Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all species
Show all synonyms
Select your species and application
anti-Mouse (Murine) Antibodies:
anti-Rat (Rattus) Antibodies:
Go to our pre-filtered search.
Human Polyclonal KL Primary Antibody for WB - ABIN4890528
Chen, Gould, Garza, Gao, Hampton, Newton: Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase. in The Journal of biological chemistry 2007
Human Polyclonal KL Primary Antibody for IHC (p), IHC - ABIN250843
Kurosu, Yamamoto, Clark, Pastor, Nandi, Gurnani, McGuinness, Chikuda, Yamaguchi, Kawaguchi, Shimomura, Takayama, Herz, Kahn, Rosenblatt, Kuro-o: Suppression of aging in mice by the hormone Klotho. in Science (New York, N.Y.) 2005
Human Polyclonal KL Primary Antibody for FACS, WB - ABIN389493
Sugiyama, Masuda, Shinoda, Nakamura, Tomita, Ishihama: Phosphopeptide enrichment by aliphatic hydroxy acid-modified metal oxide chromatography for nano-LC-MS/MS in proteomics applications. in Molecular & cellular proteomics : MCP 2007
Show all 2 Pubmed References
Human Polyclonal KL Primary Antibody for ELISA - ABIN450061
Chen, Podvin, Gillespie, Leeman, Abraham: Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17. in Proceedings of the National Academy of Sciences of the United States of America 2007
Human Polyclonal KL Primary Antibody for IF (p), IHC (p) - ABIN681778
Prudhomme, Glinka, Kurt, Liu, Wang: The anti-aging protein Klotho is induced by GABA therapy and exerts protective and stimulatory effects on pancreatic beta cells. in Biochemical and biophysical research communications 2017
Human Polyclonal KL Primary Antibody for ELISA, ICC - ABIN4329242
Manrique, Habibi, Aroor, Sowers, Jia, Hayden, Garro, Martinez-Lemus, Ramirez-Perez, Klein, Meininger, DeMarco: Dipeptidyl peptidase-4 inhibition with linagliptin prevents western diet-induced vascular abnormalities in female mice. in Cardiovascular diabetology 2016
Fibroblast Growth Factor-23 (show FGF23 Antibodies) was higher in alcoholics than in controls, especially among cirrhotics, and soluble alpha Klotho levels were also higher among cirrhotics.
The functional KL-VS variant of the KLOTHO gene protects against the development of retinopathy in patients with T1 diabetes.
the immunohistochemical expressions of Klotho and DNMT3a (show DNMT3A Antibodies) in tissues obtained from oral dysplasia and oral squamous cell carcinoma, is reported.
We show that rosiglitazone increases klotho and decreases Wnt5A (show WNT5A Antibodies) in tumor cells, reducing the burden of both BRAF (show BRAF Antibodies) inhibitor-sensitive and BRAF (show BRAF Antibodies) inhibitor-resistant tumors in aged, but not young mice. However, when used in combination with PLX4720, tumor burden was reduced in both young and aged mice, even in resistant tumors
Klotho suppresses Sox9 (show SOX9 Antibodies) upregulation and intranuclear translocation. Klotho inhibits high phosphate-induced osteogenic activity in human aortic valve interstitial cells.
Data suggest that serum levels of alpha-klotho and beta-klotho (show KLB Antibodies) are down-regulated in patients with type 2 diabetes, regardless of diabetic complications.
Low expression levels of Klotho were observed in DLBCL patients and cell lines. Enforced expression of Klotho could significantly induce cell apoptosis and inhibit tumor growth in DLBCL. Upregulation of Klotho resulted in declined activation of IGF-1R signaling, accompanied with decreased phosphorylation of its downstream targets, including AKT and ERK1/2.
Data suggest that plasma alpha-klotho is down-regulated in subjects with type 2 diabetes as diabetic nephropathy progresses; plasma alpha-klotho level (not urinary alpha-klotho level) may be an early biomarker for predicting renal impairment in type 2 diabetes.
Hmgb1 (show HMGB1 Antibodies) can inhibit Klotho gene expression and malignant phenotype in melanoma cells through activation of NF-kappaB (show NFKB1 Antibodies) signaling.
patients with autosomal dominant polycystic kidney disease may potentially have different soluble alpha-Klotho production/clearance characteristics than the patients with other parenchymal renal diseases.
Findings establish a key role of osteocyte-expressed Klotho in regulating bone metabolism and indicate a new mechanism by which osteocytes control bone formation.
Selective HDAC3 (show HDAC3 Antibodies) inhibition effectively alleviated Klotho loss and kidney injury, whereas the protective effects were largely abolished when Klotho was knocked down by siRNA, suggesting that aberrant HDAC3 (show HDAC3 Antibodies) and Klotho loss are crucial components involved in the renal damage of mice with chronic kidney disease.
data showed that Klotho protects Tac (show IL2RA Antibodies)-induced oxidative stress by negatively regulating the PI3K/AKT (show AKT1 Antibodies) pathway and subsequently enhancing FoxO3a (show FOXO3 Antibodies)-mediated MnSOD (show SOD2 Antibodies) expression.
The present study provides a novel approach for klotho gene therapy and demonstrates that direct up-regulation of klotho in the brain might improve aging-related memory impairments and decrease oxidative stress.
Klotho inhibits cigarette smoke-induced autophagy via down-regulation of IGF-1R (show IGF1R Antibodies), Akt (show AKT1 Antibodies), and ERK (show EPHB2 Antibodies) phosphorylation in alveolar macrophages.
In conclusion, the excessive 1,25(OH)2D3 formation in klotho-hypomorphic mice has a profound effect on murine behavior.
Klotho is a novel regulator of postnatal neurogenesis affecting neural stem cell proliferation and maturation sufficient to impact hippocampal-dependent spatial memory function.
Reduced Klotho expression aggravates tacrolimus-induced renal injury via the PI3K-Akt (show AKT1 Antibodies)-FoxO (show FOXO3 Antibodies) pathway.
Two distinct isoforms of soluble Klotho appear to play counter-regulatory roles in cardiac fibrogenic responses.
Klotho regulates adipogenic differentiation in adipose-derived stem cells, likely via inhibition of TGFbeta1 (show TGFB1 Antibodies) and activation of PPAR-gamma (show PPARG Antibodies).
Activated HAT (show HAT Antibodies) activity of p300 (show EP300 Antibodies) modulates AV calcification through osteogenic transdifferentiation of VICs with Klotho modulation.
Klotho gene deficiency promotes high-fat diet-induced fibrosis in aortic valves, likely through the AMPKalpha (show GRK4 Antibodies)-RUNX2 (show RUNX2 Antibodies) pathway.
significant expression of FGF23 (show FGF23 Antibodies) and KL within the growth plate and adjacent tissues imply a potential local role of FGF23 (show FGF23 Antibodies) in chondrocyte differentiation and tissue mineralization.
This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss.
secreted form of Klotho protein