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The authors propose a structural organization where the AMSH-SH3 binding motif interacts with the STAM2-SH3 domain and contributes to the correct positioning of AMSH prior to polyubiquitin chains' cleavage.
The VHS domain of STAM2 directs AMSH to cleave longer Lys63-linked ubiquitin chains
homologous domain of human Bro1 domain-containing proteins, Alix and Brox, binds CHMP4B but not STAM2, despite their high structural similarity
correlation between the percentage of STAM2-positive cells and mitotic count was statistically significant in Gastrointestinal stromal tumors
The study reports the solution NMR structure of the STAM2-VHS domain in complex with monoubiquitin by means of chemical shift perturbations, spin relaxation, and paramagnetic relaxation enhancements.
the SH3 domain of STAM2 plays versatile roles in the context of ubiquitin mediated receptor sorting
Mice carrying a gene trap insertion in the Stam2 transgene do not reveal phenotype changes; therefore, STAM2 function in the digestive tube remains elusive.
report the interactions of the UIM domain and VHS-UIM construct of STAM2 with monoubiquitin (Ub), Lys(48)- and Lys(63)-linked diubiquitins.
PTP1B targets the endosomal sorting machinery; dephosphorylation of regulatory sites on the endosomal sorting complex is required for transport component STAM2
Data suggested that association with hepatocyte growth factor-regulated tyrosine kinase substrate is a prerequisite for STAM2 function in early endosome.
Rin1 regulates EGFR degradation in cooperation with STAM
STAMs function prominently in endoplasmic reticulum-to-Golgi trafficking, most likely through direct interactions with the coat protein II complex
Stam2 is expressed in the nervous tissue, heart, digestive and endocrine system during embryo development.
These results demonstrate that the STAMs are indispensably involved in T-cell development and survival in the thymus through the prevention of apoptosis but are dispensable for the proximal signaling of TCR and cytokine receptors.
STAM proteins function in a multivalent complex that sorts ubiquitinated proteins into the multivesicular body pathway.
SH3 domains of STAM2 and Grb2 retain the moderate characteristics of recognizing their ligand proteins like other SH3 domains for signal protein binding
plays important role in the mammalian endosomal/vacuolar protein sorting pathway
The G-102A polymorphism in STAM2 is significantly associated with withers height, heart girth, cannon circumference, chest width, and hip height in Wuchuan Black cattle
The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation.
, Hrs-binding protein
, STAM-like protein containing SH3 and ITAM domains 2
, signal transducing adapter molecule 2
, Hrs binding protein
, hrs-binding protein
, signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
, EAST protein
, epidermal growth factor receptor-associated protein with SH3 and TAM domain
, signal transducing adaptor molecule 2
, signal transducing adapter molecule 2-like