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This study showed that YOD1 overexpression enhances cell migration by promoting TGF-beta3 signaling which may play an important role in lip and palate formation.
Mechanistically, YOD1 deubiquitinates ITCH, an E3 ligase of LATS, and enhances the stability of ITCH, which leads to reduced levels of LATS and a subsequent increase in the YAP/TAZ level.
Data suggest that YOD1 is a novel regulator of the Hippo pathway, and thereby a potential therapeutic target for liver cancer.
These data define that YOD1 antagonizes TRAF6/p62-dependent IL-1 signaling to NF-kappaB.
Upon damage, p97 translocates to lysosomes and there cooperates with a distinct set of cofactors including UBXD1, PLAA, and the deubiquitinating enzyme YOD1, which we term ELDR components for Endo-Lysosomal Damage Response.
activity of the p97-associated deubiquitinylase YOD1 is also required for substrate disposal
miR-373 increases proliferation by directly targeting YOD1 in cervical cancer.
The assignment of a p97-associated ubiquitin processing function to YOD1 adds to our understanding of p97's role in the dislocation of misfolded proteins from the endoplasmic reticulum.
Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. The protein encoded by this gene belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain. Alternative splicing results in multiple transcript variants.
, HIV-1-induced protease 7
, OTU domain containing 2
, OTU domain-containing protein 2
, YOD1 OTU deubiquinating enzyme 1 homolog ( yeast)
, ubiquitin thioesterase OTU1
, HIV-induced protein-7-like protease
, YOD1 OTU deubiquinating enzyme 1 homolog
, YOD1 OTU deubiquitinating enzyme 1 homologue