Browse our TGFB1 Proteins (TGFB1)

Rhesus Monkey Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. TGF-beta1 regulated pAKT (show AKT1 Proteins) and IFNgamma expressions were associated with epithelial cell survival in rhesus macaque colon explants and suggest a potential role of mucosal TGF-beta1 in regulating intestinal homeostasis and EC integrity.

2. These findings suggest that FBLN5 (show FBLN5 Proteins) may interfere with choroidal neovascularization by downregulating VEGF (show VEGFA Proteins), CXCR4 (show CXCR4 Proteins), and TGFB1 expression and inhibiting choroidl endothelial cell proliferation.

3. SIV infection of rhesus macaques results in the emergence of IL-17 (show IL17A Proteins)-expressing cells during the acute phase. This subpopulation appears at day 14 postinfection concomitantly with an increase in TGF-beta and IL-18 (show IL18 Proteins) expression.

4. SIV-infected macaques exhibiting progression to AIDS displayed greater expression of TGF-beta and indoleamine 2,3 dioxygenase in CD8 (show CD8A Proteins)+ T cells from mesentric lymph nodes.

Zebrafish Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. transforming growth factor beta (TGFbeta) is required for hematopoietic progenitor cell specification. The requirement for TGFbeta is two fold and sequential: autocrine via Tgfbeta1a and Tgfbeta1b produced in the endothelial cells themselves, followed by a paracrine input of Tgfbeta3 from the notochord, suggesting that the former programs the hemogenic endothelium and the latter drives endothelial-to-hematopoietic tran...

2. The fine tuning of TGF-beta signaling derives from positive and negative control by Ldb2a (show LDB2 Proteins).

3. TGFbeta1a regulates zebrafish posterior lateral line formation via Smad5 (show SMAD5 Proteins) mediated pathway.

4. PCSK7 (show PCSK7 Proteins) is essential for zebrafish development and regulates the expression and proteolytic cleavage of TGFbeta1a.

5. TGFbeta signaling orchestrates the beneficial interplay between scar-based repair and cardiomyocyte-based regeneration to achieve complete heart regeneration.

6. TGFbeta1 plays a role in zebrafish keratocyte migration.

7. data presented show that Zili suppresses TGF-beta signaling by physically associating with Smad4 (show SMAD4 Proteins) and preventing the formation of Smad2 (show SMAD2 Proteins)/3/4 and Smad1 (show SMAD1 Proteins)/5/9/4 complexes

8. TGF-beta1 acts at multiple sites, including LH receptor (show LHCGR Proteins), 20beta-HSD (show HAL Proteins) and membrane progestin receptor-beta (show PAQR8 Proteins), to inhibit zebrafish oocyte maturation

9. These data suggest Pez (show PTPN14 Proteins) plays a crucial role in organogenesis by inducing TGFbeta and epithelial-mesenchymal transition.

10. Data show that Rock2 (show ROCK2 Proteins) acts as a negative regulator of the TGFbeta signaling pathway.

Xenopus laevis Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. These data indicate that TGF-beta signaling is crucial for the function of the transition zone, which in turn may affect the regulation of cilia length.

2. R-Smads are the key components of TGFbeta beta signals in germ layer induction. SCP3 (show SYCP3 Proteins) serves as a vegetally enriched, intrinsic factor (show GIF Proteins) to ensure a prepared status of Smads for their activation.

3. the present in vitro system, which permits not only the cell contraction-mediated cell sorting but also the TGF-b-directed mesodermal induction such as cartilage formation, may fairly reflect the embryogenesis in vivo.

4. Loss of XTgfbi impaired blastopore formation and dorsal tissue morphogenesis.

5. TGF-beta signaling has a role in nuclear localization of transcription factor Smad4 (show SMAD4 Proteins)

6. sortilin (show SORT1 Proteins) negatively regulates TGF-beta signaling by diverting trafficking of precursor proteins to the lysosome during transit through the biosynthetic pathway

Human Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. our findings suggest that tumor extracellular vesicle (EV)-educated mesenchymal stem cells promote osteosarcoma progression and provide the basis for testing IL6 (show IL6 Proteins)- and TGFbeta-blocking agents as new therapeutic options for osteosarcoma patients.

2. Lipopolysaccharides-mediated TLR4 (show TLR4 Proteins) signaling enhances TGF-beta response through downregulating BAMBI (show BAMBI Proteins) during prostatic hyperplasia.

3. This work additionally suggests ILEI (show FAM3C Proteins) mediates TGF-beta1-dependent Epithelial-to-mesenchymal transitions (EMTs) via the extracellular regulated protein kinases (ERKs) and protein kinase B (Akt (show AKT1 Proteins)) signalling pathways.

4. conclude that Lipin-1 (show LPIN1 Proteins) can antagonize HSC (show FUT1 Proteins) activation through the inhibition of TGF-beta/SMAD (show SMAD1 Proteins) signaling and that resveratrol may affect Lipin-1 (show LPIN1 Proteins) gene induction and contribute to the inhibition of TGF-beta-mediated hepatic fibrogenesis

5. SARS (show SARS Proteins) coronavirus papain-like protease significantly triggered Egr-1 (show EGR1 Proteins) dependent activation of TGF-beta1 promoter via reactive oxygen species/p38 MAPK (show MAPK14 Proteins)/STAT3 (show STAT3 Proteins) pathway.

6. TGF-beta1 has a role in stimulating the migration of type II endometrial cancer cells by activating SMAD (inducing SMAD 2/3 phosphorylation and knocking down SMAD4) and ERK 1/2, which down-regulates PTEN

7. overview of primary cilia-mediated regulation of receptor tyrosine kinase (show RET Proteins) (RTK- PDGFRa (show PDGFRA Proteins) and PDGFRb (show PDGFRB Proteins)) and transforming growth factor beta (TGF-beta) signaling [review]

8. The present study indicates that TGFB1 variants have subtype-specific roles in BC and may switch from tumor suppressor to promoter during tumor development, consistent with TGFbeta1 dual role in BC pathogenesis.

9. the expression of TGF-beta1 was related to shorter survival time and rapid progression for gastric cancer patients

10. Results suggest that high TGF-beta1 expression promotes a poor prognosis in hepatocellular carcinoma patients. [meta-analysis]

Pig (Porcine) Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. Activated TGF-beta signaling rescued miR (show MYLIP Proteins)-143-reduced FSHR (show FSHR Proteins) and intracellular signaling molecules, and miR (show MYLIP Proteins)-143-induced porcine granulosa cell apoptosis.

2. TGF-beta1-induced epithelial-myofibroblast plasticity is FAK (show PTK2 Proteins)- dependent, whereas TGF-beta1-induced apoptosis is favored when FAK (show PTK2 Proteins) signaling is inhibited.

3. this study shows that TGF-beta1 protects intestinal integrity and influences Smad (show SMAD1 Proteins) and MAPK (show MAPK1 Proteins) signal pathways in intestinal epithelium cells after TNF-alpha (show TNF Proteins) challenge

4. this study shows that anemonin may ameliorate LPS (show IRF6 Proteins)-induced intestinal injury and improve restoration by regulating the TGF-b1 and EGFR (show EGFR Proteins) signaling pathways

5. The results indicated that TGF-beta-1 was associated with the restoration of intestinal morphology and barrier function following weaning stress.

6. Data (including data from in vitro and in vivo experiments) suggest that day 14 elongated conceptus secretes proteins that up-regulate TGFbeta1 mRNA and TGFbeta1 expression in endometrium; TGFbeta1 may be important during pregnancy maintenance.

7. The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1, IL-10 (show IL10 Proteins), and IL-6 (show IL6 Proteins) in ovarian follicles are reported.

8. Dietary (1,3/1,6)-beta-D-glucan reduced the mRNA expression of transforming growth factor (TGF) beta2 (show TGFB2 Proteins) and tended to reduce the mRNA expression of TGF-beta1 in lung tissue of neonatal piglet.

9. TGF-beta1, via TGF-beta1 receptor I and p38 MAPK (show MAPK14 Proteins) signaling, reduces CFTR (show CFTR Proteins) expression to impair CFTR (show CFTR Proteins)-mediated anion secretion, which would likely compound the effects associated with mild CFTR (show CFTR Proteins) mutations and ultimately would compromise male fertility.

10. High yield isolation of BMP-2 (show BMP2 Proteins) from bone and in vivo activity of a combination of BMP-2 (show BMP2 Proteins)/TGF-beta1.

Cow (Bovine) Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. TGF-beta1 stimulated lubricin (show PRG4 Proteins) secretion by superficial zone chondrocytes at all densities with twice-a-week TGF-beta treatment. It is noteworthy that the daily treatment of TGF-beta1 increased lubricin (show PRG4 Proteins) much higher compared with twice-a-week treatment.

2. hypoxia increased the expression of platelet-derived growth factor (PDGF (show PDGFA Proteins)) and transforming growth factor-beta1 (TGF-beta1) and decreased the expression of neprilysin (NEP (show MME Proteins)), which contributed to the hypoxia-induced Endothelial-to-mesenchymal transition of pulmonary artery endothelial cells.

3. TGF-beta1 modulates the expression of syndecan-4 (show SDC4 Proteins) in cultured vascular endothelial cells in a biphasic manner.

4. Taken together, Staphylococcus aureus induces TGF-beta1 and bFGF (show FGF2 Proteins) expression through the activation of AP-1 (show JUN Proteins) and NF-kappaB (show NFKB1 Proteins) in bovine mammary gland fibroblasts.

5. The results identify TGFB1 and ESRRA (show ESRRA Proteins) as likely transcriptional regulators of rumen epithelial development and energy metabolism, respectively, and provide targets for modulation of rumen development and function in the growing calf.

6. the combined treatment with TGF-beta1 and BMP-7 (show BMP7 Proteins) or treatment first with TGF-beta1 followed by BMP-7 (show BMP7 Proteins) was more effective than other treatment groups in both chondrogenic differentiation and SZP (show PRG4 Proteins) secretion.

7. Tenascin-X (show TNXB Proteins) promotes activation of latent TGF-beta1 and subsequent epithelial to mesenchymal transition in mammary epithelial cells.

8. a detailed computational model for TGF-beta signalling that incorporates elements of previous models together with crosstalking between Smad1 (show SMAD1 Proteins)/5/8 and Smad2 (show SMAD2 Proteins)/3 channels through a negative feedback loop dependent on Smad7 (show SMAD7 Proteins).

9. Endogenous TGF-beta1 became more bioactive following activation of the transgene protein product in chondrocytes.

10. A novel peptide, P2K, regulating TGF-beta1 signaling had an anabolic effect on bovine intervertebral disc cells and rabbit degenerated discs.

Mouse (Murine) Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. These data suggest that the interplay between cell-matrix adhesion and intercellular adhesion is an important determinant for some aspects of TGFbeta1-induced epithelial-mesenchymal transition via alphaSMA (show ACTA2 Proteins) expression induction.

2. Excessive activation of TGFbeta by spinal instability causes vertebral endplate sclerosis and intervertebral disk degeneration.

3. study reveals a critical mechanism by which TGFbeta controls TH17 cell differentiation and uncovers the SKI (show SKI Proteins)-SMAD4 (show SMAD4 Proteins) axis as a potential therapeutic target for treating TH17-related diseases

4. A Smad3 (show SMAD3 Proteins)-PTEN regulatory loop controls proliferation and apoptotic responses to TGF-beta in mouse endometrium.

5. TGFss through the Alk1 (show ACVRL1 Proteins)/TgfssR2 receptor axis is acting on endothelial cells to produce hematopoiesis.

6. The adoptive transfer of NK1.1(-) CD4 (show CD4 Proteins)(+) NKG2D (show KLRK1 Proteins)(+) cells suppressed DSS (show PMP22 Proteins)-induced colitis largely dependent on TGF-beta. Thus, NK1.1(-) CD4 (show CD4 Proteins)(+) NKG2D (show KLRK1 Proteins)(+) cells exhibited immune regulatory functions, and this T cell subset could be developed to suppress inflammation in clinics.

7. The present study describes the ability of color-coded intravital imaging to demonstrate the efficacy of a TGF-beta inhibitor to target stroma in an orthotopic mouse model of pancreatic cancer.The present study describes the ability of color-coded intravital imaging to demonstrate the efficacy of a TGF-beta inhibitor to target stroma in an orthotopic mouse model of pancreatic cancer.

8. The ratio of full-length versus cleaved uPAR (show PLAUR Proteins) as analysed by Western blotting and its regulation was assessed by addition of different protease inhibitors and transforming growth factor - beta1 (TGF-beta1). The role of uPAR (show PLAUR Proteins) cleavage in cell proliferation and migration was analysed using real-time cell analysis and invasion was assessed using the myoma invasion model

9. Hepatic Stellate Cells express iron-transport proteins. Holotransferrin (iron) activates HSC (show FUT1 Proteins) fibrogenesis and the TGF-beta pathway, whereas iron depletion by chelation reverses this, suggesting that this could be a useful adjunct therapy for patients with fibrosis.

10. The results show that lnc-Spry1 (show SPRY1 Proteins) could act as an early mediator of TGF-beta signaling and reveal different roles for a long noncoding RNA in modulating transcriptional and posttranscriptional gene expression.

Rabbit Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. Data indicate that cardiac contractility modulation (CCM) therapy exerted protective effects against myocardial fibrosis potentially by inhibiting TGF-beta1/Smad3 (show SMAD3 Proteins) signaling pathway in chronic heart failure .

2. study suggested that TGF-beta1/Smad3/smad7 is a major pathway which plays an important role in the regulation of the IUA and specific inhibitor of Smad3 (SIS3) may provide a new therapeutic strategy for IUA.

3. cell therapy promoted TGF-beta1 expression in nucleus pulposus, leading to anti-inflammatory effects via the inhibition of NF-kappaB (show NFKB1 Proteins), and the amelioration of disc degradation.

4. that prenatal tracheal occlusion increases TGF-beta/Rho kinase (show ROCK1 Proteins) pathway, myofibroblast differentiation, and matrix deposition in neonatal rabbit and human congenital diaphragmatic hernia lungs

5. observation. Based on the above results, we conclude that TGF-beta1-immobilized PLGA-gelatin scaffold seeded with ASCs considerably enhances the quality of the tissue-engineered cartilage, therefore, advancing the field of cartilage tissue engineering

6. Smad7 (show SMAD7 Proteins) plays a crucial role in antagonizing epithelial-mesenchymal transition induced by TGFbeta signaling and is a Notch (show NOTCH1 Proteins) signaling target in limbal epithelial stem cells.

7. the role of IL-10 in inhibited allograft rejection may be associated with CD4+CD25+ regulatory T cells and IL-10, and may be independent of TGF-b

8. After NOTCH1 (show NOTCH1 Proteins) knockdown and TGFB1 stimulation, rabbit mesenchymal stem cells expressed higher levels of proteoglycan (show Vcan Proteins) and collagen II.

9. TGF-beta1 gene transcription significantly correlates with the surgical vaginal and dermal wound closure rate.

10. A novel peptide, P2K, regulating TGF-beta1 signaling had an anabolic effect on bovine intervertebral disc cells and rabbit degenerated discs.

Guinea Pig Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. TGF beta is involved in the pathogenesis of tympanosclerosis.

2. There was significantly higher expression of TGF-beta1 and MMP-9 (show MMP9 Proteins) in nasal mucosa of experimental allergic rhinitis guinea pigs than in controls.

Horse (Equine) Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. Within the limitations of the study design, production of COMP (show COMP Proteins) during healing of skin wounds does not appear to be influenced by wound type or anatomic site, nor does it appear to be correlated with TGF-beta1 concentrations.

2. Peritoneal TGF-beta(1) concentration was higher in horses with severe gastrointestinal diseases, in horses with an altered peritoneal fluid, and in nonsurvivors.