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Human Polyclonal CXXC1 Primary Antibody for WB - ABIN537359
Ansari, Mishra, Mandal: Human CpG binding protein interacts with MLL1, MLL2 and hSet1 and regulates Hox gene expression. in Biochimica et biophysica acta 2008
These results suggest that LWS-activating region (LAR) regulates both LWS-1 and LWS-2 by enhancing their expression and that interaction of LAR with the promoters is competitive between the two genes in a developmentally restricted manner.
CFP1 has an important role during postgastrulation development
Results demonstrate that CXXC1 is not an essential link between PRDM9-activated recombination hotspot sites and DSB machinery and that the hotspot recognition pathway in mouse is independent of CXXC1.
Data indicate that CXXC finger protein 1 (Cfp1) is necessary for hematopoietic stem and multi-potential progenitor cell function and for the developmental potential of differentiating hematopoietic cells.
NF-kappaB recruitment enhanced the occupancy of the CpG island within the 14-3-3gamma promoter by CFP1.14-3-3gamma induction in CSR is enabled by the CFP1-mediated H3K4me3 enrichment in the promoter, dependent on NF-kappaB and sustained by E2A.
The results demonstrated that Cfp1 is a specificity factor that integrates multiple signals, including promoter CpG content and gene activity, to regulate genome-wide patterns of H3K4me3.
a primary function of non-methylated CpG islands is to genetically influence the local chromatin modification state by interaction with Cfp1 and perhaps other CpG-binding proteins
embryonic stem cells lacking Cfp1 (CXXC1(-/-)) are viable but show increased levels of global histone H3K4 methylation, suggesting that Cfp1 functions to inhibit or restrict the activity of the Setd1A histone H3K4 methyltransferase complex.
findings show that CGBP is essential for normal epigenetic modification of the genome by cytosine methylation and for cellular differentiation, consistent with the requirement for CGBP during early mammalian development
expression of either the amino half of Cfp1 (amino acids 1 to 367 [Cfp1(1-367)]) or the carboxyl half of Cfp1 (Cfp1(361-656)) is sufficient to correct all of the defects observed with embryonic stem cells that lack Cfp1
CFP1 binds open chromatin regions of active genes, including enhancers and non-CpG islands.
directly controls the expression of key genes important for thymocyte survival, such as RORgammat, and for T-cell receptor signaling, including Zap70 and CD8, through maintaining the appropriate H3K4me3 on their promoters
The crescent-shaped CFP1 CXXC domain is wedged into the major groove of the CpG DNA, distorting the B-form DNA, and interacts extensively with the major groove of the DNA.
CXXC finger protein 1 is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex
CXXC finger protein 1 is required for normal proliferation and differentiation of the PLB-985 myeloid cell line.
CGBP interacts with MLL1, MLL2 as well as Set1 H3-Lysine 4 (H3K4) specific methyl-transferases and plays critical roles in regulations of MLL target genes.
study shows endogenous DNMT1 & CFP1 interact in vivo; CFP1 interaction with Setd1A or Setd1B not required for its interaction with DNMT1; result indicates CFP1 intersects cytosine methylation machinery independently of its association with Setd1 complexes
Proteins that contain a CXXC motif within their DNA-binding domain, such as CXXC1, recognize CpG sequences and regulate gene expression (Carlone and Skalnik, 2001
cpg binding protein
, CXXC finger protein 1
, cpG-binding protein-like
, CXXC finger 1 (PHD domain)
, CXXC-type zinc finger protein 1
, CpG binding protein
, PHD finger and CXXC domain-containing protein 1
, cpG-binding protein
, DNA-binding protein with PHD finger and CXXC domain
, zinc finger, CpG binding-type containing 1