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This review analyzes the molecular mechanisms leading to TGFbeta (show TGFB1 Proteins) dysregulation in tumor and stroma cells and the modification of the microenvironment that fosters colorectal cancer metastasis. [review]
theses results suggest that TGF-beta1 (show TGFB1 Proteins) genotypes of recipient are the most associated with the risk of complications after haematopoietic stem cell transplantation
Studies indicate that transforming growth factor-beta (TGF-beta) signaling and receptor tyrosine kin (show KIN Proteins) (RTK) pathways interact with each other and their interplay is important for cancer development [Review].
We found that PD-L1 (show CD274 Proteins) expression was upregulated following TGF-beta (show TGFB1 Proteins) induction; in contrast, it was downregulated by TGF-beta (show TGFB1 Proteins) receptor-kinase inhibitors and the MET process. Furthermore, chemo-treatment increased TGF-beta (show TGFB1 Proteins) expression and enhances PD-L1 (show CD274 Proteins) expression via autocrine TGF-beta (show TGFB1 Proteins) induced EMT (show ITK Proteins). Analysis of clinical samples revealed a significant relationship between PD-L1 (show CD274 Proteins) expression and EMT (show ITK Proteins) status
TGF-beta1 (show TGFB1 Proteins) promotes cells invasion and migration by inducing epithelial mesenchymal transformation in oral squamous cell carcinoma
Genes TGFB1, TLE4 and MUC22 are associated with the risk of childhood asthma in Chinese population.
TGF-beta1 (show TGFB1 Proteins) efficiently converted human acinar cells to duct-like cells (AD) in a SMAD (show SMAD1 Proteins)-dependent manner, highlighting fundamental differences between the species
Plasma kallikrein (PLK)-dependent transforming growth factor-beta (TGF-beta) activation could be detected in isolated pancreatic stellate cells (PSCs) from chronic pancreatitis (CP) and pancreatic cancer.
rs1800469 in TGFB1 (show TGFB1 Proteins) was associated to hepatic decompensation in chronic hepatitis C, while the other 11 described polymorphisms must be evaluated in a larger cohort to determine the possible role of vitamin D in hepatitis C.
isatuximab decreases multiple myeloma cell- and bone marrow stromal cell-induced iTreg by inhibiting both cell-cell contact and TGFbeta/IL10. Finally, CD38 levels correlate with differential inhibition by isatuximab of Tregs from multiple myeloma versus normal donors.Targeting CD38 by isatuximab can preferentially block immunosuppressive Tregs and thereby restore immune effector function against multiple myeloma
TGF-beta1 (show TGFB1 Proteins) stimulated lubricin (show PRG4 Proteins) secretion by superficial zone chondrocytes at all densities with twice-a-week TGF-beta (show TGFB1 Proteins) treatment. It is noteworthy that the daily treatment of TGF-beta1 (show TGFB1 Proteins) increased lubricin (show PRG4 Proteins) much higher compared with twice-a-week treatment.
hypoxia increased the expression of platelet-derived growth factor (PDGF (show PDGFA Proteins)) and transforming growth factor-beta1 (TGF-beta1 (show TGFB1 Proteins)) and decreased the expression of neprilysin (NEP (show MME Proteins)), which contributed to the hypoxia-induced Endothelial-to-mesenchymal transition of pulmonary artery endothelial cells.
TGF-beta1 (show TGFB1 Proteins) modulates the expression of syndecan-4 (show SDC4 Proteins) in cultured vascular endothelial cells in a biphasic manner.
Taken together, Staphylococcus aureus induces TGF-beta1 (show TGFB1 Proteins) and bFGF (show FGF2 Proteins) expression through the activation of AP-1 (show JUN Proteins) and NF-kappaB (show NFKB1 Proteins) in bovine mammary gland fibroblasts.
The results identify TGFB1 (show TGFB1 Proteins) and ESRRA (show ESRRA Proteins) as likely transcriptional regulators of rumen epithelial development and energy metabolism, respectively, and provide targets for modulation of rumen development and function in the growing calf.
the combined treatment with TGF-beta1 (show TGFB1 Proteins) and BMP-7 (show BMP7 Proteins) or treatment first with TGF-beta1 (show TGFB1 Proteins) followed by BMP-7 (show BMP7 Proteins) was more effective than other treatment groups in both chondrogenic differentiation and SZP (show PRG4 Proteins) secretion.
Tenascin-X (show TNXB Proteins) promotes activation of latent TGF-beta1 (show TGFB1 Proteins) and subsequent epithelial to mesenchymal transition in mammary epithelial cells.
a detailed computational model for TGF-beta (show TGFB1 Proteins) signalling that incorporates elements of previous models together with crosstalking between Smad1 (show SMAD1 Proteins)/5/8 and Smad2 (show SMAD2 Proteins)/3 channels through a negative feedback loop dependent on Smad7 (show SMAD7 Proteins).
Endogenous TGF-beta1 (show TGFB1 Proteins) became more bioactive following activation of the transgene protein product in chondrocytes.
A novel peptide, P2K, regulating TGF-beta1 (show TGFB1 Proteins) signaling had an anabolic effect on bovine intervertebral disc cells and rabbit degenerated discs.
Data indicate that cardiac contractility modulation (CCM) therapy exerted protective effects against myocardial fibrosis potentially by inhibiting TGF-beta1 (show TGFB1 Proteins)/Smad3 (show SMAD3 Proteins) signaling pathway in chronic heart failure .
study suggested that TGF-beta1/Smad3/smad7 is a major pathway which plays an important role in the regulation of the IUA and specific inhibitor of Smad3 (SIS3) may provide a new therapeutic strategy for IUA.
cell therapy promoted TGF-beta1 (show TGFB1 Proteins) expression in nucleus pulposus, leading to anti-inflammatory effects via the inhibition of NF-kappaB (show NFKB1 Proteins), and the amelioration of disc degradation.
that prenatal tracheal occlusion increases TGF-beta (show TGFB1 Proteins)/Rho kinase (show ROCK1 Proteins) pathway, myofibroblast differentiation, and matrix deposition in neonatal rabbit and human congenital diaphragmatic hernia lungs
observation. Based on the above results, we conclude that TGF-beta1 (show TGFB1 Proteins)-immobilized PLGA-gelatin scaffold seeded with ASCs considerably enhances the quality of the tissue-engineered cartilage, therefore, advancing the field of cartilage tissue engineering
Smad7 (show SMAD7 Proteins) plays a crucial role in antagonizing epithelial-mesenchymal transition induced by TGFbeta (show TGFB1 Proteins) signaling and is a Notch (show NOTCH1 Proteins) signaling target in limbal epithelial stem cells.
the role of IL-10 in inhibited allograft rejection may be associated with CD4+CD25+ regulatory T cells and IL-10, and may be independent of TGF-b
After NOTCH1 (show NOTCH1 Proteins) knockdown and TGFB1 (show TGFB1 Proteins) stimulation, rabbit mesenchymal stem cells expressed higher levels of proteoglycan (show Vcan Proteins) and collagen II.
TGF-beta1 (show TGFB1 Proteins) gene transcription significantly correlates with the surgical vaginal and dermal wound closure rate.
TGF beta (show TGFB1 Proteins) is involved in the pathogenesis of tympanosclerosis.
There was significantly higher expression of TGF-beta1 (show TGFB1 Proteins) and MMP-9 (show MMP9 Proteins) in nasal mucosa of experimental allergic rhinitis guinea pigs than in controls.
TGF-beta1 (show TGFB1 Proteins) regulated pAKT (show AKT1 Proteins) and IFNgamma expressions were associated with epithelial cell survival in rhesus macaque colon explants and suggest a potential role of mucosal TGF-beta1 (show TGFB1 Proteins) in regulating intestinal homeostasis and EC integrity.
SIV infection of rhesus macaques results in the emergence of IL-17 (show IL17A Proteins)-expressing cells during the acute phase. This subpopulation appears at day 14 postinfection concomitantly with an increase in TGF-beta (show TGFB1 Proteins) and IL-18 (show IL18 Proteins) expression.
SIV-infected macaques exhibiting progression to AIDS displayed greater expression of TGF-beta (show TGFB1 Proteins) and indoleamine 2,3 dioxygenase in CD8 (show CD8A Proteins)+ T cells from mesentric lymph nodes.
TGF-beta1 (show TGFB1 Proteins) is activated or inactivated by MMP20 or KLK4 (show KLK4 Proteins) and that the amelogenin (show AMELX Proteins) cleavage product is necessary for the in-solution mobility of TGF-beta1 (show TGFB1 Proteins).
Activated TGF-beta (show TGFB1 Proteins) signaling rescued miR (show MYLIP Proteins)-143-reduced FSHR (show FSHR Proteins) and intracellular signaling molecules, and miR (show MYLIP Proteins)-143-induced porcine granulosa cell apoptosis.
TGF-beta1 (show TGFB1 Proteins)-induced epithelial-myofibroblast plasticity is FAK (show PTK2 Proteins)- dependent, whereas TGF-beta1 (show TGFB1 Proteins)-induced apoptosis is favored when FAK (show PTK2 Proteins) signaling is inhibited.
this study shows that TGF-beta1 (show TGFB1 Proteins) protects intestinal integrity and influences Smad (show SMAD1 Proteins) and MAPK (show MAPK1 Proteins) signal pathways in intestinal epithelium cells after TNF-alpha (show TNF Proteins) challenge
this study shows that anemonin may ameliorate LPS (show IRF6 Proteins)-induced intestinal injury and improve restoration by regulating the TGF-b1 and EGFR (show EGFR Proteins) signaling pathways
The results indicated that TGF-beta-1 (show TGFB1 Proteins) was associated with the restoration of intestinal morphology and barrier function following weaning stress.
Data (including data from in vitro and in vivo experiments) suggest that day 14 elongated conceptus secretes proteins that up-regulate TGFbeta1 (show TGFB1 Proteins) mRNA and TGFbeta1 (show TGFB1 Proteins) expression in endometrium; TGFbeta1 (show TGFB1 Proteins) may be important during pregnancy maintenance.
The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1 (show TGFB1 Proteins), IL-10 (show IL10 Proteins), and IL-6 (show IL6 Proteins) in ovarian follicles are reported.
Dietary (1,3/1,6)-beta-D-glucan reduced the mRNA expression of transforming growth factor (TGF) beta2 (show TGFB2 Proteins) and tended to reduce the mRNA expression of TGF-beta1 (show TGFB1 Proteins) in lung tissue of neonatal piglet.
TGF-beta1 (show TGFB1 Proteins), via TGF-beta1 (show TGFB1 Proteins) receptor I and p38 MAPK (show MAPK14 Proteins) signaling, reduces CFTR (show CFTR Proteins) expression to impair CFTR (show CFTR Proteins)-mediated anion secretion, which would likely compound the effects associated with mild CFTR (show CFTR Proteins) mutations and ultimately would compromise male fertility.
IL 6 (show IL6 Proteins) and TGF beta (show TGFB1 Proteins) perform essential role in cerebral malaria pathogenesis by modulating the level of glial cell induced neuroinflammation.
The increased susceptibility to IMQ-induced psoriasis of GILZ (show TSC22D3 Proteins)-Tg mice was significantly associated with skin-specific over-activation of TGF-beta1 (show TGFB1 Proteins)-mediated signaling via SMAD2 (show SMAD2 Proteins)/3.
The data suggest that B cells can down-regulate the function of antigen-presenting cells, and in turn encephalitogenic Th1 (show HAND1 Proteins)/Th17 responses, via TGF-beta1 (show TGFB1 Proteins).
p-SMAD2 (show SMAD2 Proteins)/3 and p-ERK1/2 might play a regulatory role in TGF-beta1 (show TGFB1 Proteins) induced CTGF (show CTGF Proteins) exp p-SMAD2 (show SMAD2 Proteins)/3 and p-ERK1/2 might play a regulatory role in TGF-beta1 (show TGFB1 Proteins) induced CTGF (show CTGF Proteins) expression during tooth development.
inhibiting NCAM1 (show NCAM1 Proteins) would be cardioprotective, counteract the pathological action of TGFbeta1 (show TGFB1 Proteins) and reduce heart failure severity.
TGF-beta (show TGFB1 Proteins) signaling has a role in inhibiting tumor progression and invasion in an induced mouse bladder cancer model
calpains inhibition plays crucial roles in vascular restenosis by preventing neointimal hyperplasia at the early stage via suppression of the MMP2 (show MMP2 Proteins)/TGF-beta1 (show TGFB1 Proteins) pathway.
Suggest an essential role for platelet-derived TGFbeta1 (show TGFB1 Proteins) for the vascular remodelling response to arterial injury, apparently independent from the role of platelets in thrombosis or haemostasis.
In cultured B16 melanoma and Bend3 endothelial cells treated with Bend3 conditioned media, MITF (show MITF Proteins), tyrosinase (show TYR Proteins), and melanin expression decreased due to TGFB1 (show TGFB1 Proteins) secreted by the endothelial cells.
Lycat regulates TGF-beta (show TGFB1 Proteins) mediated lung fibroblast differentiation in pulmonary fibrosis.
This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.
TGF-beta 1 protein
, latency-associated peptide
, transforming growth factor beta-1
, transforming growth factor, beta 1 (Camurati-Engelmann disease)
, transforming growth factor-beta 1
, transforming growth factor beta 1
, transforming growth factor-beta
, transforming growth factor beta1
, transforming growth factor-beta-1
, TGF-beta 1
, regulatory protein
, transforming growth factor, beta-1