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Human Polyclonal KL Primary Antibody for ELISA, ICC - ABIN4329242
Manrique, Habibi, Aroor, Sowers, Jia, Hayden, Garro, Martinez-Lemus, Ramirez-Perez, Klein, Meininger, DeMarco: Dipeptidyl peptidase-4 inhibition with linagliptin prevents western diet-induced vascular abnormalities in female mice. in Cardiovascular diabetology 2016
Human Polyclonal KL Primary Antibody for WB - ABIN4890528
Chen, Gould, Garza, Gao, Hampton, Newton: Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase. in The Journal of biological chemistry 2007
Human Polyclonal KL Primary Antibody for IHC (p), IHC - ABIN250843
Kurosu, Yamamoto, Clark, Pastor, Nandi, Gurnani, McGuinness, Chikuda, Yamaguchi, Kawaguchi, Shimomura, Takayama, Herz, Kahn, Rosenblatt, Kuro-o: Suppression of aging in mice by the hormone Klotho. in Science (New York, N.Y.) 2005
Human Polyclonal KL Primary Antibody for ELISA - ABIN450061
Chen, Podvin, Gillespie, Leeman, Abraham: Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17. in Proceedings of the National Academy of Sciences of the United States of America 2007
Human Polyclonal KL Primary Antibody for FACS, WB - ABIN389493
Sugiyama, Masuda, Shinoda, Nakamura, Tomita, Ishihama: Phosphopeptide enrichment by aliphatic hydroxy acid-modified metal oxide chromatography for nano-LC-MS/MS in proteomics applications. in Molecular & cellular proteomics : MCP 2007
Show all 2 Pubmed References
patients with autosomal dominant polycystic kidney disease may potentially have different soluble alpha-Klotho production/clearance characteristics than the patients with other parenchymal renal diseases.
KL and SFRP1 (show SFRP1 Antibodies) methylation were more predominant in nasopharyngeal tumors.
A statistically significant positive correlation was found between s-Klotho and FGF23 (show FGF23 Antibodies) (r=0.768; p=0.001), and between FGF23 (show FGF23 Antibodies) levels and urinary albumin (show ALB Antibodies) creatinine ratio (r=0.768; p=0.001).
The beta-Klotho (show KLB Antibodies) gene expresses only in retina and optic nerve. The gamma-Klotho gene may regulate human lens epithelial cells' function mainly by the MAPK (show MAPK1 Antibodies)/ERK1/2 (show MAPK1/3 Antibodies) signaling pathway.
Down-Regulation of Soluble alpha-Klotho is Associated with Reduction in Serum Irisin (show FNDC5 Antibodies) Levels in Chronic Obstructive Pulmonary Disease. soluble a-klotho is one possible factor involved in reduced irisin (show FNDC5 Antibodies) release from skeletal muscle
Klotho is a co-receptor for FGF23 (show FGF23 Antibodies). Together they play an important role in bone mineral and vitamin D metabolism. In chronic kidney disease, disturbances in bone metabolism increase cardiovascular risk. In the kidney, klotho induces phosphaturia. Klotho levels drop in chronic kidney disease. It inhibits vascular calcification. Review.
A single copy of klotho allele KL-VS is associated with longevity, better health, increased cognition, and bigger regional brain volume.
Review of Klotho function and dysfunction in mice and humans. [Review Article]
The Klotho KL-VS variant is associated with an increase in the incidence of dementia in older men, in a dose-dependent fashion (intermediate for heterozygosis and highest for homozygosis).
Our findings provide the first evidence that alpha-Klotho is significantly decreased in the microvasculature in systemic sclerosis skin
In conclusion, the excessive 1,25(OH)2D3 formation in klotho-hypomorphic mice has a profound effect on murine behavior.
Klotho is a novel regulator of postnatal neurogenesis affecting neural stem cell proliferation and maturation sufficient to impact hippocampal-dependent spatial memory function.
Reduced Klotho expression aggravates tacrolimus-induced renal injury via the PI3K-Akt (show AKT1 Antibodies)-FoxO (show FOXO3 Antibodies) pathway.
Two distinct isoforms of soluble Klotho appear to play counter-regulatory roles in cardiac fibrogenic responses.
Klotho regulates adipogenic differentiation in adipose-derived stem cells, likely via inhibition of TGFbeta1 (show TGFB1 Antibodies) and activation of PPAR-gamma (show PPARG Antibodies).
Overexpression of Klotho inhibits the differentiation of RAW264.7 cells into osteoclasts.
Data suggest that klotho affects cognition, at least in part, by regulating hippocampal synaptic plasticity.
Adiponectin alters calcium and phosphate balance and renal mineral excretion, in part, through klotho.
These results support the notion that sialogangliosides and lipid rafts are membrane receptors for sKlotho and that the KL1 (show KITLG Antibodies) domain is sufficient for the tested biologic activities.
Activated HAT (show HAT Antibodies) activity of p300 (show EP300 Antibodies) modulates AV calcification through osteogenic transdifferentiation of VICs with Klotho modulation.
Klotho gene deficiency promotes high-fat diet-induced fibrosis in aortic valves, likely through the AMPKalpha (show GRK4 Antibodies)-RUNX2 (show RUNX2 Antibodies) pathway.
significant expression of FGF23 (show FGF23 Antibodies) and KL within the growth plate and adjacent tissues imply a potential local role of FGF23 (show FGF23 Antibodies) in chondrocyte differentiation and tissue mineralization.
This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss.
, kit ligand
, secreted form of Klotho protein