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Mechanistically, YOD1 deubiquitinates ITCH, an E3 ligase of LATS, and enhances the stability of ITCH, which leads to reduced levels of LATS and a subsequent increase in the YAP (show YAP1 Proteins)/TAZ (show TAZ Proteins) level.
Data suggest that YOD1 is a novel regulator of the Hippo pathway, and thereby a potential therapeutic target for liver cancer.
These data define that YOD1 antagonizes TRAF6 (show TRAF6 Proteins)/p62 (show GTF2H1 Proteins)-dependent IL-1 (show IL1A Proteins) signaling to NF-kappaB (show NFKB1 Proteins).
Upon damage, p97 (show EIF4G2 Proteins) translocates to lysosomes and there cooperates with a distinct set of cofactors including UBXD1 (show UBXN6 Proteins), PLAA (show PLAA Proteins), and the deubiquitinating enzyme YOD1, which we term ELDR components for Endo-Lysosomal Damage Response.
activity of the p97 (show EIF4G2 Proteins)-associated deubiquitinylase YOD1 is also required for substrate disposal
miR (show MLXIP Proteins)-373 increases proliferation by directly targeting YOD1 in cervical cancer.
The assignment of a p97 (show EIF4G2 Proteins)-associated ubiquitin processing function to YOD1 adds to our understanding of p97 (show EIF4G2 Proteins)'s role in the dislocation of misfolded proteins from the endoplasmic reticulum.
Antigen presenting cells (APCs (show APCS Proteins)) that express a catalytically inactive version of the deubiquitylase YOD1 (YOD1-C160S) present exogenous antigens more efficiently to CD8 (show CD8A Proteins)(+) T cells, both in vitro and in vivo.
Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. The protein encoded by this gene belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain. Alternative splicing results in multiple transcript variants.
, HIV-1-induced protease 7
, OTU domain containing 2
, OTU domain-containing protein 2
, YOD1 OTU deubiquinating enzyme 1 homolog ( yeast)
, ubiquitin thioesterase OTU1
, HIV-induced protein-7-like protease
, YOD1 OTU deubiquinating enzyme 1 homolog
, YOD1 OTU deubiquitinating enzyme 1 homologue