Browse our anti-NRF2 (NFE2L2) Antibodies

Zebrafish Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) interaction partners

1. by performing protein profiling on isolated astrocytes we showed that an increase in astrocytic DJ-1 expression up-regulated a large group of proteins associated with redox regulation, inflammation and mitochondrial respiration. The majority of these proteins have also been shown to be regulated by Nrf2.

2. Nrf2 was activated in response to the ER stress via the PERK pathway.

3. Knockdown of Nrf2 paralogs perturbed glutathione redox state in zebrafish embryo. Nrf2 alone is not essential for the response and recovery of glutathione to oxidative insults.

4. nrf2a modulates the embryonic response to perfluorooctanesulfonic acid (PFOS), and that PPAR signaling may play a role in the embryonic adaptive response to PFOS.

5. These results suggest that alpha,beta-unsaturated carbonyl entity and catechol moiety of 6S derivatives may react with the cysteine residues of Keap1, disrupting the Keap1-Nrf2 complex, thereby liberating and activating Nrf2. Our findings of natural product-derived Nrf2 activators lead to design options of potent Nrf2 activators for further optimization.

6. These data suggest that EC from the Tripterygium wilfordii stem extract could diminish tau-GFP-induced neuronal death through the activation of Nrf2.

7. we concluded that Nrf2 plays a fundamental and conserved role in protection against acute sodium arsenite toxicity

8. Coptisine exerted its antioxidant activity against AAPH-induced toxicity involving in activating Akt and JNK/Nrf2/NQO1 pathway.

9. Bach1 regulates the liver specificity and transience of the Nrf2a-dependent induction of hmox1a and that heme mediates this regulation through Bach1 inhibition based on its level in each tissue.

10. The Bach1b-MafK heterodimer represses the zymogen promoters, whereas the Nrf2a-MafK heterodimer activates them.

11. The expression of nrf genes varies temporally throughout development and nrf genes are induced following a pro-oxidant exposure and are potentially cross-regulated by gene family members Nrf2a and Nrf2b.

12. oxidative stress is an important mechanism of Cd-mediated injury in the zebrafish olfactory system; the Nrf2 pathway plays a protective role against cellular oxidative damage and is important in maintaining zebrafish olfactory function.

13. results revealed that nrf2 mutant zebrafish are viable and fertile but show an increased susceptibility to oxidative stress and electrophiles

14. compared the tissue-specific expression of several Nrf2 target genes in zebrafish larvae; Tissue-restricted induction was observed in the nose, gill, and/or liver for seven genes in response to Nrf2-activating compounds

15. Nrf2 is protective against PFOS-induced oxidative stress in zebrafish larvae.

16. mutation of either residual cysteine residue in Keap1a and Keap1b disrupted the ability of Keap1 to repress Nrf2, indicating that the presence of either Cys-273 or Cys-288 is sufficient for fish Keap1 molecules to fully function

17. study reports that the Keap1-Nrf2 system comprises discrete sensor sites, including the Keap1 cysteines Cys-151 and Cys-273, for a variety of Nrf2-activating compounds

18. findings demonstrate that antioxidant responses are a component of polycyclic aromatic hydrocarbon (PAH)synergistic developmental toxicity and that NRF2 is protective against prooxidant and PAH challenges during development

Cow (Bovine) Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) interaction partners

1. These findings suggest that bronchiolar epithelial cells and macrophages up-regulate Nrf2 expression early in the course of infection, which results in increased expression of HO-1 within these cells.

2. the survival and developmental competence of embryos cultured under oxidative stress are associated with activity of the NRF2-mediated oxidative stress response pathway during bovine pre-implantation embryo development.

3. expression of target genes in liver in transition period and stages of lactation

4. investigation of molecular mechanisms of microvascular complications in diabetes/hyperglycemia: Nrf2 is involved in regulation of HO-1 gene expression in aortic endothelial cells by advanced glycation end products

Pig (Porcine) Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) interaction partners

1. The results of the current study indicate that dioscin may protect against coronary heart disease by regulating oxidative stress and inflammation via Sirt1/Nrf2 and p38 MAPK pathways.

2. Lack of Nrf2 enhances susceptibility to mycotoxin-induced kidney disease.

3. The effects of ochratoxin A on the nuclear translocation and transactivation of the transcription factor Nrf2 as well as mRNA levels of Nrf2 target genes are reported.

Human Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) interaction partners

1. NF-E2-related factor 2 (NRF2) directly controls TRPA1 Cation Channel (TRPA1) expression, providing an orthogonal mechanism for protection against oxidative stress together with canonical reactive oxygen species (ROS)-neutralizing mechanisms.

2. Data indicate that kelch-Like ECH-associated protein 1 (KEAP1)/nuclear factor (erythroid-derived 2)-like 2 protein (NRF2)-mutant lung cancer is a microenvironmentally distinct, biologically heterogeneous, and clinically underestimated disease.

3. Isoliquiritigenin alleviated the Ang II-induced hypertensive renal injury through suppressing inflammation cytokines, excessive deposition of extracellular matrix and oxidative stress-induced apoptosis via Nrf2 and NF-kappaB pathways.

4. The role of Nrf2 transcription factor in viral infection.

5. the role of Nrf2 in the cancer cell

6. this study shows that crosstalk between Nrf2 and YAP contributes to maintaining the antioxidant potential and chemoresistance in bladder cancer

7. Nrf2 may act as a signaling mediator for the mitochondria function following PM2.5 exposure.

8. Study describes a novel role of NRF2 in controlling cell cycle machinery by inhibiting Cyclin D1 throughout its stoichiometric inhibitors at the initial stage of mild oxidative stress.

9. This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters.

10. Nrf2 knockdown also inhibited the protective effects of EX-4 against lipid accumulation.

11. combination of lower PTX3 and Nrf2 immunohistochemical expression may be important in offering a better prognosis in gliomas, although the detailed mechanism is yet to be elucidated

12. women with both diabetes mellitus and obesity detrimentally alter placenta function in oxidative stress regulation, and the Nrf2/ARE (antioxidant responsive element) pathway is involved; this may increase metabolic disturbance susceptibility in their offspring

13. This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals.

14. Andrographolide simultaneously upregulated antioxidant defense through the p62-Nrf2 loop.

15. The genome-wide miRNA microarray and primary erythroid progenitor data support a miR-144/NRF2-mediated mechanism of gamma-globin gene regulation in sickle cell disease.

16. expression of Nrf2 was significantly higher in osteoarthritis cartilage compared to normal cartilage

17. the mechanistic basis of HSF1 gene regulation in cancer cells and provide molecular evidence supporting a direct interaction between HSF1 and NRF2

18. This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins.

19. Inactive cytoplasmic NRF2 was associated with improved survival in ovarian cancer patients. Silencing of NFE2L2 induced a higher mRNA expression of ESR1.

20. Low nuclear expression of Nrf1, high cytoplasmic expression of Nrf1, high nuclear expression of Nrf2 and low cytoplasmic expression of Keap1 are associated with adverse outcome in high-risk diffuse large B cell lymphomas treated with R-CHOEP.

Mouse (Murine) Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) interaction partners

1. these results emphasize the importance of Nrf2 in dentate gyrus neural stem progenitor cell regeneration.

2. The results suggest that HSF1 and NRF2 suppress heme-induced and heat-induced HO-1 expression, respectively.

3. IL-18BP possessed protective effect against LPS-induced ALI, which might be associated with its regulation of NF-kappaB and Nrf2 activities.

4. Nrf2 exerts pleiotropic roles in the thyroid gland to couple cell stress defense mechanisms to iodide metabolism and the thyroid hormone synthesis machinery, both under basal conditions and in response to excess iodide

5. Keap1 possesses a Zn(2+) sensor whose triggering distorts its structure in a fashion that inhibits ubiquitylation of Nrf2 upon CRL(Keap1).

6. This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals.

7. CORM A-1 reduces oxidative stress by upregulating Nrf2.

8. show that the kinases Mst1 and Mst2 (Mst1/2) sense ROS and maintain cellular redox balance by modulating the stability of antioxidant transcription factor Nrf2.

9. The up regulation of Nrf2 was probably implicated in decreasing inflammatory cytokine levels and counteracting oxidative stress induced by sepsis.

10. hyperactive Nrf2 causes metabolic reprogramming in the mouse esophagus through its transcriptional regulation of metabolic genes.

11. these novel findings suggest that the NRF-2/PGC-1alpha dKO mouse is a valuable model for investigating the role of proteasomal and autophagy clearance in the RPE and in the development of dry AMD.

12. Nrf2, PGC-1alpha and TFAM were upregulated to compromise mitochondrial dysfunction.

13. Results provide evidence that NRF2 and AhR cooperate to regulate numerous antioxidant gene expression in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

14. The results from this study suggest a novel function of miR-24-3p in protecting cardiomyocytes from ischemia/reperfusion injury by the activation of the Nrf2-Keap1 pathway.

15. MDM2 controls diabetic and non-diabetic renal antioxidant capacity via NRF2. NRF2 predominantly mediates MDM2's action on diabetic kidney disease. P53 is a key factor through which MDM2 activates NRF2 in diabetic kidney disease.

16. These findings demonstrate that BFT activates the Nrf2/ARE pathway and is a promising therapeutic agent for the treatment of diseases with tau pathology, such as Alzheimer's disease (AD), frontotemporal dementia and progressive supranuclear palsy.

17. A delicate and synergistical collaboration between YY1 and the master transcription factor NRF2 that functions to mobilize the cell's antioxidant machinery.

18. In conclusion, these results indicated that Nrf2 activation in response to hyperhomocysteinemia plays an important role in mediating homocysteine-suppressed lipolysis in adipocytes.

19. We have firstly evaluated in silico the genes belonging to the Nrf2/HO-1/CO pathway that are involved in the pathogenesis of autoimmune hepatitis (AIH). The data obtained from the in silico study demonstrate that a significant number of genes modulated in the liver of ConA-challenged mice belong to the Nrf2 pathway

20. Cold exposure induced cardiac injury by inhibiting the Nrf2-Keap1 signaling pathway.