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Human SOX9 Protein expressed in HEK-293 Cells - ABIN2732475
Shi, Chiang, Labhart, Zhao, Yang, Mistretta, Henning, Maity, Mori-Akiyama: Context-specific role of SOX9 in NF-Y mediated gene regulation in colorectal cancer cells. in Nucleic acids research 2015
Study found a positive relationship between LINC00052 and miR (show MLXIP Proteins)-101-3p, and a negative relationship between miR (show MLXIP Proteins)-101-3p and SOX9 in hepatocellular carcinoma (HCC (show FAM126A Proteins)) tissues. Besides, miR (show MLXIP Proteins)-101-3p was involved in LINC00052 inhibiting HCC (show FAM126A Proteins) cells proliferation and metastasis. At the molecular level, LINC00052 downgulated SOX9 to inhibit HCC (show FAM126A Proteins) cells proliferation and metastasis by interacting with miR (show MLXIP Proteins)-101-3p.
SOX9 expression is related to prognosis in patients with oesophageal squamous cell carcinoma, although it is not an independent prognostic factor.
the findings of this study establish the SOX9/CA9 (show CA9 Proteins)-mediated oncogenic pathway in glioma, the inhibition of which enhances the sensitivity of glioma cells to Temozolomide (TMZ) treatment, and thus highlights the value of developing small molecules or antibodies against the SOX9/CA9 (show CA9 Proteins) pathway, for combination therapy with TMZ, in the more efficient management of glioma
Heterogeneous Expression of Embryonal Development Master Regulator SOX9 in Patients with Pancreatic Cancer
Melatonin inhibits cancer stem cell by down-regulation of SOX9-mediated signaling pathway in osteosarcoma
Our results demonstrate that the linc-ROR-miRNA-SOX9 regulatory network may represent a novel therapeutic target for esophageal squamous cell carcinoma
These results indicate that THRAP3 negatively regulates SOX9 transcriptional activity as a cofactor of a SOX9 transcriptional complex during chondrogenesis.
MiR (show MLXIP Proteins)-19a could promote cell viability and migration of chondrocyte via positively regulating SOX9 expression through NF-kappaB (show NFKB1 Proteins) signaling pathway.
miR (show MLXIP Proteins)-185 inversely regulates SOX9 expression in non-small cell lung cancer.
Data suggest that the SOX9 transcription factor (SOX9)-fibroblast growth factor receptor 2 (show FGFR2 Proteins) (FGFR2b) feed-forward loop has a lineage dependency role in pancreatic ductal adenocarcinoma (PDAC).
ETV5 (show ETV5 Proteins) regulates ductal morphogenesis with Sox9 and is critical for regeneration from pancreatitis
a novel regulatory relationship between the retinal pigmented epithelium (RPE (show RPE Proteins)) transcription factors Pax6 (show PAX6 Proteins) and Sox9 that controls the timing of RPE (show RPE Proteins) differentiation and the adjacent choroid maturation, is reported.
enhancer 13, a 557-base pair element located 565 kilobases 5' from the transcriptional start site, is essential to initiate mouse testis development; its deletion results in XY females with Sox9 transcript levels equivalent to those in XX gonads.
Sox9 is identified as important factor of VSMC function by modulation the extracellular matrix composition and calcium deposition, which are important processes in plaque development.
these findings widen our current knowledge of SOX9 targets in early chondrogenesis and call for new studies to identify the pioneer and transactivating factors that act upstream of or along with SOX9 to prompt chromatin remodeling and specific gene activation at the onset of chondrogenesis and other processes.
The data support a model of SOX9-GLI (show GLI1 Proteins)-FOXA phasic gene regulatory network in chondrocyte development. Together, SOX9-GLI (show GLI1 Proteins) auto-regulate and cooperate to activate and repress genes in proliferating chondrocytes. Upon hypertrophy, FOXA competes with SOX9, and control toward terminal differentiation passes to FOXA, RUNX, AP1 (show JUN Proteins) and MEF2 (show MEF2C Proteins) factors.
Ctgf (show CTGF Proteins) is the direct target gene of SOX9 in chondrocytes and nucleus pulposus cells.
MOB1 (show HOPX Proteins)-dependent YAP1 (show YAP1 Proteins)/TAZ (show TAZ Proteins)-TEAD complex functions as a transcriptional repressor of SOX9 and thereby negatively regulates chondrogenesis.
Analysis of tissue maturation markers showed an increase in COLL II and a decrease in SOX9 expression in the swine tibial menisci with age.
The expression of the differentiation and stemness genes, FN1 (show FN1 Proteins) and SOX9, is accompanied by cell proliferation.
data presented here demonstrate that the 18 bp indel in the porcine SOX9 5'-UTR is of functional importance and may therefore indeed be a causative variation in SOX9 associated traits
HIF-1alpha (show HIF1A Proteins) activates Sox9 expression and enhances Sox9-mediated transcriptional activity.
Sox9 gene transfer could significantly enhance the repair effect of bone marrow mesenchymal stem cells on the degenerated discs.
The patterns of SRY (show SRY Proteins)/SOX9 expression associated with the process of gonadal morphogenesis in rabbit appear similar to those of other mammals, including humans.
The protein encoded by this gene recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. It acts during chondrocyte differentiation and, with steroidogenic factor 1, regulates transcription of the anti-Muellerian hormone (AMH) gene. Deficiencies lead to the skeletal malformation syndrome campomelic dysplasia, frequently with sex reversal.
SRY (sex-determining region Y)-box 9 protein
, SRY-related HMG-box, gene 9
, transcription factor SOX-9
, SRY (sex determining region Y)-box 9
, SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal)
, SRY-box containing gene 9
, SRY-box containing protein 9
, transcription factor SOX9
, LOW QUALITY PROTEIN: transcription factor SOX-9
, sex determining region Y-box 9
, transcription factor Sox-9-B
, transcription factor Sox9b