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anti-Human AOC3 Antibodies:
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Human Monoclonal AOC3 Primary Antibody for Func, IHC (fro) - ABIN2192061
Martelius, Salaspuro, Salmi, Krogerus, Höckerstedt, Jalkanen, Lautenschlager: Blockade of vascular adhesion protein-1 inhibits lymphocyte infiltration in rat liver allograft rejection. in The American journal of pathology 2004
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Human Polyclonal AOC3 Primary Antibody for IHC, IHC (p) - ABIN4364831
Ek, Andréasson, Hober, Kampf, Pontén, Uhlén, Merz, Borrebaeck: From gene expression analysis to tissue microarrays: a rational approach to identify therapeutic and diagnostic targets in lymphoid malignancies. in Molecular & cellular proteomics : MCP 2006
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Human Polyclonal AOC3 Primary Antibody for ELISA - ABIN547829
Forster-Horváth, Döme, Paku, Ladányi, Somlai, Jalkanen, Tímár: Loss of vascular adhesion protein-1 expression in intratumoral microvessels of human skin melanoma. in Melanoma research 2004
Human Polyclonal AOC3 Primary Antibody for IHC (p), WB - ABIN522088
Hernandez-Guillamon, Solé, Delgado, García-Bonilla, Giralt, Boada, Penalba, García, Flores, Ribó, Alvarez-Sabin, Ortega-Aznar, Unzeta, Montaner: VAP-1/SSAO plasma activity and brain expression in human hemorrhagic stroke. in Cerebrovascular diseases (Basel, Switzerland) 2012
Human Monoclonal AOC3 Primary Antibody for FACS, ICC - ABIN4364830
Weston, Shepherd, Claridge, Rantakari, Curbishley, Tomlinson, Hubscher, Reynolds, Aalto, Anstee, Jalkanen, Salmi, Smith, Day, Adams: Vascular adhesion protein-1 promotes liver inflammation and drives hepatic fibrosis. in The Journal of clinical investigation 2015
The study showed that serum VAP-1 level increased with an increasing severity of obstruction in patients with stable COPD. This increase was associated with a reduced quality of life and increased severity of hypoxia.
VAP-1 expression is increased in primary sclerosing cholangitis, facilitates adhesion of gut-tropic lymphocytes to liver endothelium in a substrate-dependent manner, and elevated levels of its circulating form predict clinical outcome in patients.
proangiogenic factor VEGF induces sVAP-1 release from retinal capillary endothelial cells and facilitates hydrogen peroxide generation via enzymatic property of sVAP-1, followed by the increase of oxidative stress, one of the crucial factors in the pathogenesis of DR.
immunohistochemistry revealed that VAP-1 localized to endothelial cells of intra-plaque neovessels in carotid endarterectomy samples from patients with recent ischemic symptoms
Adipose tissue SSAO activity did not vary according to anatomical location and/or metabolic status in severely obese women.
Correlation among soluble receptors for advanced glycation end-products, soluble vascular adhesion protein-1/semicarbazide-sensitive amine oxidase (sVAP-1) and cardiometabolic risk markers in apparently healthy adolescents: a cross-sectional study
This study showed that the oxidase activity of AOC3 contributes to the development of lung fibrosis mainly by regulating the accumulation of pathogenic leukocyte subtypes, which drive the fibrotic response.
The mechanism of the Siglec-9 and AOC3 interaction
psoriatic patients with the dominant AT1R-A1166C polymorphism had significantly higher serum levels of VAP-1 and MDA but lower total bilirubine, uric acid, ARE, SOD and CAT activities compared to the corresponding control group
These findings suggest that vaspin and VAP-1 may play a role in the pathogenesis of psoriasis and can be used as markers of the disease
Our results show that colorectal myofibroblasts, as defined by the expression of AOC3, NKX2-3, and other markers, are a distinctly different cell type from TGFbeta-activated fibroblasts
In this article, we will review the general characteristics and biological functions of VAP-1, focusing on its important role as a prognostic biomarker in human pathologies. [review]
serum VAP-1 can predict ESRD and is a useful biomarker to improve risk stratification in type 2 diabetic subjects.
It stimulates amyloid beta proteins on the vascular walls, and is contributing to cerebral amyloid angiopathies and Alzheimer disease.
Higher serum VAP-1 and Chronic kidney disease can independently predict future development of cancers in type II diabetic subjects
Complexes of human ORP2 and VAPs at endoplasmic reticulum-lipid droplet interfaces regulate the hydrolysis of triglycerides and lipid droplet turnover.
these results link the amine oxidase activity of VAP-1 with hepatic inflammation and fibrosis and suggest that targeting VAP-1 has therapeutic potential for NAFLD and other chronic fibrotic liver diseases.
the semicarbazide-sensitive amine oxidase activity of VAP-1 modifies hepatic glucose homeostasis and may contribute to patterns of GLUT expression in chronic disease.
This study demonstrated that low serum VAP-1 levels are associated with poor prognosis in gastric cancer patients.
Serum VAP-1 predicts mortality independently and improves risk stratification in colorectal cancer subjects.
Data indicate strong-to-moderate expression of vascular adhesion protein-1 (VAP-1) in the synovium of Borrelia burgdorferi-infected mice, while only weak expression of VAP-1 was detected in uninfected mice.
VAP-1 was expressed on endothelial cells lining inflamed atherosclerotic lesions; normal vessel walls in aortas of C57BL/6N control mice were VAP-1-negative.
VAP-1 plays a critical role in the pathophysiology of renal ischemia/reperfusion injury by enhancement of neutrophil infiltration generating a local hydrogen peroxide gradient.
data indicate that SSAO inactivation in vivo stabilizes the established plaques mainly via inducing the switch of SMCs from a contractile to a synthetic phenotype
Suggest inhibiting VAP-1/SSAO enzymatic function, by PXS-4728A, as a novel therapeutic approach in lung diseases that are characterized by neutrophilic pattern of inflammation.
these results suggest a largely redundant function for AOC3/VAP-1 in allergic inflammatory responses of the airways.
The results of the study establish VCAM-1 and VAP-1 as mediators of myeloid cell recruitment in metastasis and identify VAP-1 as a potential target for therapeutic intervention to combat early metastasis.
The antihyperglycemic effect of benzylamine is abolished by AOC3 gene knockout in mice.
Long-term activation of semicarbazide-sensitive amine oxidase by benzylamine lowers circulating levels of uric acid in diabetic conditions.
AOC3 expression is increased in perigonadal and subcutaneous adipose tissue of diabetic db-/- obese mice.
This review examines the biological functions of VAP-1, especially the role that this molecule might play in the establishment and progression of chronic liver disease.
The demonstrated AOC3 turnover of primary amines that are non-native to human tissue suggests possible roles for the adipocyte enzyme in subcutaneous bacterial infiltration and obesity.
VAP-1-mediated M2 macrophage infiltration underlies IL-1beta- but not VEGF-A-induced lymph- and angiogenesis
VAP-1 inhibition provided antiinflammation effect by reducing adhesion molecule expression and immune cell infiltration after intracerebral hemorrhage.
histamine moderately activated lipolysis in adipocytes in AOC3 knockout mice
Enzyme is in involved in deamination in atherogenesis in KKAy diabetic mice fed with high cholesterol diet.
the increased enzyme activity observed in diabetes is not a result of increased SSAO gene transcription. It is controlled by posttranslational modifications of the protein, and the catalytic activity controls the gene expression
vascular adhesion protein-1 expression may contribute to the functional heterogeneity of endothelial cells within the lung to create distinct sites for the recruitment of inflammatory cells
The lysine-rich protein soluble elastin bound to the enzyme tightly, which may have relevance to the reported roles of copper-containing quinoenzyme semicarbazide-sensitive amine oxidase in maintaining the extracellular matrix and in maturation of elastin
This gene encodes a member of the semicarbazide-sensitive amine oxidase family. Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The encoded protein is localized to the cell surface, has adhesive properties as well as monoamine oxidase activity, and may be involved in leukocyte trafficking. Alterations in levels of the encoded protein may be associated with many diseases, including diabetes mellitus. A pseudogene of this gene has been described and is located approximately 9-kb downstream on the same chromosome. Alternative splicing results in multiple transcript variants.
amine oxidase, copper containing 3 (vascular adhesion protein 1)
, copper amine oxidase
, membrane primary amine oxidase
, placenta copper monamine oxidase
, semicarbazide-sensitive amine oxidase
, amine oxidase, copper containing 2
, amine oxidase, copper containing 2 (retina-specific)
, vascular adhesion protein 1
, copper containing amine oxidase 3
, primary amine oxidase, lung isozyme