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anti-Human AOC3 Antibodies:
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Human Monoclonal AOC3 Primary Antibody for Func, IHC (fro) - ABIN2192061
Martelius, Salaspuro, Salmi, Krogerus, Höckerstedt, Jalkanen, Lautenschlager: Blockade of vascular adhesion protein-1 inhibits lymphocyte infiltration in rat liver allograft rejection. in The American journal of pathology 2004
Show all 2 Pubmed References
Human Polyclonal AOC3 Primary Antibody for IHC, IHC (p) - ABIN4364831
Ek, Andréasson, Hober, Kampf, Pontén, Uhlén, Merz, Borrebaeck: From gene expression analysis to tissue microarrays: a rational approach to identify therapeutic and diagnostic targets in lymphoid malignancies. in Molecular & cellular proteomics : MCP 2006
Show all 2 Pubmed References
Human Polyclonal AOC3 Primary Antibody for IHC (p), WB - ABIN522088
Hernandez-Guillamon, Solé, Delgado, García-Bonilla, Giralt, Boada, Penalba, García, Flores, Ribó, Alvarez-Sabin, Ortega-Aznar, Unzeta, Montaner: VAP-1/SSAO plasma activity and brain expression in human hemorrhagic stroke. in Cerebrovascular diseases (Basel, Switzerland) 2012
Human Polyclonal AOC3 Primary Antibody for IHC (p), IHC - ABIN188730
Forster-Horváth, Döme, Paku, Ladányi, Somlai, Jalkanen, Tímár: Loss of vascular adhesion protein-1 expression in intratumoral microvessels of human skin melanoma. in Melanoma research 2004
Human Monoclonal AOC3 Primary Antibody for FACS, ICC - ABIN4364830
Weston, Shepherd, Claridge, Rantakari, Curbishley, Tomlinson, Hubscher, Reynolds, Aalto, Anstee, Jalkanen, Salmi, Smith, Day, Adams: Vascular adhesion protein-1 promotes liver inflammation and drives hepatic fibrosis. in The Journal of clinical investigation 2015
The study showed that serum VAP-1 level increased with an increasing severity of obstruction in patients with stable COPD (show ARCN1 Antibodies). This increase was associated with a reduced quality of life and increased severity of hypoxia.
VAP-1 expression is increased in primary sclerosing cholangitis, facilitates adhesion of gut (show GUSB Antibodies)-tropic lymphocytes to liver endothelium in a substrate-dependent manner, and elevated levels of its circulating form predict clinical outcome in patients.
proangiogenic factor VEGF (show VEGFA Antibodies) induces sVAP-1 (show SNAP47 Antibodies) release from retinal capillary endothelial cells and facilitates hydrogen peroxide generation via enzymatic property of sVAP-1 (show SNAP47 Antibodies), followed by the increase of oxidative stress, one of the crucial factors in the pathogenesis of DR.
immunohistochemistry revealed that VAP-1 localized to endothelial cells of intra-plaque neovessels in carotid endarterectomy samples from patients with recent ischemic symptoms
Adipose tissue SSAO (show AOC2 Antibodies) activity did not vary according to anatomical location and/or metabolic status in severely obese women.
Correlation among soluble receptors for advanced glycation end-products, soluble vascular adhesion protein-1/semicarbazide-sensitive amine oxidase (sVAP-1 (show SNAP47 Antibodies)) and cardiometabolic risk markers in apparently healthy adolescents: a cross-sectional study
This study showed that the oxidase activity of AOC3 contributes to the development of lung fibrosis mainly by regulating the accumulation of pathogenic leukocyte subtypes, which drive the fibrotic response.
The mechanism of the Siglec-9 and AOC3 interaction
psoriatic patients with the dominant AT1R-A1166C polymorphism had significantly higher serum levels of VAP-1 and MDA but lower total bilirubine, uric acid, ARE, SOD and CAT activities compared to the corresponding control group
These findings suggest that vaspin (show SERPINA12 Antibodies) and VAP-1 may play a role in the pathogenesis of psoriasis and can be used as markers of the disease
Homodimeric and monomeric SMOXs are catalytically active, as revealed after gel staining for enzymatic activity. An engineered SMOX (show SMOX Antibodies) mutant deprived of all but two cysteine residues was prepared and characterized experimentally, resulting in a monomeric species. High-sensitivity differential scanning calorimetry of SMOX (show SMOX Antibodies) was compared with that of bovine serum amine oxidase, to analyse their thermal stability.
The lysine-rich protein soluble elastin (show ELN Antibodies) bound to the enzyme tightly, which may have relevance to the reported roles of copper-containing quinoenzyme semicarbazide-sensitive amine oxidase in maintaining the extracellular matrix and in maturation of elastin (show ELN Antibodies)
Data indicate strong-to-moderate expression of vascular adhesion protein-1 (VAP-1) in the synovium of Borrelia burgdorferi-infected mice, while only weak expression of VAP-1 was detected in uninfected mice.
VAP-1 was expressed on endothelial cells lining inflamed atherosclerotic lesions; normal vessel walls in aortas of C57BL/6N control mice were VAP-1-negative.
VAP-1 plays a critical role in the pathophysiology of renal ischemia/reperfusion injury by enhancement of neutrophil infiltration generating a local hydrogen peroxide gradient.
data indicate that SSAO inactivation in vivo stabilizes the established plaques mainly via inducing the switch of SMCs from a contractile to a synthetic phenotype
Suggest inhibiting VAP-1/SSAO enzymatic function, by PXS-4728A, as a novel therapeutic approach in lung diseases that are characterized by neutrophilic pattern of inflammation.
these results link the amine oxidase (show MAOA Antibodies) activity of VAP-1 with hepatic inflammation and fibrosis and suggest that targeting VAP-1 has therapeutic potential for NAFLD (show TSC2 Antibodies) and other chronic fibrotic liver diseases.
these results suggest a largely redundant function for AOC3/VAP-1 in allergic inflammatory responses of the airways.
The results of the study establish VCAM-1 (show VCAM1 Antibodies) and VAP-1 as mediators of myeloid cell recruitment in metastasis and identify VAP-1 as a potential target for therapeutic intervention to combat early metastasis.
The antihyperglycemic effect of benzylamine is abolished by AOC3 gene knockout in mice.
This gene encodes a member of the semicarbazide-sensitive amine oxidase family. Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The encoded protein is localized to the cell surface, has adhesive properties as well as monoamine oxidase activity, and may be involved in leukocyte trafficking. Alterations in levels of the encoded protein may be associated with many diseases, including diabetes mellitus. A pseudogene of this gene has been described and is located approximately 9-kb downstream on the same chromosome. Alternative splicing results in multiple transcript variants.
amine oxidase, copper containing 3 (vascular adhesion protein 1)
, copper amine oxidase
, membrane primary amine oxidase
, placenta copper monamine oxidase
, semicarbazide-sensitive amine oxidase
, amine oxidase, copper containing 2
, amine oxidase, copper containing 2 (retina-specific)
, primary amine oxidase, liver isozyme
, serum amine oxidase
, vascular adhesion protein 1
, copper containing amine oxidase 3
, primary amine oxidase, lung isozyme