Browse our anti-NRF2 (NFE2L2) Antibodies

Zebrafish Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) interaction partners

1. Nrf2a-deficient zebrafish showed higher susceptibility to oxidative stress, and higher vulnerability to acetaminophen- or doxorubicin-induced toxicity.

2. by performing protein profiling on isolated astrocytes we showed that an increase in astrocytic DJ-1 expression up-regulated a large group of proteins associated with redox regulation, inflammation and mitochondrial respiration. The majority of these proteins have also been shown to be regulated by Nrf2.

3. Nrf2 was activated in response to the ER stress via the PERK pathway.

4. Knockdown of Nrf2 paralogs perturbed glutathione redox state in zebrafish embryo. Nrf2 alone is not essential for the response and recovery of glutathione to oxidative insults.

5. nrf2a modulates the embryonic response to perfluorooctanesulfonic acid (PFOS), and that PPAR signaling may play a role in the embryonic adaptive response to PFOS.

6. These results suggest that alpha,beta-unsaturated carbonyl entity and catechol moiety of 6S derivatives may react with the cysteine residues of Keap1, disrupting the Keap1-Nrf2 complex, thereby liberating and activating Nrf2. Our findings of natural product-derived Nrf2 activators lead to design options of potent Nrf2 activators for further optimization.

7. These data suggest that EC from the Tripterygium wilfordii stem extract could diminish tau-GFP-induced neuronal death through the activation of Nrf2.

8. we concluded that Nrf2 plays a fundamental and conserved role in protection against acute sodium arsenite toxicity

9. Coptisine exerted its antioxidant activity against AAPH-induced toxicity involving in activating Akt and JNK/Nrf2/NQO1 pathway.

10. Bach1 regulates the liver specificity and transience of the Nrf2a-dependent induction of hmox1a and that heme mediates this regulation through Bach1 inhibition based on its level in each tissue.

11. The Bach1b-MafK heterodimer represses the zymogen promoters, whereas the Nrf2a-MafK heterodimer activates them.

12. The expression of nrf genes varies temporally throughout development and nrf genes are induced following a pro-oxidant exposure and are potentially cross-regulated by gene family members Nrf2a and Nrf2b.

13. oxidative stress is an important mechanism of Cd-mediated injury in the zebrafish olfactory system; the Nrf2 pathway plays a protective role against cellular oxidative damage and is important in maintaining zebrafish olfactory function.

14. results revealed that nrf2 mutant zebrafish are viable and fertile but show an increased susceptibility to oxidative stress and electrophiles

15. compared the tissue-specific expression of several Nrf2 target genes in zebrafish larvae; Tissue-restricted induction was observed in the nose, gill, and/or liver for seven genes in response to Nrf2-activating compounds

16. Nrf2 is protective against PFOS-induced oxidative stress in zebrafish larvae.

17. mutation of either residual cysteine residue in Keap1a and Keap1b disrupted the ability of Keap1 to repress Nrf2, indicating that the presence of either Cys-273 or Cys-288 is sufficient for fish Keap1 molecules to fully function

18. study reports that the Keap1-Nrf2 system comprises discrete sensor sites, including the Keap1 cysteines Cys-151 and Cys-273, for a variety of Nrf2-activating compounds

19. findings demonstrate that antioxidant responses are a component of polycyclic aromatic hydrocarbon (PAH)synergistic developmental toxicity and that NRF2 is protective against prooxidant and PAH challenges during development

Cow (Bovine) Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) interaction partners

1. this study highlighted the involvement of miR-153, miR-28 and miR-708 in regulatory network of Nrf2 mediated antioxidant system in bovine granulosa cells function.

2. These findings suggest that bronchiolar epithelial cells and macrophages up-regulate Nrf2 expression early in the course of infection, which results in increased expression of HO-1 within these cells.

3. the survival and developmental competence of embryos cultured under oxidative stress are associated with activity of the NRF2-mediated oxidative stress response pathway during bovine pre-implantation embryo development.

4. expression of target genes in liver in transition period and stages of lactation

5. investigation of molecular mechanisms of microvascular complications in diabetes/hyperglycemia: Nrf2 is involved in regulation of HO-1 gene expression in aortic endothelial cells by advanced glycation end products

Pig (Porcine) Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) interaction partners

1. The results of the current study indicate that dioscin may protect against coronary heart disease by regulating oxidative stress and inflammation via Sirt1/Nrf2 and p38 MAPK pathways.

2. Lack of Nrf2 enhances susceptibility to mycotoxin-induced kidney disease.

3. The effects of ochratoxin A on the nuclear translocation and transactivation of the transcription factor Nrf2 as well as mRNA levels of Nrf2 target genes are reported.

Human Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) interaction partners

1. Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer.

2. study identifies Nrf2 plays a central role in skewing Th1 and Th2 dominance in the progression of diabetes.

3. Nrf2-IR was detected in the cytoplasm and nuclei of hair cells and supporting cells thorough the human cochlea and the vestibular sensory epithelia. Nrf2-IR decreases significantly the cochlea of older individuals, but no in disease specimens. Nrf2 expression may be a good candidate to prevent and or protect from hearing loss due to noise, exposure to ototoxic drugs and normal and pathological aging.

4. The ability of Nfr2 activation in preventing this effect.

5. Our results provide the first evidence that primary human mast cells (MCs) exhibit substantial Nrf2 activity, which can effectively suppress MC activation and degranulation induced by Substance P.

6. In vitro experiments in human bronchial epithelial cells demonstrated that Nrf2 activated by bixin contributes to tissue repair by alleviating oxidative stress, increasing proliferation and migration, decreasing apoptosis, which may be partially through modulating the expression of MMP9, TGFbeta1, and FN.

7. The Nrf2 signaling pathway in normal cells maintains the cellular environment, and genomic stability and acts a tumor suppressing gene.Nrf2 promotes tumor growth and enhances drug resistance in ovarian cancer.[review]

8. heat shock-generated ROS were involved in induction of cellular defense molecules Prxs, GSH and G6PD through Nrf2 activation.

9. These results highlight the critical role of Nrf2/antioxidant response elements in the maintenance of Down syndrome cell homeostasis.

10. Our results revealed a novel link between Mkp-1 and Nrf2 signaling pathways in protecting against colonic inflammation

11. This study reveals that miR-144 expression was upregulated, whereas NRF2 expression and glutathione levels were decreased in comparison with the untreated condition after miR mimic transfection, while the reduction of miR-144 expression contributed to the increased NRF2 expression and glutathione level compared with the untreated condition after miR inhibitor transfection.

12. Through activating the Nrf2/HO-1 signaling pathway.

13. Identified mutations in KEAP1 associated with Nrf2 overexpression in papillary thyroid carcinoma. Mutations favored disruption of inhibitory interaction Nrf2-Keap1 to enable increased antioxidant Nrf2 activity, possibly with prognostic consequences.

14. the involvement of astroglial Nrf2/system xc(-) pathway in the neurotoxicity induced by HIV-1 Tat protein, is reported.

15. Nrf2 expression was not correlated with prognosis in non-small cell lung cancer

16. Genomic data suggest that gene mutations and several other mechanisms result in NRF2 hyperactivation in human ESCC. As a consequence, NRF2(high) ESCC is more resistant to chemoradiotherapy and associated with poorer survival than NRF2(low) ESCC.

17. Low NRF2 expression is associated with the progression from acute tubular damage to chronic renal fibrosis following unilateral ureteral obstruction.

18. rs6726395 and rs77684420 polymorphisms associated with noise-induced hearing loss in a Chinese population

19. Data indicate that transcription factor transcription factor 7-like 1 (TCF7L1) could regulate antioxidant response in gastric cancer cells by regulating Keap1/NRF2 [Kelch-like ECH-associated protein 1/nuclear factor (erythroid-derived 2)-like 2] pathway.

20. miR-155 mediated arsenic trioxide resistance by upregulating the Nrf2 signaling pathway, but downregulating cellular apoptosis in lung cancer cells.

Mouse (Murine) Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) interaction partners

1. Oxidative Stress Induces an Interactive Decline in Wnt and Nrf2 Signaling in Degenerating Retinal Pigment Epithelium

2. The results from the in vivo study showed that bixin treatment attenuated the accumulation of inflammatory cells, decreased the levels of tissue apoptosis, and increase the ability of cell proliferation. Besides that, bixin also could regulate the expression of MMP9, TGFbeta1, and its downstream Fibronectin (FN), along with activation of Nrf2 signals

3. In mice, activation of the Nrf2 and SIRT1 signaling pathways ameliorated oxidative stress and mitochondrial dysfunction. Pharmacological targeting of Nrf2 signaling molecules may reduce the pathologic changes of aging in the kidney.

4. c-Src-mediated regulation of Nrf2 transcriptional activity, via PKCdelta activation.

5. These results highlight the critical role of Nrf2/antioxidant response elements in the maintenance of Down syndrome cell homeostasis.

6. Our results revealed a novel link between Mkp-1 and Nrf2 signaling pathways in protecting against colonic inflammation

7. NRF2 is required for both self-defense and sodium butyrate's protection against diabetes-induced aortic endothelial dysfunction. Other findings suggest that P300 mediates the transcriptional activation of Nrf2 by sodium butyrate

8. Collectively, Nrf2 dysfunction exacerbates the deleterious effects of obesity, compromising cerebromicrovascular and brain health by impairing neurovascular coupling mechanisms, BBB integrity and synaptic function and promoting neuroinflammation.

9. Sulforaphane-Enriched Broccoli Sprouts Pretreated by Pulsed Electric Fields Reduces Neuroinflammation and Ameliorates Scopolamine-Induced Amnesia in Mouse Brain through Its Antioxidant Ability via Nrf2-HO-1 Activation.

10. camel whey protein supplemented heat stress (HS) mice exhibited complete restoration of Bcl2, P53, Nrf2, and PPAR-gamma expressions; testicular Leydig cell distribution; significant higher levels of testosterone levels; and hence higher percentages of progressively motile sperm and lower percentages of immotile sperm as compared to HS mice.

11. Silencing Keap1 was able to reverse the inhibitory effect of Axitinib and enhance the protein expressions of Nrf2, NAD(P)H dehydrogenase [quinone] 1 and heme oxygenase 1.

12. Study results suggest that Nrf2 is a critical regulator of innate, inflammatory, and disease-associated responses in the airways of mice infected with viruses that are members of the Pneumoviridae family. Nrf2-dependent genes, including those controlling the cellular antioxidant and H2S-generating enzymes and cytokines can affect several aspects of the antiviral response.

13. Nrf2 regulates CD4(+) T cell-induced acute graft-versus-host disease in mice.

14. Together these data indicate that NRF2 and clock comprise an interlocking loop that integrates cellular redox signals into tissue-specific circadian timekeeping.

15. in different target tissues and rather suggests systemic activation of the Nrf2 pathway as an effective means of prevention and treatment of obesity and type 2 diabetes

16. The underlying mechanism by which SMP30 protected cells appeared to be by inhibiting Nrf2 ubiquitination and Keap1 expression, and thus enhancing Nrf2 activity.

17. These results provide new insights into sulforaphane-induced upregulation of Nrf2 and its role in improving exercise performance.

18. Polydatin(PD) also targets Nrf2/HO-1 pathway to inhibit mast cell-derived allergic inflammatory reactions. In conclusion, the study demonstrates that PD is a possible therapeutic candidate for allergic inflammatory diseases.

19. Our findings reveal that Nrf2 may play a critical role in ameliorating Oxaliplatin-induced peripheral neuropathy, through protection of mitochondrial function by alleviating oxidative stress

20. activating Nrf2 antioxidant pathway suppresses Epithelial mesenchymal transition during pulmonary fibrosis via inhibiting the abnormal expression of Numb.