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Human Polyclonal CXXC1 Primary Antibody for WB - ABIN537359
Ansari, Mishra, Mandal: Human CpG binding protein interacts with MLL1, MLL2 and hSet1 and regulates Hox gene expression. in Biochimica et biophysica acta 2008
These results suggest that LWS-activating region (LAR (show PTPRF Antibodies)) regulates both LWS-1 and LWS-2 by enhancing their expression and that interaction of LAR (show PTPRF Antibodies) with the promoters is competitive between the two genes in a developmentally restricted manner.
CFP1 has an important role during postgastrulation development
Data indicate that CXXC finger protein 1 (Cfp1) is necessary for hematopoietic stem and multi-potential progenitor cell function and for the developmental potential of differentiating hematopoietic cells.
NF-kappaB (show NFKB1 Antibodies) recruitment enhanced the occupancy of the CpG island within the 14-3-3gamma promoter by CFP1.14-3-3gamma induction in CSR (show SCARA3 Antibodies) is enabled by the CFP1-mediated H3K4me3 enrichment in the promoter, dependent on NF-kappaB (show NFKB1 Antibodies) and sustained by E2A (show TCF3 Antibodies).
The results demonstrated that Cfp1 is a specificity factor that integrates multiple signals, including promoter CpG content and gene activity, to regulate genome-wide patterns of H3K4me3.
a primary function of non-methylated CpG islands is to genetically influence the local chromatin modification state by interaction with Cfp1 and perhaps other CpG-binding proteins
embryonic stem cells lacking Cfp1 (CXXC1(-/-)) are viable but show increased levels of global histone H3K4 methylation, suggesting that Cfp1 functions to inhibit or restrict the activity of the Setd1A (show SETD1A Antibodies) histone H3K4 methyltransferase complex.
findings show that CGBP is essential for normal epigenetic modification of the genome by cytosine methylation and for cellular differentiation, consistent with the requirement for CGBP during early mammalian development
expression of either the amino half of Cfp1 (amino acids 1 to 367 [Cfp1(1-367)]) or the carboxyl half of Cfp1 (Cfp1(361-656)) is sufficient to correct all of the defects observed with embryonic stem cells that lack Cfp1
directly controls the expression of key genes important for thymocyte survival, such as RORgammat, and for T-cell receptor signaling, including Zap70 (show ZAP70 Antibodies) and CD8 (show CD8A Antibodies), through maintaining the appropriate H3K4me3 on their promoters
NF-kappaB (show NFKB1 Antibodies) recruitment enhanced the occupancy of the CpG island within the 14-3-3gamma promoter by CFP1.14-3-3gamma induction in CSR (show MORF4 Antibodies) is enabled by the CFP1-mediated H3K4me3 enrichment in the promoter, dependent on NF-kappaB (show NFKB1 Antibodies) and sustained by E2A (show TCF3 Antibodies).
The crescent (show SFRP5 Antibodies)-shaped CFP1 CXXC domain is wedged into the major groove of the CpG DNA, distorting the B-form DNA, and interacts extensively with the major groove of the DNA.
CXXC finger protein 1 is a component of the mammalian Set1 (show SETD1A Antibodies) histone H3 (show HIST3H3 Antibodies)-Lys4 methyltransferase complex
CXXC finger protein 1 is required for normal proliferation and differentiation of the PLB (show PLN Antibodies)-985 myeloid cell line.
CGBP interacts with MLL1, MLL2 (show MLL2 Antibodies) as well as Set1 (show SETD1A Antibodies) H3-Lysine 4 (H3K4) specific methyl-transferases and plays critical roles in regulations of MLL (show MLL Antibodies) target genes.
study shows endogenous DNMT1 (show DNMT1 Antibodies) & CFP1 interact in vivo; CFP1 interaction with Setd1A (show SETD1A Antibodies) or Setd1B (show SETD1B Antibodies) not required for its interaction with DNMT1 (show DNMT1 Antibodies); result indicates CFP1 intersects cytosine methylation machinery independently of its association with Setd1 complexes
Proteins that contain a CXXC motif within their DNA-binding domain, such as CXXC1, recognize CpG sequences and regulate gene expression (Carlone and Skalnik, 2001
cpg binding protein
, CXXC finger protein 1
, cpG-binding protein-like
, CXXC finger 1 (PHD domain)
, CXXC-type zinc finger protein 1
, CpG binding protein
, PHD finger and CXXC domain-containing protein 1
, cpG-binding protein
, DNA-binding protein with PHD finger and CXXC domain
, zinc finger, CpG binding-type containing 1