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PDGFRalpha/PDGFRbeta signaling balance determines progenitor commitment to beige (PDGFRalpha) or white (PDGFRbeta) adipogenesis.
The data of this study revealed an acute accumulation of PDGFRbeta+ BBB-related cells in degenerating brain areas, which can be long lasting, suggesting an active role for PDGFRbeta-signaling in blood vessel and post-injury tissue recovery.
Ltbp4 regulates Pdgfrb expression via TGFbeta (show TGFB1 Proteins)-dependent modulation of Nrf2 (show NFE2L2 Proteins) transcription factor function.
The results provide functional evidence that elevated PDGFRbeta signaling causes tissue wasting or overgrowth reminiscent of human genetic syndromes and that the STAT1 (show STAT1 Proteins) pathway is a crucial modulator of this phenotypic spectrum.
Identify PDGFRbeta as a driver in activating Akt (show AKT1 Proteins)/mTORC1 nexus for high glucose-mediated expression of collagen I (alpha2) in proximal tubular epithelial cells, which contributes to tubulointerstitial fibrosis in diabetic nephropathy.
Data show that three platelet-derived growth factor receptor beta (PDGFRB) mutants (R561C, P660T and N666K) were able to transform NIH3T3 and Ba/F3 cells to different extents.
data therefore collectively suggest that upon TGFbeta (show TGFB1 Proteins) stimulation, SP1 (show SP1 Proteins) recruits SMAD2 (show SMAD2 Proteins) to the promoter of Pdgfrb to up-regulate its expression and thus Pdgfrb is a direct downstream target of the TGFbeta (show TGFB1 Proteins)/SMAD2 (show SMAD2 Proteins) signaling
PdgfrbetaF7/F7 mice between 4-6 and 36-48 weeks of age developed a region-dependent loss in pericyte coverage (22-46, 24-44 and 4-31%) and cell numbers (36-49, 34-64 and 11-36%), reduction in capillary length (20-39, 13-46 and 1-30%), and an increase in extravascular fibrinogen-derived deposits (3.4-5.2, 2.8-4.1 and 0-3.6-fold) demonstrating BBB breakdown in the cortex, hippocampus and thalamus, respectively.
PDGF-B (show PDGFB Proteins)-PDGFRbeta signaling plays a significant role in the development of adipose tissue neovascularization.
there is great possibility that EPCs overexpressing PDGFR-beta enhanc VSMC apoptosis and suppress VSMC migration by competitive consumption of PDGF (show PDGFA Proteins)-BB in the early phase after carotid artery injury in mice.
anlotinib inhibits the activation of VEGFR2 (show KDR Proteins), PDGFRbeta and FGFR1 (show FGFR1 Proteins) as well their common downstream ERK (show EPHB2 Proteins) signaling
PDGFRB is not a major causative gene of primary familial brain calcification in Chinese population.
overview of primary cilia-mediated regulation of receptor tyrosine kinase (show RET Proteins) (RTK- PDGFRa (show PDGFRA Proteins) and PDGFRb) and transforming growth factor beta (TGF-beta) signaling [review]
These findings indicate that the levels of phosphorylated PDGFR-beta are decreased in endothelial progenitor cells with the in vitro expansion process, which impairs their angiogenic potential by inhibiting PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) signaling.
This review showed that PDGFRB was one of the common gene involved included with brain calcification
Data indicate a positive association between LETM1 up-regulation, YAP1 nuclear localization and high PDGFB expression.
This is the first report of a Korean family that carries a PDGFRB mutation potentially responsible for supernumerary premolars. Our results demonstrate the power of next-generation sequencing in rapidly determining the genetic aetiology of numerical tooth abnormalities.
Perivascular PDGFR-alpha (show PDGFRA Proteins) and -beta were identified as independent markers predicting survival in metastatic colorectal cancer (mCRC).
Genetic analyses indicated a platelet derived growth factor receptor beta (PDGFRB) gene missense heterozygous germline mutation in a newborn boy, and his sister suffered from skull base tumor with same genotype and histology.
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor\; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.
CD140 antigen-like family member B
, PDGF beta chain
, beta platelet-derived growth factor receptor
, beta-type platelet-derived growth factor receptor
, platelet-derived growth factor receptor 1
, platelet-derived growth factor receptor beta
, platelet-derived growth factor receptor beta variant 1
, Platelet-derived growth factor receptor, beta
, protein tyrosin kinase