. Deficiencies lead to the skeletal malformation syndrome campomelic dysplasia, frequently with sex reversal.
SRY (sex determining region Y)-box 9
, SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal)
, transcription factor SOX-10
, SRY (sex-determining region Y)-box 9 protein
, SRY-related HMG-box, gene 9
, transcription factor SOX-9
, SRY-box containing protein 9
, SRY-box containing gene 9
, transcription factor SOX9