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Human Polyclonal KL Primary Antibody for IF (p), IHC (p) - ABIN681778
Prudhomme, Glinka, Kurt, Liu, Wang: The anti-aging protein Klotho is induced by GABA therapy and exerts protective and stimulatory effects on pancreatic beta cells. in Biochemical and biophysical research communications 2017
Human Polyclonal KL Primary Antibody for ELISA - ABIN450061
Chen, Podvin, Gillespie, Leeman, Abraham: Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17. in Proceedings of the National Academy of Sciences of the United States of America 2007
Human Polyclonal KL Primary Antibody for ELISA, ICC - ABIN4329242
Manrique, Habibi, Aroor, Sowers, Jia, Hayden, Garro, Martinez-Lemus, Ramirez-Perez, Klein, Meininger, DeMarco: Dipeptidyl peptidase-4 inhibition with linagliptin prevents western diet-induced vascular abnormalities in female mice. in Cardiovascular diabetology 2016
Human Polyclonal KL Primary Antibody for IHC (p), IHC - ABIN250843
Kurosu, Yamamoto, Clark, Pastor, Nandi, Gurnani, McGuinness, Chikuda, Yamaguchi, Kawaguchi, Shimomura, Takayama, Herz, Kahn, Rosenblatt, Kuro-o: Suppression of aging in mice by the hormone Klotho. in Science (New York, N.Y.) 2005
Human Polyclonal KL Primary Antibody for WB - ABIN4890528
Chen, Gould, Garza, Gao, Hampton, Newton: Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase. in The Journal of biological chemistry 2007
The change in concentration of soluble alpha-klotho during the 1.5-years follow-up was an indicator of CKD progression. Renal damage associated with a reduction of alpha-klotho may involve the upregulation of plasma aldosterone.
Cord blood klotho levels were inversely correlated with leptin (show LEP Antibodies) and insulin (show INS Antibodies) levels at birth
serum level of FGF-23 (show FGF23 Antibodies) was not correlated with a change in bone mineral density of maintenance hemodialysis patients, whereas the serum Klotho protein level was associated with the degree of bone mineral density
solubility-Klotho level was closely correlated with kidney function
To evaluate the role of klotho in the pathogenesis of systemic sclerosis, its serum concentration was measured in patients compared to healthy controls, and its association with cutaneous and visceral involvement was assessed. Spearman's test showed no significant association between klotho serum levels and systemic sclerosis activity, concerning either clinical, laboratory or instrumental findings.
Klotho may play an inhibiting role in lipopolysaccharide-induced inflammation injury by inhibiting NF-kappaB (show NFKB1 Antibodies) and Wnt (show WNT2 Antibodies) signaling pathways in HK-2 (show HK2 Antibodies) cells.
High klotho expression is associated with renal fibrosis and podocyte injuries.
Although our study revealed higher serum ET-1 (show EDN1 Antibodies) and lower serum alpha-Klotho levels in systemic sclerosis patients compared to healthy controls, there were not any significant correlations between their serum levels with severity of organ involvement.
The A allele of the G395A polymorphism of Klotho, which emerges the higher levels of phosphate, may be associated with the risk of mortality in Iranian patients receiving hemodialysis.
shed alpha-klotho functions as an on-demand non-enzymatic scaffold protein (show HOMER1 Antibodies) that promotes FGF23 (show FGF23 Antibodies) signalling
Klotho has posed antioxidant and anti-apoptotic effects on oxidative injuries in TCMK-1 cells, which might be partially related to its inhibition of JNK (show MAPK8 Antibodies)/MAPK (show MAPK1 Antibodies) and p38/MAPK (show MAPK14 Antibodies) phosphorylation and subsequent elevation of antioxidant enzymes. Increasing Klotho expression has played a protective role against oxidative stress in tubular epithelial cells.
Klotho expression in the central nervous system is associated with total antioxidant capacity in mice with experimental autoimmune encephalomyelitis.
Using mouse strains with parathyroid-specific deletions of Klotho and CaSR (show CASR Antibodies) and dual deletion of both genes, Klotho has a pivotal role in suppressing PTH (show PTH Antibodies) in the absence of CaSR (show CASR Antibodies). Chronic hypocalcemia and ex vivo PTG (show LPCAT3 Antibodies) culture demonstrated an independent role for Klotho in mediating PTH (show PTH Antibodies) secretion.
DPP-4 (show DPP4 Antibodies) inhibition with linagliptin slowed the progression of premature aging in klotho-/- mice. Provide a novel insight into the potential role of DPP-4 (show DPP4 Antibodies) in the mechanism of premature aging.
Klotho protects tubular epithelial cells from renal ischemic-reperfusion injury and its anti-necroptotic role may be associated with oxidative stress inhibition.
studies uncover a novel hypomethylating character of Rhein in preventing Klotho loss and renal fibrosis, and demonstrate the efficacy of Klotho-targeted epigenetic intervention in potential treatment of renal fibrosis-associated kidney diseases.
the main physiological function of Klotho for mineral homeostasis in vivo is its role as co-receptor mediating Fgf23 (show FGF23 Antibodies) action.
Findings establish a key role of osteocyte-expressed Klotho in regulating bone metabolism and indicate a new mechanism by which osteocytes control bone formation.
Selective HDAC3 (show HDAC3 Antibodies) inhibition effectively alleviated Klotho loss and kidney injury, whereas the protective effects were largely abolished when Klotho was knocked down by siRNA, suggesting that aberrant HDAC3 (show HDAC3 Antibodies) and Klotho loss are crucial components involved in the renal damage of mice with chronic kidney disease.
data showed that Klotho protects Tac (show IL2RA Antibodies)-induced oxidative stress by negatively regulating the PI3K/AKT (show AKT1 Antibodies) pathway and subsequently enhancing FoxO3a (show FOXO3 Antibodies)-mediated MnSOD (show SOD2 Antibodies) expression.
Activated HAT (show HAT Antibodies) activity of p300 (show EP300 Antibodies) modulates AV calcification through osteogenic transdifferentiation of VICs with Klotho modulation.
Klotho gene deficiency promotes high-fat diet-induced fibrosis in aortic valves, likely through the AMPKalpha (show GRK4 Antibodies)-RUNX2 (show RUNX2 Antibodies) pathway.
significant expression of FGF23 (show FGF23 Antibodies) and KL within the growth plate and adjacent tissues imply a potential local role of FGF23 (show FGF23 Antibodies) in chondrocyte differentiation and tissue mineralization.
This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss.
secreted form of Klotho protein