Browse our anti-NRF2 (NFE2L2) Antibodies

Zebrafish Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) interaction partners

1. Nrf2a-deficient zebrafish showed higher susceptibility to oxidative stress, and higher vulnerability to acetaminophen- or doxorubicin-induced toxicity.

2. by performing protein profiling on isolated astrocytes we showed that an increase in astrocytic DJ-1 expression up-regulated a large group of proteins associated with redox regulation, inflammation and mitochondrial respiration. The majority of these proteins have also been shown to be regulated by Nrf2.

3. Nrf2 was activated in response to the ER stress via the PERK pathway.

4. Knockdown of Nrf2 paralogs perturbed glutathione redox state in zebrafish embryo. Nrf2 alone is not essential for the response and recovery of glutathione to oxidative insults.

5. nrf2a modulates the embryonic response to perfluorooctanesulfonic acid (PFOS), and that PPAR signaling may play a role in the embryonic adaptive response to PFOS.

6. These results suggest that alpha,beta-unsaturated carbonyl entity and catechol moiety of 6S derivatives may react with the cysteine residues of Keap1, disrupting the Keap1-Nrf2 complex, thereby liberating and activating Nrf2. Our findings of natural product-derived Nrf2 activators lead to design options of potent Nrf2 activators for further optimization.

7. These data suggest that EC from the Tripterygium wilfordii stem extract could diminish tau-GFP-induced neuronal death through the activation of Nrf2.

8. we concluded that Nrf2 plays a fundamental and conserved role in protection against acute sodium arsenite toxicity

9. Coptisine exerted its antioxidant activity against AAPH-induced toxicity involving in activating Akt and JNK/Nrf2/NQO1 pathway.

10. Bach1 regulates the liver specificity and transience of the Nrf2a-dependent induction of hmox1a and that heme mediates this regulation through Bach1 inhibition based on its level in each tissue.

11. The Bach1b-MafK heterodimer represses the zymogen promoters, whereas the Nrf2a-MafK heterodimer activates them.

12. The expression of nrf genes varies temporally throughout development and nrf genes are induced following a pro-oxidant exposure and are potentially cross-regulated by gene family members Nrf2a and Nrf2b.

13. oxidative stress is an important mechanism of Cd-mediated injury in the zebrafish olfactory system; the Nrf2 pathway plays a protective role against cellular oxidative damage and is important in maintaining zebrafish olfactory function.

14. results revealed that nrf2 mutant zebrafish are viable and fertile but show an increased susceptibility to oxidative stress and electrophiles

15. compared the tissue-specific expression of several Nrf2 target genes in zebrafish larvae; Tissue-restricted induction was observed in the nose, gill, and/or liver for seven genes in response to Nrf2-activating compounds

16. Nrf2 is protective against PFOS-induced oxidative stress in zebrafish larvae.

17. mutation of either residual cysteine residue in Keap1a and Keap1b disrupted the ability of Keap1 to repress Nrf2, indicating that the presence of either Cys-273 or Cys-288 is sufficient for fish Keap1 molecules to fully function

18. study reports that the Keap1-Nrf2 system comprises discrete sensor sites, including the Keap1 cysteines Cys-151 and Cys-273, for a variety of Nrf2-activating compounds

19. findings demonstrate that antioxidant responses are a component of polycyclic aromatic hydrocarbon (PAH)synergistic developmental toxicity and that NRF2 is protective against prooxidant and PAH challenges during development

Cow (Bovine) Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) interaction partners

1. this study highlighted the involvement of miR-153, miR-28 and miR-708 in regulatory network of Nrf2 mediated antioxidant system in bovine granulosa cells function.

2. These findings suggest that bronchiolar epithelial cells and macrophages up-regulate Nrf2 expression early in the course of infection, which results in increased expression of HO-1 within these cells.

3. the survival and developmental competence of embryos cultured under oxidative stress are associated with activity of the NRF2-mediated oxidative stress response pathway during bovine pre-implantation embryo development.

4. expression of target genes in liver in transition period and stages of lactation

5. investigation of molecular mechanisms of microvascular complications in diabetes/hyperglycemia: Nrf2 is involved in regulation of HO-1 gene expression in aortic endothelial cells by advanced glycation end products

Pig (Porcine) Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) interaction partners

1. The results of the current study indicate that dioscin may protect against coronary heart disease by regulating oxidative stress and inflammation via Sirt1/Nrf2 and p38 MAPK pathways.

2. Lack of Nrf2 enhances susceptibility to mycotoxin-induced kidney disease.

3. The effects of ochratoxin A on the nuclear translocation and transactivation of the transcription factor Nrf2 as well as mRNA levels of Nrf2 target genes are reported.

Human Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) interaction partners

1. miR-155 mediated arsenic trioxide resistance by upregulating the Nrf2 signaling pathway, but downregulating cellular apoptosis in lung cancer cells.

2. Metabolic reprogramming to glutathione metabolism, and ROS detoxification by activation of Nrf2, enhanced cancer progression and led to a poor clinical outcome in oesophageal cancer patients.

3. to differences in relative orientation within this complex. The observed CGA isomer-specific affinity for CQA to activate Nrf2 signaling was confirmed by nuclear translocation of Nrf2 induced by CGA and greater (p < 0.05) upregulation of genes related to Nrf2 expression.

4. NRF2 regulates endothelial glycolysis and proliferation with miR-93 and mediates the effects of oxidized phospholipids on endothelial activation.

5. In vitro experiments on colonic epithelial cells showed that stable SMP30 expression inhibited but that SMP30 siRNA expression increased TNF-alpha-induced apoptosis. SMP30 inhibition decreased Nrf2 mRNA expression levels (p<0.0001), but SMP30 overexpression increased Nrf2 mRNA expression levels (p=0.0495).

6. we show that Triclosan (TCS) induces toxicity in both the nematode C. elegans and human mesenchymal stem cells (hMSCs) by disrupting the SKN-1/Nrf2-mediated oxidative stress response. Specifically, TCS exposure affected C. elegans survival and hMSC proliferation in a dose-dependent manner.

7. Nrf2 signaling via its antioxidant activity has a critical and previously undescribed role of protecting cells during glucose deprivation-induced autophagy

8. activating Nrf2 antioxidant pathway suppresses Epithelial mesenchymal transition during pulmonary fibrosis via inhibiting the abnormal expression of Numb.

9. Studied role of Physalin A as an antineoplastic agent in activation of nuclear factor erythroid 2 (Nrf2) and p38 pathway and subsequent increase in quinone reductase expression.

10. Igalan activated the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway by increasing the inactive form of GSK3beta, the phosphorylated form of AKT, and the nuclear accumulation of Nrf2. Thus, target genes of Nrf2 such as HO-1 and NQO1 increased in HepG2 cells.

11. Nfr2 and Bach1 expression are altered in colorectal carcinoma but in different ways

12. These findings suggest that NRF2 and HSF1 have opposing roles during autophagy, and illustrate the existence of tight mechanistic links between the cellular stress responses.

13. Studied function of nuclear factor erythroid 2 like 2 (Nrf2) signaling in diabetes mellitus type 2, its activation by natural products, and the possible amelioration of insulin resistance, beta-cell dysfunction and diabetic complications by activated Nrf2.

14. NF-E2-related factor 2 (NRF2) directly controls TRPA1 Cation Channel (TRPA1) expression, providing an orthogonal mechanism for protection against oxidative stress together with canonical reactive oxygen species (ROS)-neutralizing mechanisms.

15. Data indicate that kelch-Like ECH-associated protein 1 (KEAP1)/nuclear factor (erythroid-derived 2)-like 2 protein (NRF2)-mutant lung cancer is a microenvironmentally distinct, biologically heterogeneous, and clinically underestimated disease.

16. Isoliquiritigenin alleviated the Ang II-induced hypertensive renal injury through suppressing inflammation cytokines, excessive deposition of extracellular matrix and oxidative stress-induced apoptosis via Nrf2 and NF-kappaB pathways.

17. The role of Nrf2 transcription factor in viral infection.

18. the role of Nrf2 in the cancer cell

19. this study shows that crosstalk between Nrf2 and YAP contributes to maintaining the antioxidant potential and chemoresistance in bladder cancer

20. Nrf2 may act as a signaling mediator for the mitochondria function following PM2.5 exposure.

Mouse (Murine) Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) interaction partners

1. Silencing Keap1 was able to reverse the inhibitory effect of Axitinib and enhance the protein expressions of Nrf2, NAD(P)H dehydrogenase [quinone] 1 and heme oxygenase 1.

2. Study results suggest that Nrf2 is a critical regulator of innate, inflammatory, and disease-associated responses in the airways of mice infected with viruses that are members of the Pneumoviridae family. Nrf2-dependent genes, including those controlling the cellular antioxidant and H2S-generating enzymes and cytokines can affect several aspects of the antiviral response.

3. Nrf2 regulates CD4(+) T cell-induced acute graft-versus-host disease in mice.

4. Together these data indicate that NRF2 and clock comprise an interlocking loop that integrates cellular redox signals into tissue-specific circadian timekeeping.

5. in different target tissues and rather suggests systemic activation of the Nrf2 pathway as an effective means of prevention and treatment of obesity and type 2 diabetes

6. The underlying mechanism by which SMP30 protected cells appeared to be by inhibiting Nrf2 ubiquitination and Keap1 expression, and thus enhancing Nrf2 activity.

7. These results provide new insights into sulforaphane-induced upregulation of Nrf2 and its role in improving exercise performance.

8. Polydatin(PD) also targets Nrf2/HO-1 pathway to inhibit mast cell-derived allergic inflammatory reactions. In conclusion, the study demonstrates that PD is a possible therapeutic candidate for allergic inflammatory diseases.

9. Our findings reveal that Nrf2 may play a critical role in ameliorating Oxaliplatin-induced peripheral neuropathy, through protection of mitochondrial function by alleviating oxidative stress

10. activating Nrf2 antioxidant pathway suppresses Epithelial mesenchymal transition during pulmonary fibrosis via inhibiting the abnormal expression of Numb.

11. Nrf2 pathway is one of the most critical endogenous defense systems and regulates the anti-oxidant and anti-inflammatory cellular responses in the body.

12. MiR3405p serves a role in the posttranscriptional regulation of Nrf2 expression.

13. The intranasal EPOexerted neuroprotection was almost abolished when the specific Nrf2 antagonist ATRA was administered intraperitoneally prior to intranasal EPO treatment.

14. Decreasing malondialdehyde levels via nuclear factor (erythroidderived 2)like 2 protein/BTB and CNC homology 1 mediated antioxidant effect.

15. these results emphasize the importance of Nrf2 in dentate gyrus neural stem progenitor cell regeneration.

16. The results suggest that HSF1 and NRF2 suppress heme-induced and heat-induced HO-1 expression, respectively.

17. IL-18BP possessed protective effect against LPS-induced ALI, which might be associated with its regulation of NF-kappaB and Nrf2 activities.

18. Nrf2 exerts pleiotropic roles in the thyroid gland to couple cell stress defense mechanisms to iodide metabolism and the thyroid hormone synthesis machinery, both under basal conditions and in response to excess iodide

19. Keap1 possesses a Zn(2+) sensor whose triggering distorts its structure in a fashion that inhibits ubiquitylation of Nrf2 upon CRL(Keap1).

20. This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals.