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Cow (Bovine) Polyclonal SEC63 Primary Antibody for WB - ABIN2782761
You, Li, Kim, Kang, Koh, Chwae, Kim, Kim, Park, Jang, Kim: Selective translational repression of truncated proteins from frameshift mutation-derived mRNAs in tumors. in PLoS biology 2007
Results suggest that loss of PRKCSH (show PRKCSH Antibodies) and SEC63 leads to general defects in ciliogenesis, while quenching of the Wnt (show WNT2 Antibodies) signaling cascade is cholangiocyte-restricted.
a SEC63 germline mutation may play a role in cyst formation in polycystic liver disease
Phosphorylation of Sec63 by CK2 (show CSNK2A1 Antibodies) enhanced its binding to Sec62 (show TLOC1 Antibodies)
Sec63 may perform a substrate-selective quantity control function during cotranslational endoplasmic reticulum import.
Silencing the human SEC63 genes inhibits transport of only a subset of signal-peptide-containing precursor proteins to endoplasmic reticulum.
identified nucleoredoxin (show NXN Antibodies) as an interaction partner of Sec63; characterized this interaction; Sec63 is linked to the Wnt (show WNT2 Antibodies) signaling pathways and this interaction may be the reason why mutations in SEC63 can lead to polycystic liver disease
identified a total of 26 novel mutations in PRKCSH (show PRKCSH Antibodies) (n = 14) and SEC63 (n = 12), including four splice site mutations, eight insertions/ deletions, six non-sense mutations, and eight missense mutations
Mutations in SEC63 cause autosomal dominant polycystic liver disease, suggesting a role for cotranslational protein-processing pathways in maintaining epithelial luminal structure and implicating noncilial ER proteins in human polycystic disease.
Sec63p expression was observed in all cyst epithelia regardless of mutational state. And, Cystogenesis in SEC63-associated PCLD (show PRKCSH Antibodies) occurs via a different mechanism.
SEC63 function regulates IRE1alpha (show ERN1 Antibodies)/XBP1 (show XBP1 Antibodies) activation. SEC63 and XBP1 (show XBP1 Antibodies) are required for GPS (show NBEAL2 Antibodies) cleavage and maturation of PC1 (show PCSK1 Antibodies), protecting against polycystic disease.
The pro-carcinogenic growth behavior of hepatocytes with low SEC63 expression in the murine model indicates a potential role for SEC63 in hepatocarcinogenesis in general.
Knockout of the murine Sec63 gene inhibits transport of precursor proteins into the endoplasmic reticulum.
SEC63 gene expression is up-regulated and predominantly localized in mouse decidual cells during days 5-8 of pregnancy.
disruption of sec63 leads to abnormalities in myelinating glia in both the central and peripheral nervous systems
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER.
translocation protein SEC63 homolog
, SEC63-like protein