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Human Polyclonal TSPYL2 Primary Antibody for WB - ABIN1881953
Chai, Sarcevic, Mawson, Toh: SET-related cell division autoantigen-1 (CDA1) arrests cell growth. in The Journal of biological chemistry 2001
Show all 5 Pubmed References
Human Polyclonal TSPYL2 Primary Antibody for ELISA, IHC - ABIN4298777
Kandalaft, Zudaire, Portal-Núñez, Cuttitta, Jakowlew: Differentially expressed nucleolar transforming growth factor-beta1 target (DENTT) exhibits an inhibitory role on tumorigenesis. in Carcinogenesis 2008
Genome-wide polysome profiling shows that hCINAP selectively modulates cancer-associated translatome to promote malignancy.
Aortic CDA1 expression was downregulated approximately 70% within biopsies from human abdominal aortic aneurysms.
TSPY and TSPX exert opposing effects on the transactivation functions of AR and AR-Vs important for various physiological and disease processes sensitive to male sex hormone actions, thereby not only affecting the pathogenesis of male-specific prostate cancer but also likely contributing to sex differences in the health and diseases of man.
the extent of the duplicated regions in each case encompassing a minimum of three known disease genes TSPYL2, KDM5C and IQSEC2, is reported.
homozygous Asp3779Asn and a hemizygous Ile262Met mutations in the LRP2 and TSPYL2 genes, respectively, in a Pakistani family with two boys affected with mild nonsyndromic intellectual disability
Authors demonstrate that human coilin-interacting nuclear ATPase protein (hCINAP) is a novel negative regulator in NF-kappaB signaling by deactivating IkappaB kinase (IKK) complex.
TSPYL2 is an essential component of the REST/NRSF transcriptional complex for TGFbeta signaling activation
Atrial fibrillation can result in alterations in atrial structure and architecture that make the atrial myocardium more susceptible to the maintenance of the arrhythmia.
The oncogenic events leading to an ectopic activation of TSPY and/or inactivating mutation/epigenetic silencing of TSPX could collectively contribute to the sexual dimorphism(s) in HCC and related liver cancers in male-biased manners.
More importantly, RPS14 was specifically modified with NEDD8 and hCINAP inhibited RPS14 NEDDylation by recruiting NEDD8-specific protease 1
hCINAP may not simply regulate nucleotide homeostasis, but may have broader functionality, including control of Cajal body assembly and disassembly
TSPX is principally expressed in Sertoli cells in the human testis.
knockdown of CINAP expression results in marked reduction of histone transcription, lower levels of U small nuclear RNAs (U1, U2, U4, and U5), and a loss of cell viability
hCINAP is a novel coilin-interacting protein encoded by a transcript from the transcription factor TAFIID32 locus
Overexpression of cell division autoantigen-1 (CDA1) slowed parasite growth and induced expression of bradyzoite-specific proteins. Results showed that changes in host cell transcription can influence the molecular environment for bradyzoite development.
CDA1 induces p53- and MEK/ERK1/2 MAPK-dependent expression of p21 by acting through the p53 responsive element in the p21 promoter and this contributes to its antiproliferative activity
a role for DENTT as a suppressor of the tumorigenic phenotype.
This paper characterizes monkey DENTT cDNA and makes a comparison with human and mouse DENTT
Homozygous CINAP-/- mice show embryonic lethality. The heterozygotes are viable and show defects in 18S rRNA processing.
The identification that diabetes is associated with upregulation of vascular CDA1 and that CDA1 deletion in diabetic mice promotes aneurysm formation provides evidence that CDA1 plays a role in diabetes to reduce susceptibility to aneurysm formation.
These findings suggest that disrupting Tspyl2 gene expression leads to behavioral and brain morphological alterations that mirror a number of neurodevelopmental psychiatric traits.
Following infection with T. gondii, myotubes but not myoblasts or fibroblasts further upregulate the negative cell cycle regulator Tspyl2.
We conclude that TSPYL2 contributes to cognitive variability through regulating the expression of Grin2a and Grin2b.
CDA1 deletion reduces but does not block renal TGF-beta signaling.
TSPYL2 serves a biological role in maintaining the G1 checkpoint under stress condition.
DENTT may play a role in development of the endocrine tissues, nervous system, lung, oocytes, and thecal cells, and testis [DENTT]
DENTT may play multiple roles in modulating transcriptional responses suggesting new roles for the TTSN superfamily during embryogenesis and differentiation.
Mice treated with hypertonic saline expressed higher CINAP protein levels in the PVN, supporting a role of CINAP in neural response in vivo.
TSPY gene-specific copy number is useful in determining fetal DNA in the maternal blood of cynomolgus monkeys.
This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth.
CASK-interacting nucleosome assembly protein
, CTCL tumor antigen se20-4
, CTCL-associated antigen se20-4
, TSPY-like protein 2
, cell division autoantigen 1
, cutaneous T-cell lymphoma-associated antigen se20-4
, cutaneous T-cell lymphoma-associated tumor antigen se20-4
, differentially expressed nucleolar TGF-beta1 target
, differentially-expressed nucleolar TGF-beta1 target protein
, nuclear protein of 79 kDa
, testis-specific Y-encoded-like protein 2
, testis-specific protein Y encoded-like 2
, TSPY-like 2
, CASK interacting nucleosome assembly protein
, cell division autoantigen 1 nucleolar protein
, nucleolar TGF-beta1 target protein
, Differentially-expressed nucleolar TGF-beta1 target protein