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The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members. Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript variants have been described but require experimental validation.
Fc fragment of IgE, high affinity I, receptor for; beta polypeptide
, High affinity immunoglobulin epsilon receptor beta-subunit (FcERI) (IgE Fc receptor, beta-subunit) (Fc epsilon receptor I beta-chain)
, high affinity IgE receptor beta subunit
, high affinity immunoglobulin epsilon receptor subunit beta
, igE Fc receptor subunit beta
, immunoglobulin E receptor, high affinity, beta polypeptide
, Fc receptor, IgE, high affinity I, beta polypeptide
, fc epsilon receptor I beta-chain
, membrane-spanning 4-domains, subfamily A, member 1
, IgE Fc receptor subunit beta
, Membrane-spanning 4-domains subfamily A member 1
, Membrane-spanning 4-domains, subfamily A, member 1
, beta polypeptide)
, membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for
, membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)