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RPS27a enhances viral LMP1 (show PDLIM7 Proteins)-mediated proliferation and invasion, suggesting that RPS27a interacts with LMP1 (show PDLIM7 Proteins) and stabilizes it by suppressing proteasome-mediated ubiquitination.
Imatinib-resistant K562/G01 cells expressed significantly higher levels of STAT3 (show STAT3 Proteins) and RPS27a compared with those of K562 cells.
RPS27A expression was found to have a weak inverse correlation with overexpression of multifunctional protein YB-1 (show YBX1 Proteins) in HCC (show FAM126A Proteins) tissues.
RPS27a appears to be a novel stress sensor in the cell which amplifies p53 (show TP53 Proteins) response to arrest cell cycle.
Knockdown of RPS27a inhibits the proliferation, induces cell cycle arrest and potentiates the effect of imatinib on apoptosis of K562 cells.
Gene expression profiles showed that RPS27A was down-regulated in epidermolysis bullosa subtypes.
S27a plays a non-redundant role in mediating p53 (show TP53 Proteins) activation in response to ribosomal stress via interplaying with MDM2 (show MDM2 Proteins).
ubiquitin carboxyl extension protein 1 is overexpressed in prostate cancer
Ubiquitin, a highly conserved protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome, is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein S27a at the C terminus. When expressed in yeast, the protein is post-translationally processed, generating free ubiquitin monomer and ribosomal protein S27a. Ribosomal protein S27a is a component of the 40S subunit of the ribosome and belongs to the S27AE family of ribosomal proteins. It contains C4-type zinc finger domains and is located in the cytoplasm. Pseudogenes derived from this gene are present in the genome. As with ribosomal protein S27a, ribosomal protein L40 is also synthesized as a fusion protein with ubiquitin\; similarly, ribosomal protein S30 is synthesized as a fusion protein with the ubiquitin-like protein fubi. Multiple alternatively spliced transcript variants that encode the same proteins have been identified.
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, ribosomal protein S27A
, ubiquitin fusion 80
, 40S ribosomal protein S27a
, ubiquitin C
, ubiquitin and ribosomal protein S27a
, ubiquitin carboxyl extension protein 80
, ubiquitin-40S ribosomal protein S27a
, ubiquitin/ribosomal protein
, ubiquitin extention protein