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anti-Human SEC63 Antibodies:
anti-Mouse (Murine) SEC63 Antibodies:
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Cow (Bovine) Polyclonal SEC63 Primary Antibody for WB - ABIN2782761
You, Li, Kim, Kang, Koh, Chwae, Kim, Kim, Park, Jang, Kim: Selective translational repression of truncated proteins from frameshift mutation-derived mRNAs in tumors. in PLoS biology 2007
GalNAcT6 (show GALNT6 Antibodies) role in cancer [review]
Findings show that the expression of GalNAc-T6 (show GALNT6 Antibodies) in endometrial carcinoma is significantly related to E-cadherin (show CDH1 Antibodies) expression, and better prognosis and overall survival.
Study showed that GalNAc-T6 (show GALNT6 Antibodies) expression in epithelial ovarian carcinoma was different according to pathological type. In low-grade serous carcinoma, GalNAc-T6 (show GALNT6 Antibodies) expression may contribute to improved long-term survival.
GALNT6 (show GALNT6 Antibodies)-induced O-glycosylation is critical for the stability, subcellular localization, and anti-apoptotic function of GRP78 (show HSPA5 Antibodies) protein in cancer cells. We also suggest that GRP78 (show HSPA5 Antibodies) might enhance the activity of GALNT6 (show GALNT6 Antibodies) in carcinogenesis through driving Golgi-to-ER relocation of GALNT6 (show GALNT6 Antibodies).
knockdown of GALNT6 (show GALNT6 Antibodies) caused drastic morphological changes of pancreatic cells, accompanied with the cadherin switching from P-cadherin to E-cadherin (show CDH1 Antibodies).
Role of N-acetylgalactosaminyltransferase (show B4GALNT2 Antibodies) 6 in early tumorigenesis and formation of metastasis.
These data suggest that excess O-glycosylation on APP (show APP Antibodies) by GalNAc-T6 (show GALNT6 Antibodies) inhibits Abeta (show APP Antibodies) production.
a SEC63 germline mutation may play a role in cyst formation in polycystic liver disease
Phosphorylation of Sec63 by CK2 (show CSNK2A1 Antibodies) enhanced its binding to Sec62 (show TLOC1 Antibodies)
Sec63 may perform a substrate-selective quantity control function during cotranslational endoplasmic reticulum import.
SEC63 function regulates IRE1alpha (show ERN1 Antibodies)/XBP1 (show XBP1 Antibodies) activation. SEC63 and XBP1 (show XBP1 Antibodies) are required for GPS (show NBEAL2 Antibodies) cleavage and maturation of PC1 (show PCSK1 Antibodies), protecting against polycystic disease.
The pro-carcinogenic growth behavior of hepatocytes with low SEC63 expression in the murine model indicates a potential role for SEC63 in hepatocarcinogenesis in general.
Knockout of the murine Sec63 gene inhibits transport of precursor proteins into the endoplasmic reticulum.
SEC63 gene expression is up-regulated and predominantly localized in mouse decidual cells during days 5-8 of pregnancy.
disruption of sec63 leads to abnormalities in myelinating glia in both the central and peripheral nervous systems
This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. The encoded protein is capable of glycosylating fibronectin peptide in vitro and is expressed in a fibroblast cell line, indicating that it may be involved in the synthesis of oncofetal fibronectin.
translocation protein SEC63 homolog
, GalNAc transferase 6
, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 6
, UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 6
, polypeptide GalNAc transferase 6
, polypeptide N-acetylgalactosaminyltransferase 6
, pp-GaNTase 6
, protein-UDP acetylgalactosaminyltransferase 6
, SEC63-like protein