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anti-Human NMUR2 Antibodies:
anti-Mouse (Murine) NMUR2 Antibodies:
anti-Rat (Rattus) NMUR2 Antibodies:
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Human Polyclonal NMUR2 Primary Antibody for ELISA, EM - ABIN314877
Kasper, McCue, Milton, Szwed, Sampson, Huang, Carlton, Meltzer, Cunningham, Hommel: Gamma-Aminobutyric Acidergic Projections From the Dorsal Raphe to the Nucleus Accumbens Are Regulated by Neuromedin U. in Biological psychiatry 2016
Show all 4 Pubmed References
NMUR1 mRNA was widely expressed in peripheral tissues, whereas NMUR2 mRNA was mainly expressed in the central nervous system
The data showed that there were developmental changes in NMS and NMUR2 in the reproductive axis of the male Xiaomeishan pigs, postnatally, which suggested that NMS and NMUR2 might have a role in the development of the boar reproductive axis, but its regulatory mechanism remains to be elucidated.
distribution in brain and other organs
NMU2R mRNA expression in the hypothalamus and pituitary changed with the estrus cycle, with the highest level in the proestrus group and the lowest in the estrus group.
Activation by NMU2 is longer lasting if NmS is the ligand.
NMU might contribute to progression of NMUR2-positive breast cancer
polymorphisms in the gene may be useful in identifying women at risk for osteoporosis.
Study identified a novel NMUR2 splice variant lacking the third exon and able to form heteromeric complexes with NMUR1 and NMUR2 without Neuromedin U (NMU). Its expression can block NMU signaling suppressing then ovarian cancer cells proliferation.
A cell-based reporter gene assay has been developed and used for the screening of the human NMU2R agonist.
The present data do not support a significant contribution of NMUR2 to the development of hypersensitivity after nerve injury or tissue inflammation
Data show that deficiency of neuromedin receptors NMUR1 and NMUR2 had no impact on arthritis severity.
The circadian rhythm of neuromedin U expression in the suprachiasmatic nucleus does not drive a circadian rhythm of corticotrophin-releasing factor in the paraventricular nucleus.
molecular basis of the NMU2R regulation of food intake and body weight in mice
Plays a more significant role in central pain processing than other brain functions including stress/anxiety and regulation of feeding.
the pro-nociceptive effects of neuromedin U in mice appear to be mediated through NMUR2, not NMUR1
Long-term central NMU treatment reduces body weight, food intake, and adiposity and that central NMUR2 signaling is required for these effects in female but not male mice.
This gene encodes a protein from the G-protein coupled receptor 1 family. This protein is a receptor for neuromedin U, which is a neuropeptide that is widely distributed in the gut and central nervous system. This receptor plays an important role in the regulation of food intake and body weight.
neuromedin U receptor type 2
, neuromedin U receptor 2
, neuromedin s receptor 2 protein
, G-protein coupled receptor FM-4
, G-protein coupled receptor TGR-1
, growth hormone secretagogue receptor family, member 4
, neuromedin-U receptor 2
, G-protein-coupled receptor FM-4