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NPY5R is an inducible pro-survival factor that is responsible for chemoresistance in neuroblastoma (show ARHGEF16 Proteins) cells.
Variations in genes AGRP (show AGRP Proteins), CPE (show CPE Proteins), GHRL (show GHRL Proteins), GLP1R (show GLP1R Proteins), HTR2A, NPY1R (show NPY1R Proteins), NPY5R, SOCS3 (show SOCS3 Proteins) and STAT3 (show STAT3 Proteins) showed modest associations with BMI in European Americans.
these data highlight a novel mechanism by which NPY (show NPY Proteins) may promote breast cancer progression, and further implicate a pathological role of the NPY (show NPY Proteins) Y5R.
Together, our results suggest that Y5R plays an important role in cancer cell growth and migration and could be a novel therapeutic target for breast cancer.
NPY1R (show NPY1R Proteins) and NPY5R have roles in nutrient-specific food intake in Europeans
The authenticity of this transcript was confirmed by isolating part of its 5'UTR and analysing its tissue distribution,, we have shown that the two AUG triplets contained in the 5' untranslated region of Y5(L) mRNA did not affect receptor expression
Neuropeptide-Y (show NPY Proteins) induced endothelial cell migration was mimicked by agonists and fully blocked by antagonists for any specific NPY (show NPY Proteins) receptor (NPY5R).
single nucleotide polymorphisms in the NPY5R gene may have a role in dyslipidemia (elevated triglyceride concentrations and reduced high-density lipoprotein levels) in Mexican Americans
Sequence variations in neuropeptide Y (show NPY Proteins) receptor genes (NPY5R and NPY2R (show NPY2R Proteins)) are associated with alcohol dependence, cocaine dependence, and comorbid alcohol and cocaine dependence.
Results suggest that rabbit and human Y1, Y2 and Y5 receptor subtypes are well conserved, whereas Y4 receptors are less well conserved.
NPY (show NPY Proteins) and agonists of Y2R and Y5R may be neuroprotective against oxygen-glucose deprivation-induced neuronal cell death in primary cortical cell cultures after delayed treatment. A Y2R agonist not only diminished transient cerebral ischemia-induced neuronal injury, but also improved functional outcome after delayed treatment. Y5 and especially Y2 receptors may be promising targets for neuroprotection against ischemic damage
Npy1r (show NPY1R Proteins)(Y5R-/-) mice show increased anxiety-related behavior but no changes in hypothalamus-pituitary-adrenocortical axis activity or in body weight growth, independently of gender and mouse strain used as foster mothers. Also, Npy1r (show NPY1R Proteins)(Y5R-/-) mice of both genders display increased spatial reference memory in the Morris water maze test.
Study shows pronounced adaptive changes in the mouse hippocampus both with regard to NPY (show NPY Proteins) synthesis and NPY (show NPY Proteins) receptor synthesis and binding, which may contribute to regulating neuronal seizure susceptibility after kainate
The Y5 receptor subtype, previously believed to mediate food intake, plays a critical role in modulation of hippocampal excitatory transmission at the hilar-to-CA3 (show CA3 Proteins) synapse in the mouse
biological redundancies between Y1 and Y5 receptor signaling in the NPY (show NPY Proteins)-mediated control of food intake.
A limited distribution of Y5R expression is found in the hypothalamus; this receptor may be involved primarily in feeding and body weight control via neuropeptide Y's action on proopiomelanocortin (show POMC Proteins)-expressing neurons.
Results indicate that the NPY Y5 receptor Y5R is involved in the regulation and development of diet-induced obesity and suggest utility for Y5R antagonists in the treatment of obesity.
Npy5r antagonist-treated mice showed an up-regulation of uncoupling protein mRNA in brown adipose tissue (BAT (show BAAT Proteins)) and white adipose tissue (WAT), suggesting that both BAT (show BAAT Proteins) and WAT contribute to energy expenditure.
Show that spironolactone Y5 receptor antagonist has potent antiobesity effects in obese mice.
Feeding behavior and gene expression of appetite-related neuropeptides in mice lacking for neuropeptide Y (show NPY Proteins) Y5 receptor subclass.
Lower mRNA levels of neuropeptide Y (show NPY Proteins) receptor 1 (NPY1R (show NPY1R Proteins)) and NPY5R but not NPY (show NPY Proteins) or NPY2R (show NPY2R Proteins) in the central nucleus of the amygdala predicted elevated anxious temperament.
The objectives of this study were to identify single nucleotide polymorphisms in the bovine NPY5R gene.
Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders (By similarity).
, Y5 receptor
, neuropeptide Y receptor type 5
, Neuropeptide Y5 receptor
, G-protein coupled receptor
, neuropeptide Y receptor Y5
, NPY receptor 5
, neuropeptide Y receptor type 5-like
, NPY Y5
, neuropeptide Y5 receptor