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Human Polyclonal TSPYL2 Primary Antibody for WB - ABIN1881953
Chai, Sarcevic, Mawson, Toh: SET-related cell division autoantigen-1 (CDA1) arrests cell growth. in The Journal of biological chemistry 2001
Show all 5 Pubmed References
Human Polyclonal TSPYL2 Primary Antibody for ELISA, IHC - ABIN4298777
Kandalaft, Zudaire, Portal-Núñez, Cuttitta, Jakowlew: Differentially expressed nucleolar transforming growth factor-beta1 target (DENTT) exhibits an inhibitory role on tumorigenesis. in Carcinogenesis 2008
Genome-wide polysome profiling shows that hCINAP selectively modulates cancer-associated translatome to promote malignancy.
Aortic CDA1 expression was downregulated approximately 70% within biopsies from human abdominal aortic aneurysms.
TSPY and TSPX exert opposing effects on the transactivation functions of AR and AR-Vs important for various physiological and disease processes sensitive to male sex hormone actions, thereby not only affecting the pathogenesis of male-specific prostate cancer but also likely contributing to sex differences in the health and diseases of man.
the extent of the duplicated regions in each case encompassing a minimum of three known disease genes TSPYL2, KDM5C (show KDM5C Antibodies) and IQSEC2 (show IQSEC2 Antibodies), is reported.
homozygous Asp3779Asn and a hemizygous Ile262Met mutations in the LRP2 (show LRP2 Antibodies) and TSPYL2 genes, respectively, in a Pakistani family with two boys affected with mild nonsyndromic intellectual disability
Authors demonstrate that human coilin-interacting nuclear ATPase protein (hCINAP) is a novel negative regulator in NF-kappaB (show NFKB1 Antibodies) signaling by deactivating IkappaB kinase (show CHUK Antibodies) (IKK (show CHUK Antibodies)) complex.
TSPYL2 is an essential component of the REST/NRSF (show REST Antibodies) transcriptional complex for TGFbeta (show TGFB1 Antibodies) signaling activation
The oncogenic events leading to an ectopic activation of TSPY and/or inactivating mutation/epigenetic silencing of TSPX could collectively contribute to the sexual dimorphism(s) in HCC (show FAM126A Antibodies) and related liver cancers in male-biased manners.
More importantly, RPS14 (show RPS14 Antibodies) was specifically modified with NEDD8 (show NEDD8 Antibodies) and hCINAP inhibited RPS14 (show RPS14 Antibodies) NEDDylation by recruiting NEDD8-specific protease 1 (show SENP8 Antibodies)
TSPX is principally expressed in Sertoli cells in the human testis.
Homozygous CINAP-/- mice show embryonic lethality. The heterozygotes are viable and show defects in 18S rRNA processing.
The identification that diabetes is associated with upregulation of vascular CDA1 and that CDA1 deletion in diabetic mice promotes aneurysm formation provides evidence that CDA1 plays a role in diabetes to reduce susceptibility to aneurysm formation.
These findings suggest that disrupting Tspyl2 gene expression leads to behavioral and brain morphological alterations that mirror a number of neurodevelopmental psychiatric traits.
Following infection with T. gondii, myotubes but not myoblasts or fibroblasts further upregulate the negative cell cycle regulator Tspyl2.
We conclude that TSPYL2 contributes to cognitive variability through regulating the expression of Grin2a (show GRIN2A Antibodies) and Grin2b (show GRIN2B Antibodies).
CDA1 deletion reduces but does not block renal TGF-beta (show TGFB1 Antibodies) signaling.
TSPYL2 serves a biological role in maintaining the G1 checkpoint under stress condition.
DENTT may play a role in development of the endocrine tissues, nervous system, lung, oocytes, and thecal cells, and testis [DENTT]
DENTT may play multiple roles in modulating transcriptional responses suggesting new roles for the TTSN superfamily during embryogenesis and differentiation.
Mice treated with hypertonic saline expressed higher CINAP protein levels in the PVN, supporting a role of CINAP in neural response in vivo.
This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth.
CASK-interacting nucleosome assembly protein
, CTCL tumor antigen se20-4
, CTCL-associated antigen se20-4
, TSPY-like protein 2
, cell division autoantigen 1
, cutaneous T-cell lymphoma-associated antigen se20-4
, cutaneous T-cell lymphoma-associated tumor antigen se20-4
, differentially expressed nucleolar TGF-beta1 target
, differentially-expressed nucleolar TGF-beta1 target protein
, nuclear protein of 79 kDa
, testis-specific Y-encoded-like protein 2
, testis-specific protein Y encoded-like 2
, TSPY-like 2
, CASK interacting nucleosome assembly protein
, cell division autoantigen 1 nucleolar protein
, nucleolar TGF-beta1 target protein
, Differentially-expressed nucleolar TGF-beta1 target protein