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These results suggest that alpha,beta-unsaturated carbonyl entity and catechol moiety of 6S derivatives may react with the cysteine residues of Keap1 (show KEAP1 Proteins), disrupting the Keap1 (show KEAP1 Proteins)-Nrf2 complex, thereby liberating and activating Nrf2. Our findings of natural product-derived Nrf2 activators lead to design options of potent Nrf2 activators for further optimization.
These data suggest that EC from the Tripterygium wilfordii stem extract could diminish tau-GFP-induced neuronal death through the activation of Nrf2.
we concluded that Nrf2 plays a fundamental and conserved role in protection against acute sodium arsenite toxicity
Coptisine exerted its antioxidant activity against AAPH-induced toxicity involving in activating Akt (show AKT1 Proteins) and JNK (show MAPK8 Proteins)/Nrf2/NQO1 (show NQO1 Proteins) pathway.
Bach1 (show BACH1 Proteins) regulates the liver specificity and transience of the Nrf2a-dependent induction of hmox1a and that heme mediates this regulation through Bach1 (show BACH1 Proteins) inhibition based on its level in each tissue.
The Bach1b-MafK heterodimer represses the zymogen promoters, whereas the Nrf2a-MafK heterodimer activates them.
The expression of nrf genes varies temporally throughout development and nrf genes are induced following a pro-oxidant exposure and are potentially cross-regulated by gene family members Nrf2a and Nrf2b.
oxidative stress is an important mechanism of Cd-mediated injury in the zebrafish olfactory system; the Nrf2 pathway plays a protective role against cellular oxidative damage and is important in maintaining zebrafish olfactory function.
results revealed that nrf2 mutant zebrafish are viable and fertile but show an increased susceptibility to oxidative stress and electrophiles
compared the tissue-specific expression of several Nrf2 target genes in zebrafish larvae; Tissue-restricted induction was observed in the nose, gill, and/or liver for seven genes in response to Nrf2-activating compounds
These findings suggest that bronchiolar epithelial cells and macrophages up-regulate Nrf2 expression early in the course of infection, which results in increased expression of HO-1 (show HMOX1 Proteins) within these cells.
the survival and developmental competence of embryos cultured under oxidative stress are associated with activity of the NRF2-mediated oxidative stress response pathway during bovine pre-implantation embryo development.
investigation of molecular mechanisms of microvascular complications in diabetes/hyperglycemia: Nrf2 is involved in regulation of HO-1 (show HMOX1 Proteins) gene expression in aortic endothelial cells by advanced glycation end products
Lack of Nrf2 enhances susceptibility to mycotoxin-induced kidney disease.
The effects of ochratoxin A on the nuclear translocation and transactivation of the transcription factor Nrf2 as well as mRNA levels of Nrf2 target genes are reported.
Results provide evidence that mtROS-induced decline in NFE2L2 activity is a key event in continuous presentation of antioxidant/oxidant imbalance, cardiac hypertrophy, and left ventricle (LV) systolic and diastolic dysfunction in chagasic myocardium.
Nrf2 (show GABPA Proteins) alleviates PDLSCs via its effects on regulating oxidative stress and anti-intrinsic apoptosis by the activation of oxidative enzymes.
Our findings indicate that NRF2 (show GABPA Proteins) silencing-mediated reduction of RhoA (show RHOA Proteins) expression contributes, at least in part, to the poor outcome of breast cancer patients with high NRF2 (show GABPA Proteins) expression.
MRTF-A regulated the transcriptional activity of Nrf2 (show GABPA Proteins) by forming a complex with SRF binding to the CarG box which existed on Nrf2 (show GABPA Proteins) promoter region, increasing the resistance of tumor cells to doxorubicin.
Nrf2 (show GABPA Proteins) inhibitors induces growth inhibition and apoptosis of acute myeloid leukemia (show BCL11A Proteins) cells.
Authors showed that upon TMZ treatment there is an induction of the nuclear factor erythroid 2-related factor 2 (NRF2), which is the main antioxidant transcription factor regulator in human cells.
This is the first study to demonstrate that house dust mite antigen-induced sinonasal epithelial cell barrier dysfunction may be preventable by Nrf2 (show GABPA Proteins) activation. The Nrf2 (show GABPA Proteins) antioxidant pathway may represent a potential therapeutic target for allergen-induced sinonasal inflammation.
Vaginal cell-derived Hb-alpha and Hb-beta may have antioxidative properties and protect cells from oxidative stress-induced (show SQSTM1 Proteins) inflammation possibly through Nrf2 (show GABPA Proteins) downstream signaling.
this study demonstrated that Nrf2 (show GABPA Proteins) was significantly elevated in hepatocellular carcinoma cells and tissues and was correlated with poor prognosis
Nrf2 (show GABPA Proteins) suppresses prostate cancer cells viability, migration, and mitosis by upregulating ferroportin (show SLC40A1 Proteins) expression.
The results demonstrated that restoration of Brg1 (show SMARCA4 Proteins) during reperfusion could enhance Nrf2-mediated inducible expression of HO-1 (show HMOX1 Proteins) during hepatic ischemia-reperfusion injury to effectively increase antioxidant ability to combat against hepatocytes damage.
The in vitro study illustrated that the anti-inflammatory effects of RA-XII were partially reversed following Nrf2 and HO-1 (show HMOX1 Proteins) inhibition. Together, these findings strongly suggested that RA-XII is a potential agent against acute kidney injury.
It is a key transcription factor regulating HO-1 (show HMOX1 Proteins) induction.
Nrf2-mediated stimulation of intrarenal Renin (show REN Proteins)-Angiotensin system gene expression, by which chronic hyperglycemia induces hypertension and renal injury in diabetes.
Studied role of nuclear factor (NF)-E2-related factor-2 (Nrf2) and NF-kappaB (show NFKB1 Proteins) in inflammation and apoptosis induced by intestinal ischemia-reperfusion (IIR) in mice; findings indicate a critical role in IIR for Nrf2, possibly thru inhibition of NF-kappaB (show NFKB1 Proteins) pathway.
The p62 (show GTF2H1 Proteins)-keap1 (show KEAP1 Proteins)-Nrf2 antioxidant pathway was primarily activated in the early stage of APAP hepatotoxicity.
Genetic activation of the antioxidant transcription factor Nrf2 improves liver damage and repair in hepatocyte-specific c-met-deficient mice mainly through restoring a balance in the cellular redox homeostasis.
is the first study to report that genetic ablation of Nrf2 exacerbates visual deficits, inflammation of the optic nerve, and RGC degeneration in a murine model of multiple sclerosis.
YZH-106 induced p38 MAPK (show MAPK14 Proteins) and ERK1/2 phosphorylation, which led to the activation of erythroid 2-related factor 2 (Nrf2) that up-regulated heme oxygenase-1 (HO-1 (show HMOX1 Proteins)) expression in addition to other genes.
Ltbp4 regulates Pdgfrb (show PDGFRB Proteins) expression via TGFbeta (show TGFB1 Proteins)-dependent modulation of Nrf2 transcription factor function.
This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters\; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been found for this gene.
, nuclear factor (erythroid-derived 2)-like 2
, nuclear factor erythroid 2-related factor 2
, NF-E2-related factor 2
, NFE2-related factor 2
, nuclear factor, erythroid derived 2, like 2
, nuclear factor erythroid-derived 2-like 2
, nuclear factor erythroid 2-like 2