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Three Single-nucleotide polymorphisms (on chromosomes 3 and 11) were associated with vasomotor menopause symptoms in the African American group. However, 14 Single-nucleotide polymorphisms, all located on chromosome 4 in the tachykinin receptor 3 (TACR3) locus, had similar effect sizes across studies/participants' ancestry. Genetic variation in TACR3 may contribute to the risk of vasomotor menopause symptoms.
observations of interspecies variation in the neurokinin 3 receptor brain localization with more extensive distribution in guinea pig than in primate brain; in the human brain, specific binding to the neurokinin 3 receptor was highest in the amygdala and in the hypothalamus and very low in other regions examined
High NK-3R expression is associated with Oral Squamous Cell Carcinoma.
Neuropeptide derivatives to regulate the reproductive axis: Kisspeptin receptor (KISS1R (show KISS1R Proteins)) ligands and neurokinin-3 receptor (NK3R) ligands.
results suggest that peripheral sensory nerve-derived TAC3 (show TAC3 Proteins) may affect gingival oral squamous cell carcinoma cells through TACR3 in the bone matrix
mutations in TAC (show IL2RA Proteins) and TACR3 are not a common cause for ICPP.
None of the 4 single polymorphisms studied in TACR3 are linked directly to puberty onset time, but A63P in TAC3 (show TAC3 Proteins) is statistically associated with precocious puberty.
Elevated CRP (show CRP Proteins) is likely a pathogenic factor contributing to preeclampsia by binding to phosphocholinated neurokinin B and preferentially activating NK3R.
data indicate that GPR54 (show KISS1R Proteins) and TACR3 gene mutations are not a frequent cause of ICPP. The identified A/G synonymous SNP (dbSNP ID: rs10407968) located in exon 1 of the gene is not likely to have a pathogenic role in exon splicing
Studies indicate the molecular mechanisms by which NK3R mutations cause GnRH deficiency.
Data suggest that neurokinin 3 receptor (NK3R) might be a potential target for the anti-angiogenesis therapy.
Data suggest that activation of neurokinin 3 and kappa-opioid receptors (NK3R and KOR (show OPRK1 Proteins)) excites and inhibits kisspeptin, neurokinin B (NKB), and dynorphin (KNDy neurons).
NKB (show TAC3 Proteins)-NK3R signaling plays a role in pubertal maturation; its alterations may contribute to pubertal disorders linked to metabolic stress and negative energy balance.
although capable of fertility, Tacr3-deficient mice have central reproductive defects
neurokinin 3 receptor activation in the median preoptic nucleus modulates body temperature
Tachykinin NK3 receptor genes are expressed in uterine cells, oocytes, ovaries and embryos from mice, and may play a role in female reproductive function.
The co-expression of NK-3R and NMDA/AMPA (show GRIA3 Proteins) receptor subunits in the nigral neurons has provided a structural basis for functional modulation of neuronal glutamate (show GRIN1 Proteins) receptors by neurokinin-3.
In neurokinin 1 receptor knockout retinas no major changes were detected: neurokinin 3 receptor mRNA levels as well as substance P (show TAC1 Proteins) and neurokinin 3 receptor immunostainings were similar to wild types.
these results support a role for the NK(3) receptor in performance of operant tasks and in spatial learning but not in working memory
Together, these results support a role for the NK3 receptor in reactivity to dopaminergic stimuli, but the lack of robust changes indicates that the sensitivity to dopamine may be activity-dependent or benign in nature.
Evidence for tachykinin NK3 receptors-triggered peptide YY release from isolated guinea-pig distal colon
[MePhe]-NKB and senktide caused bronchoconstriction in guinea pig through activation of the tachykinin NK-receptors but the tachykinin NK- and/or NK-receptors are also involved in the response.
This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B.
tachykinin receptor 3
, neuromedin-K receptor-like
, NK-3 receptor
, neurokinin B receptor
, neurokinin beta receptor
, neuromedin-K receptor
, Nk3 receptor
, neurokinin 3 receptor
, neuromedin K receptor
, Neuromedin K receptor (Neurokinin B/Tachikin 3)
, tachikin receptor 3
, neurokinin receptor subtype NK3
, neurokinin-3 receptor
, tachykinin neurokinin-3 receptor