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The derlin-1 pathway therefore may represent a significant early checkpoint in the recognition and degradation of ENaC (show SCNN1A Proteins) in mammalian cells.
Cav-1 (show CAV1 Proteins) may be a cofactor in the interaction of Derlin-1 and N-glycosylated COX-2 and may facilitate Derlin-1- and p97 (show EIF4G2 Proteins) complex-mediated COX-2 ubiquitination, retrotranslocation, and degradation.
Derlin-1 deficiency is embryonic lethal, Derlin-3 (show DERL3 Proteins) deficiency appears normal, and Herp (show HERPUD1 Proteins) deficiency is intolerant to glucose load and ischemia in mice
Derlin-1 regulates the turnover of superoxide dismutase 1 (show SOD1 Proteins) by promoting the proteasomal and autophagosomal degradation of SOD1 (show SOD1 Proteins) protein, but not by decreasing mutant SOD1 (show SOD1 Proteins) mRNA levels.
Perturbation of binding between SOD1 (show SOD1 Proteins)(mut (show MUT Proteins)) and Derlin-1 by Derlin-1-derived oligopeptide suppressed SOD1 (show SOD1 Proteins)(mut (show MUT Proteins))-induced ER stress, ASK1 (show MAP3K5 Proteins) activation, and motor neuron death.
These findings for the first time revealed that miR (show MLXIP Proteins)-598, as a tumor suppressor, negatively regulate DERL1 and Epithelial-Mesenchymal Transition to suppress the invasion and migration in Non-Small Cell Lung Cancer (NSCLC), thereby putatively serving as a novel therapeutic target for NSCLC clinical treatment.
ChIP assays were used to ascertain the correlations between HNF1beta (show HNF1B Proteins) and Derlin-1 in the miR (show MLXIP Proteins)-217/HNF1beta (show HNF1B Proteins)/Derlin-1 pathway in glioma cells
Derlin-1 is overexpressed in bladder cancer and promotes malignant phenotype through ERK (show EPHB2 Proteins)/MMP-2 (show MMP2 Proteins)/9 and PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) signaling pathway.
Derlin-1 was overexpressed in bladder cancer and was associated with the malignancy of bladder cancer.
insights into the interactions between other SHP (show LAMC1 Proteins)-containing proteins and p97N
data suggest that miR (show MLXIP Proteins)-181d is a tumor suppressor in ESCC inversely regulating its downstream target gene of DERL1.
Results showed that Derlin-1 is overexpressed in colon cancer and promotes proliferation of colon cancer cells.
TMEM129 contains an unusual cysteine-only RING with intrinsic E3 ligase activity and is recruited to US11 via Derlin-1.
A role for DERL1 in tissue remodeling events and maintenance of function in reproductive tissues.
The protein encoded by this gene is a member of the derlin family. Members of this family participate in the ER-associated degradation response and retrotranslocate misfolded or unfolded proteins from the ER lumen to the cytosol for proteasomal degradation. This protein recognizes substrate in the ER and works in a complex to retrotranslocate it across the ER membrane into the cytosol. This protein may select cystic fibrosis transmembrane conductance regulator protein (CFTR) for degradation as well as unfolded proteins in Alzheimer's disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
, Dm Derlin-1
, Der1-like domain family, member 1
, Der1-like protein 1
, degradation in endoplasmic reticulum protein 1
, der1-like protein 1