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Human Polyclonal KL Primary Antibody for WB - ABIN4890528
Chen, Gould, Garza, Gao, Hampton, Newton: Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase. in The Journal of biological chemistry 2007
Human Polyclonal KL Primary Antibody for IHC (p), IHC - ABIN250843
Kurosu, Yamamoto, Clark, Pastor, Nandi, Gurnani, McGuinness, Chikuda, Yamaguchi, Kawaguchi, Shimomura, Takayama, Herz, Kahn, Rosenblatt, Kuro-o: Suppression of aging in mice by the hormone Klotho. in Science (New York, N.Y.) 2005
Human Polyclonal KL Primary Antibody for ELISA - ABIN450061
Chen, Podvin, Gillespie, Leeman, Abraham: Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17. in Proceedings of the National Academy of Sciences of the United States of America 2007
Human Polyclonal KL Primary Antibody for IF (p), IHC (p) - ABIN681778
Prudhomme, Glinka, Kurt, Liu, Wang: The anti-aging protein Klotho is induced by GABA therapy and exerts protective and stimulatory effects on pancreatic beta cells. in Biochemical and biophysical research communications 2017
Human Polyclonal KL Primary Antibody for ELISA, ICC - ABIN4329242
Manrique, Habibi, Aroor, Sowers, Jia, Hayden, Garro, Martinez-Lemus, Ramirez-Perez, Klein, Meininger, DeMarco: Dipeptidyl peptidase-4 inhibition with linagliptin prevents western diet-induced vascular abnormalities in female mice. in Cardiovascular diabetology 2016
Human Polyclonal KL Primary Antibody for FACS, WB - ABIN389493
Sugiyama, Masuda, Shinoda, Nakamura, Tomita, Ishihama: Phosphopeptide enrichment by aliphatic hydroxy acid-modified metal oxide chromatography for nano-LC-MS/MS in proteomics applications. in Molecular & cellular proteomics : MCP 2007
Show all 2 Pubmed References
High klotho expression is associated with renal fibrosis and podocyte injuries.
Although our study revealed higher serum ET-1 (show EDN1 Antibodies) and lower serum alpha-Klotho levels in systemic sclerosis patients compared to healthy controls, there were not any significant correlations between their serum levels with severity of organ involvement.
The A allele of the G395A polymorphism of Klotho, which emerges the higher levels of phosphate, may be associated with the risk of mortality in Iranian patients receiving hemodialysis.
shed alpha-klotho functions as an on-demand non-enzymatic scaffold protein (show HOMER1 Antibodies) that promotes FGF23 (show FGF23 Antibodies) signalling
This study showed that A reduced blood alpha-Klotho level was correlated with grading of cerebral Deep White Matter Lesions and was accompanied by cognitive decline as an independent risk factor.
Klotho deficiency is not just a biomarker but a contributing factor to the development of acute kidney injury.
serum FGF23 (show FGF23 Antibodies) levels were significantly higher and soluble Klotho levels significantly lower in the autosomal-dominant polycystic kidney disease group than in the non-diabetic chronic kidney disease group matched for estimated glomerular filtration rate
Forced expression of Klotho resulted in decline of activation of IGF-1R (show IGF1R Antibodies) signaling, accompanied by decreased phosphorylation of its downstream targets, including AKT (show AKT1 Antibodies) and ERK1/2. These data indicated that Klotho acts as a tumor suppressor via inhibiting IGF-1R (show IGF1R Antibodies) signaling, thus suppressing the viability and promoting apoptosis in Tcell lymphoma.
Fibroblast Growth Factor-23 (show FGF23 Antibodies) was higher in alcoholics than in controls, especially among cirrhotics, and soluble alpha Klotho levels were also higher among cirrhotics.
The functional KL-VS variant of the KLOTHO gene protects against the development of retinopathy in patients with T1 diabetes.
DPP-4 (show DPP4 Antibodies) inhibition with linagliptin slowed the progression of premature aging in klotho-/- mice. Provide a novel insight into the potential role of DPP-4 (show DPP4 Antibodies) in the mechanism of premature aging.
Klotho protects tubular epithelial cells from renal ischemic-reperfusion injury and its anti-necroptotic role may be associated with oxidative stress inhibition.
studies uncover a novel hypomethylating character of Rhein in preventing Klotho loss and renal fibrosis, and demonstrate the efficacy of Klotho-targeted epigenetic intervention in potential treatment of renal fibrosis-associated kidney diseases.
the main physiological function of Klotho for mineral homeostasis in vivo is its role as co-receptor mediating Fgf23 (show FGF23 Antibodies) action.
Findings establish a key role of osteocyte-expressed Klotho in regulating bone metabolism and indicate a new mechanism by which osteocytes control bone formation.
Selective HDAC3 (show HDAC3 Antibodies) inhibition effectively alleviated Klotho loss and kidney injury, whereas the protective effects were largely abolished when Klotho was knocked down by siRNA, suggesting that aberrant HDAC3 (show HDAC3 Antibodies) and Klotho loss are crucial components involved in the renal damage of mice with chronic kidney disease.
data showed that Klotho protects Tac (show IL2RA Antibodies)-induced oxidative stress by negatively regulating the PI3K/AKT (show AKT1 Antibodies) pathway and subsequently enhancing FoxO3a (show FOXO3 Antibodies)-mediated MnSOD (show SOD2 Antibodies) expression.
The present study provides a novel approach for klotho gene therapy and demonstrates that direct up-regulation of klotho in the brain might improve aging-related memory impairments and decrease oxidative stress.
Klotho inhibits cigarette smoke-induced autophagy via down-regulation of IGF-1R (show IGF1R Antibodies), Akt (show AKT1 Antibodies), and ERK (show EPHB2 Antibodies) phosphorylation in alveolar macrophages.
In conclusion, the excessive 1,25(OH)2D3 formation in klotho-hypomorphic mice has a profound effect on murine behavior.
Activated HAT (show HAT Antibodies) activity of p300 (show EP300 Antibodies) modulates AV calcification through osteogenic transdifferentiation of VICs with Klotho modulation.
Klotho gene deficiency promotes high-fat diet-induced fibrosis in aortic valves, likely through the AMPKalpha (show GRK4 Antibodies)-RUNX2 (show RUNX2 Antibodies) pathway.
significant expression of FGF23 (show FGF23 Antibodies) and KL within the growth plate and adjacent tissues imply a potential local role of FGF23 (show FGF23 Antibodies) in chondrocyte differentiation and tissue mineralization.
This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss.
secreted form of Klotho protein